Low vitamin K status is a potential risk factor for COVID-19 infected patients: a systematic review and meta-analysis
ObjectiveTo provide further data support for the treatment of COVID-19 by conducting a comprehensive analysis of reports on dephosphorylated-uncarboxylated Matrix Gla Protein (dp-ucMGP), which detects the functional vitamin K status post COVID-19 infection, using meta-analysis.MethodsThis study cond...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1476622/full |
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| author | Wei Liu Xin Liu Shiwei Kang Yadong Yuan |
| author_facet | Wei Liu Xin Liu Shiwei Kang Yadong Yuan |
| author_sort | Wei Liu |
| collection | DOAJ |
| description | ObjectiveTo provide further data support for the treatment of COVID-19 by conducting a comprehensive analysis of reports on dephosphorylated-uncarboxylated Matrix Gla Protein (dp-ucMGP), which detects the functional vitamin K status post COVID-19 infection, using meta-analysis.MethodsThis study conducted a comprehensive review and analysis of relevant research on dp-ucMGP detection in patients infected with COVID-19 through meta-analysis. The article collection period ranged from January 2024 to April 2024.ResultsA total of 6 articles were included in this study. Baseline data analysis showed that the age of patients in the COVID-19 infected group was greater than that of the non-infected control group (p = 0.030); similarly, the age of patients in the severe infection group was also greater than that of the mild infection group (p = 0.003). In the analysis of underlying diseases, statistical differences were found between the Severe group and Mild group in the presence of CVD (p = 0.010). A total of 5 studies conducted dp-ucMGP detection in both the COVID-19 infected group and the control group. The results showed that the expression of dp-ucMGP was higher in the infected group than in the control group (p < 0.001). Subgroup analysis revealed that the expression of dp-ucMGP in the severe infection group was also higher than that in the mild infection group (p < 0.001).ConclusionCOVID-19 infected patients exhibit Low Vitamin K Status, which correlates positively with the severity of infection. Supplementation of vitamin K during COVID-19 infection may potentially mitigate the progression toward severe infection, necessitating further support from clinical data. |
| format | Article |
| id | doaj-art-a3ca79e0873a40199e3585c0e4aba758 |
| institution | OA Journals |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-a3ca79e0873a40199e3585c0e4aba7582025-08-20T02:08:14ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-04-011210.3389/fnut.2025.14766221476622Low vitamin K status is a potential risk factor for COVID-19 infected patients: a systematic review and meta-analysisWei Liu0Xin Liu1Shiwei Kang2Yadong Yuan3First Department of Pulmonary and Critical Care Medicine, Hebei Chest Hospital, Shijiazhuang, ChinaSecond Department of Pulmonary and Critical Care Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, ChinaSecond Department of Pulmonary and Critical Care Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, ChinaSecond Department of Pulmonary and Critical Care Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, ChinaObjectiveTo provide further data support for the treatment of COVID-19 by conducting a comprehensive analysis of reports on dephosphorylated-uncarboxylated Matrix Gla Protein (dp-ucMGP), which detects the functional vitamin K status post COVID-19 infection, using meta-analysis.MethodsThis study conducted a comprehensive review and analysis of relevant research on dp-ucMGP detection in patients infected with COVID-19 through meta-analysis. The article collection period ranged from January 2024 to April 2024.ResultsA total of 6 articles were included in this study. Baseline data analysis showed that the age of patients in the COVID-19 infected group was greater than that of the non-infected control group (p = 0.030); similarly, the age of patients in the severe infection group was also greater than that of the mild infection group (p = 0.003). In the analysis of underlying diseases, statistical differences were found between the Severe group and Mild group in the presence of CVD (p = 0.010). A total of 5 studies conducted dp-ucMGP detection in both the COVID-19 infected group and the control group. The results showed that the expression of dp-ucMGP was higher in the infected group than in the control group (p < 0.001). Subgroup analysis revealed that the expression of dp-ucMGP in the severe infection group was also higher than that in the mild infection group (p < 0.001).ConclusionCOVID-19 infected patients exhibit Low Vitamin K Status, which correlates positively with the severity of infection. Supplementation of vitamin K during COVID-19 infection may potentially mitigate the progression toward severe infection, necessitating further support from clinical data.https://www.frontiersin.org/articles/10.3389/fnut.2025.1476622/fullCOVID-19low vitamin K statusdephosphorylated-uncarboxylated matrix Gla proteinmeta-analysisdp-ucMGP |
| spellingShingle | Wei Liu Xin Liu Shiwei Kang Yadong Yuan Low vitamin K status is a potential risk factor for COVID-19 infected patients: a systematic review and meta-analysis Frontiers in Nutrition COVID-19 low vitamin K status dephosphorylated-uncarboxylated matrix Gla protein meta-analysis dp-ucMGP |
| title | Low vitamin K status is a potential risk factor for COVID-19 infected patients: a systematic review and meta-analysis |
| title_full | Low vitamin K status is a potential risk factor for COVID-19 infected patients: a systematic review and meta-analysis |
| title_fullStr | Low vitamin K status is a potential risk factor for COVID-19 infected patients: a systematic review and meta-analysis |
| title_full_unstemmed | Low vitamin K status is a potential risk factor for COVID-19 infected patients: a systematic review and meta-analysis |
| title_short | Low vitamin K status is a potential risk factor for COVID-19 infected patients: a systematic review and meta-analysis |
| title_sort | low vitamin k status is a potential risk factor for covid 19 infected patients a systematic review and meta analysis |
| topic | COVID-19 low vitamin K status dephosphorylated-uncarboxylated matrix Gla protein meta-analysis dp-ucMGP |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1476622/full |
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