Application of Transcriptome Analysis for the Exploration of the Mechanism of Methionine Promoting the Synthesis of Cephalosporin C in <i>Acremonium chrysogenum</i> by Employing a Chemically Defined Medium

Application of Transcriptome Analysis for the Exploration of the Mechanism of Methionine Promoting the Synthesis of Cephalosporin C in <i>Acremonium chrysogenum</i> by Employing a Chemically Defined Medium

To better analyze the biosynthesis mechanism of cephalosporin C (CPC) in <i>Acremonium chrysogenum</i>, single-factor omission experiments and Plackett–Burman (PB) experimental design were employed to identify key components in the chemically defined medium. Response surface methodology...

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Bibliographic Details
Main Authors: Yifan Li, Zhen Chen, Wei Hong, Tao Feng, Xiwei Tian, Ju Chu
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Fermentation
Subjects:
Cephalosporin C
chemically defined medium
methionine
transcriptomics
Online Access:https://www.mdpi.com/2311-5637/11/6/325
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