Cannabis, Collaterals, and Coronary Occlusion
A 51-year-old gentleman, who regularly smoked cannabis, presented with chest pain and diaphoresis. He was haemodynamically stable. ECG showed ST depression, inferiorly, and 1 mm ST elevation in lead aVR. Emergent coronary angiography showed thrombotic occlusion of the left main coronary artery (LMCA...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Case Reports in Cardiology |
| Online Access: | http://dx.doi.org/10.1155/2011/469850 |
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| _version_ | 1850171054575583232 |
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| author | Kalpa De Silva Divaka Perera |
| author_facet | Kalpa De Silva Divaka Perera |
| author_sort | Kalpa De Silva |
| collection | DOAJ |
| description | A 51-year-old gentleman, who regularly smoked cannabis, presented with chest pain and diaphoresis. He was haemodynamically stable. ECG showed ST depression, inferiorly, and 1 mm ST elevation in lead aVR. Emergent coronary angiography showed thrombotic occlusion of the left main coronary artery (LMCA), the dominant RCA provided Rentrop grade II collaterals to the LAD. The LMCA was successfully reopened by deployment of a bare-metal stent. Animal heart models suggest that endogenous cannibinoids may cause ischaemic preconditioning. This case suggests that the severity of ischaemia, and hence ECG changes and haemodynamic consequences following an acute occlusion of the LMCA, can be ameliorated by coronary collateralisation and possibly by preconditioning of the myocardium. |
| format | Article |
| id | doaj-art-a3c8066c5b8a42a198a3da6a09b57989 |
| institution | OA Journals |
| issn | 2090-6404 2090-6412 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Cardiology |
| spelling | doaj-art-a3c8066c5b8a42a198a3da6a09b579892025-08-20T02:20:21ZengWileyCase Reports in Cardiology2090-64042090-64122011-01-01201110.1155/2011/469850469850Cannabis, Collaterals, and Coronary OcclusionKalpa De Silva0Divaka Perera1Cardiovascular Division, Rayne Institute, St Thomas' Hospital, London SE1 7EH, UKCardiovascular Division, Rayne Institute, St Thomas' Hospital, London SE1 7EH, UKA 51-year-old gentleman, who regularly smoked cannabis, presented with chest pain and diaphoresis. He was haemodynamically stable. ECG showed ST depression, inferiorly, and 1 mm ST elevation in lead aVR. Emergent coronary angiography showed thrombotic occlusion of the left main coronary artery (LMCA), the dominant RCA provided Rentrop grade II collaterals to the LAD. The LMCA was successfully reopened by deployment of a bare-metal stent. Animal heart models suggest that endogenous cannibinoids may cause ischaemic preconditioning. This case suggests that the severity of ischaemia, and hence ECG changes and haemodynamic consequences following an acute occlusion of the LMCA, can be ameliorated by coronary collateralisation and possibly by preconditioning of the myocardium.http://dx.doi.org/10.1155/2011/469850 |
| spellingShingle | Kalpa De Silva Divaka Perera Cannabis, Collaterals, and Coronary Occlusion Case Reports in Cardiology |
| title | Cannabis, Collaterals, and Coronary Occlusion |
| title_full | Cannabis, Collaterals, and Coronary Occlusion |
| title_fullStr | Cannabis, Collaterals, and Coronary Occlusion |
| title_full_unstemmed | Cannabis, Collaterals, and Coronary Occlusion |
| title_short | Cannabis, Collaterals, and Coronary Occlusion |
| title_sort | cannabis collaterals and coronary occlusion |
| url | http://dx.doi.org/10.1155/2011/469850 |
| work_keys_str_mv | AT kalpadesilva cannabiscollateralsandcoronaryocclusion AT divakaperera cannabiscollateralsandcoronaryocclusion |