Small HSPs at the crossroad between protein aggregation, autophagy and unconventional secretion: clinical implications and potential therapeutic opportunities in the context of neurodegenerative diseases

Small HSPs at the crossroad between protein aggregation, autophagy and unconventional secretion: clinical implications and potential therapeutic opportunities in the context of neurodegenerative diseases

Neurodegenerative diseases (NDs) such as Alzheimer’s, Parkinson’s and Huntington’s diseases as well as ataxias and fronto-temporal disorders are all characterized by the progressive accumulation of protein aggregates (amyloids) into inclusions bodies. In addition, recent experimental evidence is cha...

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Bibliographic Details
Main Authors: Raffaella Bonavita, Fulvia Vitale, Luigi Vittorio Verdicchio, Sarah V. Williams, Maria Gabriella Caporaso, Angeleen Fleming, Maurizio Renna
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
small heat shock proteins
protein misfolding
protein oligomerization and aggregation
autophagy
unconventional protein secretion
extracellular vesicles and exosomes
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1538377/full
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