Baclofen-Induced Encephalopathy in End Stage Renal Disease
Baclofen is a highly used centrally acting GABA agonist that continues to be an effective therapy for spasticity and chronic hiccups. The renally dependent excretion determines the circulating concentrations and guides effective dosing to decrease adverse reactions. Caution should be considered in a...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2015/203936 |
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| _version_ | 1850171053978943488 |
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| author | Andrew Meillier Cara Heller Shyam Patel |
| author_facet | Andrew Meillier Cara Heller Shyam Patel |
| author_sort | Andrew Meillier |
| collection | DOAJ |
| description | Baclofen is a highly used centrally acting GABA agonist that continues to be an effective therapy for spasticity and chronic hiccups. The renally dependent excretion determines the circulating concentrations and guides effective dosing to decrease adverse reactions. Caution should be considered in administering baclofen to patients with decreased renal function. We present a patient with end stage renal disease on hemodialysis with recent baclofen ingestion who presented with toxic encephalopathy that was resolved with additional dialysis sessions. |
| format | Article |
| id | doaj-art-a3c3f71dc4cf4431a278dd01cb4569ea |
| institution | OA Journals |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-a3c3f71dc4cf4431a278dd01cb4569ea2025-08-20T02:20:21ZengWileyCase Reports in Medicine1687-96271687-96352015-01-01201510.1155/2015/203936203936Baclofen-Induced Encephalopathy in End Stage Renal DiseaseAndrew Meillier0Cara Heller1Shyam Patel2Department of Medicine, Temple University Hospital, Philadelphia, PA, USADepartment of Medicine, Temple University Hospital, Philadelphia, PA, USADepartment of Medicine, Temple University Hospital, Philadelphia, PA, USABaclofen is a highly used centrally acting GABA agonist that continues to be an effective therapy for spasticity and chronic hiccups. The renally dependent excretion determines the circulating concentrations and guides effective dosing to decrease adverse reactions. Caution should be considered in administering baclofen to patients with decreased renal function. We present a patient with end stage renal disease on hemodialysis with recent baclofen ingestion who presented with toxic encephalopathy that was resolved with additional dialysis sessions.http://dx.doi.org/10.1155/2015/203936 |
| spellingShingle | Andrew Meillier Cara Heller Shyam Patel Baclofen-Induced Encephalopathy in End Stage Renal Disease Case Reports in Medicine |
| title | Baclofen-Induced Encephalopathy in End Stage Renal Disease |
| title_full | Baclofen-Induced Encephalopathy in End Stage Renal Disease |
| title_fullStr | Baclofen-Induced Encephalopathy in End Stage Renal Disease |
| title_full_unstemmed | Baclofen-Induced Encephalopathy in End Stage Renal Disease |
| title_short | Baclofen-Induced Encephalopathy in End Stage Renal Disease |
| title_sort | baclofen induced encephalopathy in end stage renal disease |
| url | http://dx.doi.org/10.1155/2015/203936 |
| work_keys_str_mv | AT andrewmeillier baclofeninducedencephalopathyinendstagerenaldisease AT caraheller baclofeninducedencephalopathyinendstagerenaldisease AT shyampatel baclofeninducedencephalopathyinendstagerenaldisease |