STAT5 and TET2 Cooperate to Regulate FOXP3-TSDR Demethylation in CD4+ T Cells of Patients with Colorectal Cancer
The tumor-infiltrating Tregs are linked to colorectal cancer progression and outcome. FOXP3 is regarded as a critical developmental and functional factor for Tregs. FOXP3-TSDR demethylation is required for stable expression of FOXP3 and maintenance of Treg function. In our study, we found specific D...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/6985031 |
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| author | Hulin Ma Weishi Gao Xiaoxia Sun Weixing Wang |
| author_facet | Hulin Ma Weishi Gao Xiaoxia Sun Weixing Wang |
| author_sort | Hulin Ma |
| collection | DOAJ |
| description | The tumor-infiltrating Tregs are linked to colorectal cancer progression and outcome. FOXP3 is regarded as a critical developmental and functional factor for Tregs. FOXP3-TSDR demethylation is required for stable expression of FOXP3 and maintenance of Treg function. In our study, we found specific DNA hypomethylation of FOXP3-TSDR in CD4+ T cells from colon tumor tissues as compared with normal colonic tissues. Moreover, we also found that the expression of STAT5 and TET2 was increased in CD4+ T cells from colon tumor tissues, and the superfluous STAT5 and TET2 binding to FOXP3-TSDR resulted in DNA hypomethylation. In conclusion, we have demonstrated that excessive amounts of STAT5 may bind more TET2 to the FOXP3-TSDR and upregulate FOXP3 expression via DNA demethylation. Our study improved the mechanism of FOXP3-TSDR hypomethylation in tumor-infiltrating CD4+ T cells of CRC patients. |
| format | Article |
| id | doaj-art-a3bfacdfe2fb4d98adad09195bb1e308 |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-a3bfacdfe2fb4d98adad09195bb1e3082025-08-20T02:20:20ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/69850316985031STAT5 and TET2 Cooperate to Regulate FOXP3-TSDR Demethylation in CD4+ T Cells of Patients with Colorectal CancerHulin Ma0Weishi Gao1Xiaoxia Sun2Weixing Wang3Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaDepartment of Abdominal Tumor Surgery, Inner Mongolia People’s Hospital, Inner Mongolia Autonomous Region, ChinaDepartment of Abdominal Tumor Surgery, Inner Mongolia People’s Hospital, Inner Mongolia Autonomous Region, ChinaDepartment of General Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaThe tumor-infiltrating Tregs are linked to colorectal cancer progression and outcome. FOXP3 is regarded as a critical developmental and functional factor for Tregs. FOXP3-TSDR demethylation is required for stable expression of FOXP3 and maintenance of Treg function. In our study, we found specific DNA hypomethylation of FOXP3-TSDR in CD4+ T cells from colon tumor tissues as compared with normal colonic tissues. Moreover, we also found that the expression of STAT5 and TET2 was increased in CD4+ T cells from colon tumor tissues, and the superfluous STAT5 and TET2 binding to FOXP3-TSDR resulted in DNA hypomethylation. In conclusion, we have demonstrated that excessive amounts of STAT5 may bind more TET2 to the FOXP3-TSDR and upregulate FOXP3 expression via DNA demethylation. Our study improved the mechanism of FOXP3-TSDR hypomethylation in tumor-infiltrating CD4+ T cells of CRC patients.http://dx.doi.org/10.1155/2018/6985031 |
| spellingShingle | Hulin Ma Weishi Gao Xiaoxia Sun Weixing Wang STAT5 and TET2 Cooperate to Regulate FOXP3-TSDR Demethylation in CD4+ T Cells of Patients with Colorectal Cancer Journal of Immunology Research |
| title | STAT5 and TET2 Cooperate to Regulate FOXP3-TSDR Demethylation in CD4+ T Cells of Patients with Colorectal Cancer |
| title_full | STAT5 and TET2 Cooperate to Regulate FOXP3-TSDR Demethylation in CD4+ T Cells of Patients with Colorectal Cancer |
| title_fullStr | STAT5 and TET2 Cooperate to Regulate FOXP3-TSDR Demethylation in CD4+ T Cells of Patients with Colorectal Cancer |
| title_full_unstemmed | STAT5 and TET2 Cooperate to Regulate FOXP3-TSDR Demethylation in CD4+ T Cells of Patients with Colorectal Cancer |
| title_short | STAT5 and TET2 Cooperate to Regulate FOXP3-TSDR Demethylation in CD4+ T Cells of Patients with Colorectal Cancer |
| title_sort | stat5 and tet2 cooperate to regulate foxp3 tsdr demethylation in cd4 t cells of patients with colorectal cancer |
| url | http://dx.doi.org/10.1155/2018/6985031 |
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