Clinical research progress on the relationship between vitamin D and glucose metabolism disorders

Approximately 10% of the global adult population has diabetes, with accumulating evidence linking suboptimal vitamin D levels to an increased risk of type 2 diabetes and its complications. Current clinical studies suggest that vitamin D supplementation may enhance insulin sensitivity and improve gly...

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Main Authors: Yin CHEN, Zhitian ZHANG, Jiaojiao LIU, Hongmei YAN, Shanshan GUO
Format: Article
Language:English
Published: Shanghai Chinese Clinical Medicine Press Co., Ltd. 2025-06-01
Series:Zhongguo Linchuang Yixue
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Online Access:https://www.c-jcm.com/article/doi/10.12025/j.issn.1008-6358.2025.20241157
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author Yin CHEN
Zhitian ZHANG
Jiaojiao LIU
Hongmei YAN
Shanshan GUO
author_facet Yin CHEN
Zhitian ZHANG
Jiaojiao LIU
Hongmei YAN
Shanshan GUO
author_sort Yin CHEN
collection DOAJ
description Approximately 10% of the global adult population has diabetes, with accumulating evidence linking suboptimal vitamin D levels to an increased risk of type 2 diabetes and its complications. Current clinical studies suggest that vitamin D supplementation may enhance insulin sensitivity and improve glycemic control, prompting significant interest in its potential as a therapeutic intervention. However, further high-quality, large-scale randomized controlled trials are required to validate its efficacy in glucose metabolism regulation and clarify the underlying molecular mechanisms. These investigations will provide critical evidence to inform precision medicine approaches for diabetes prevention and management.
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institution Kabale University
issn 1008-6358
language English
publishDate 2025-06-01
publisher Shanghai Chinese Clinical Medicine Press Co., Ltd.
record_format Article
series Zhongguo Linchuang Yixue
spelling doaj-art-a3bf11a33f9b4667a80fe1832a18cecf2025-08-20T03:29:03ZengShanghai Chinese Clinical Medicine Press Co., Ltd.Zhongguo Linchuang Yixue1008-63582025-06-0132351251810.12025/j.issn.1008-6358.2025.2024115720241157Clinical research progress on the relationship between vitamin D and glucose metabolism disordersYin CHEN0Zhitian ZHANG1Jiaojiao LIU2Hongmei YAN3Shanshan GUO4Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaDepartment of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaDepartment of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaDepartment of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaSchool of Sports and Health, Shanghai University of Sport, Shanghai 200438, ChinaApproximately 10% of the global adult population has diabetes, with accumulating evidence linking suboptimal vitamin D levels to an increased risk of type 2 diabetes and its complications. Current clinical studies suggest that vitamin D supplementation may enhance insulin sensitivity and improve glycemic control, prompting significant interest in its potential as a therapeutic intervention. However, further high-quality, large-scale randomized controlled trials are required to validate its efficacy in glucose metabolism regulation and clarify the underlying molecular mechanisms. These investigations will provide critical evidence to inform precision medicine approaches for diabetes prevention and management.https://www.c-jcm.com/article/doi/10.12025/j.issn.1008-6358.2025.20241157glucose metabolism disordervitamin dclinical research
spellingShingle Yin CHEN
Zhitian ZHANG
Jiaojiao LIU
Hongmei YAN
Shanshan GUO
Clinical research progress on the relationship between vitamin D and glucose metabolism disorders
Zhongguo Linchuang Yixue
glucose metabolism disorder
vitamin d
clinical research
title Clinical research progress on the relationship between vitamin D and glucose metabolism disorders
title_full Clinical research progress on the relationship between vitamin D and glucose metabolism disorders
title_fullStr Clinical research progress on the relationship between vitamin D and glucose metabolism disorders
title_full_unstemmed Clinical research progress on the relationship between vitamin D and glucose metabolism disorders
title_short Clinical research progress on the relationship between vitamin D and glucose metabolism disorders
title_sort clinical research progress on the relationship between vitamin d and glucose metabolism disorders
topic glucose metabolism disorder
vitamin d
clinical research
url https://www.c-jcm.com/article/doi/10.12025/j.issn.1008-6358.2025.20241157
work_keys_str_mv AT yinchen clinicalresearchprogressontherelationshipbetweenvitamindandglucosemetabolismdisorders
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AT jiaojiaoliu clinicalresearchprogressontherelationshipbetweenvitamindandglucosemetabolismdisorders
AT hongmeiyan clinicalresearchprogressontherelationshipbetweenvitamindandglucosemetabolismdisorders
AT shanshanguo clinicalresearchprogressontherelationshipbetweenvitamindandglucosemetabolismdisorders