Cancer type and gene signatures associated with breakthrough infections following COVID-19 mRNA vaccination
Abstract We used epidemiological data from 21195 patients with cancer and 180407 matched controls, including in-depth analyses in 216 cancer patients, to discover clinical and molecular determinants that predispose cancer patients to breakthrough infections. Patients with B cell malignancies, with d...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-05-01
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| Series: | npj Vaccines |
| Online Access: | https://doi.org/10.1038/s41541-025-01141-w |
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| author | Youjia Zhong Jiaqi Li Ainsley Ryan Yan Bin Lee Janice Yu Jin Tan Carina Jing Xuan Tay Clara WT Koh Ethan Yong Tzi Seow Wee Chee Yap Shi Yin Wong Chun En Yau Chen Ee Low Kelvin Bryan Tan Barnaby Edward Young Yan Su Arun George Devasia Perumal Dharuman Alexander Lezhava Rahul Pandey Panneer Selvi Govindaraju Sidney Yee Ruifen Weng Candy Khoo Shaun Shi Yan Tan Matilda Lee Joline Lim Esther Chan Carol LF Ho Louis Yi Ann Chai Chee Wah Tan Soo Chin Lee Kuan Rong Chan Raghav Sundar |
| author_facet | Youjia Zhong Jiaqi Li Ainsley Ryan Yan Bin Lee Janice Yu Jin Tan Carina Jing Xuan Tay Clara WT Koh Ethan Yong Tzi Seow Wee Chee Yap Shi Yin Wong Chun En Yau Chen Ee Low Kelvin Bryan Tan Barnaby Edward Young Yan Su Arun George Devasia Perumal Dharuman Alexander Lezhava Rahul Pandey Panneer Selvi Govindaraju Sidney Yee Ruifen Weng Candy Khoo Shaun Shi Yan Tan Matilda Lee Joline Lim Esther Chan Carol LF Ho Louis Yi Ann Chai Chee Wah Tan Soo Chin Lee Kuan Rong Chan Raghav Sundar |
| author_sort | Youjia Zhong |
| collection | DOAJ |
| description | Abstract We used epidemiological data from 21195 patients with cancer and 180407 matched controls, including in-depth analyses in 216 cancer patients, to discover clinical and molecular determinants that predispose cancer patients to breakthrough infections. Patients with B cell malignancies, with differential expression of CD24, CDK14 and PLEKHG1, were most susceptible to breakthrough infections, suggesting that these patients may require more booster immunisations to ameliorate cellular responses and immune protection against COVID-19. |
| format | Article |
| id | doaj-art-a3be82a706914b47a4369f6d444f4ef8 |
| institution | OA Journals |
| issn | 2059-0105 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Vaccines |
| spelling | doaj-art-a3be82a706914b47a4369f6d444f4ef82025-08-20T02:15:01ZengNature Portfolionpj Vaccines2059-01052025-05-011011610.1038/s41541-025-01141-wCancer type and gene signatures associated with breakthrough infections following COVID-19 mRNA vaccinationYoujia Zhong0Jiaqi Li1Ainsley Ryan Yan Bin Lee2Janice Yu Jin Tan3Carina Jing Xuan Tay4Clara WT Koh5Ethan Yong Tzi Seow6Wee Chee Yap7Shi Yin Wong8Chun En Yau9Chen Ee Low10Kelvin Bryan Tan11Barnaby Edward Young12Yan Su13Arun George Devasia14Perumal Dharuman15Alexander Lezhava16Rahul Pandey17Panneer Selvi Govindaraju18Sidney Yee19Ruifen Weng20Candy Khoo21Shaun Shi Yan Tan22Matilda Lee23Joline Lim24Esther Chan25Carol LF Ho26Louis Yi Ann Chai27Chee Wah Tan28Soo Chin Lee29Kuan Rong Chan30Raghav Sundar31Department of Paediatrics, Yong Loo Lin School of Medicine, National University of SingaporeDepartment of Medicine, Stanford UniversityYong Loo Lin School of Medicine, National University of SingaporeMinistry of HealthDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of SingaporeProgramme in Emerging Infectious Diseases, Duke-NUS Medical SchoolProgramme in Emerging Infectious Diseases, Duke-NUS Medical SchoolInfectious Diseases Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, NUSYong Loo Lin School of Medicine, National University of SingaporeYong Loo Lin School of Medicine, National University of SingaporeYong Loo Lin School of Medicine, National University of SingaporeMinistry of HealthNational Centre for Infectious DiseasesGenome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)Diagnostics Development (DxD) Hub, Agency of Science, Technology and Research (A*STAR)Diagnostics Development (DxD) Hub, Agency of Science, Technology and Research (A*STAR)Diagnostics Development (DxD) Hub, Agency of Science, Technology and Research (A*STAR)Diagnostics Development (DxD) Hub, Agency of Science, Technology and Research (A*STAR)Department of Laboratory Medicine, National University HospitalDepartment of Laboratory Medicine, National University HospitalDepartment of Haematology-Oncology, National University Cancer InstituteDepartment of Haematology-Oncology, National University Cancer InstituteDepartment of Haematology-Oncology, National University Cancer InstituteDepartment of Haematology-Oncology, National University Cancer InstituteDivision of Infectious Diseases, Department of Medicine, National University HospitalInfectious Diseases Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, NUSYong Loo Lin School of Medicine, National University of SingaporeProgramme in Emerging Infectious Diseases, Duke-NUS Medical SchoolYong Loo Lin School of Medicine, National University of SingaporeAbstract We used epidemiological data from 21195 patients with cancer and 180407 matched controls, including in-depth analyses in 216 cancer patients, to discover clinical and molecular determinants that predispose cancer patients to breakthrough infections. Patients with B cell malignancies, with differential expression of CD24, CDK14 and PLEKHG1, were most susceptible to breakthrough infections, suggesting that these patients may require more booster immunisations to ameliorate cellular responses and immune protection against COVID-19.https://doi.org/10.1038/s41541-025-01141-w |
| spellingShingle | Youjia Zhong Jiaqi Li Ainsley Ryan Yan Bin Lee Janice Yu Jin Tan Carina Jing Xuan Tay Clara WT Koh Ethan Yong Tzi Seow Wee Chee Yap Shi Yin Wong Chun En Yau Chen Ee Low Kelvin Bryan Tan Barnaby Edward Young Yan Su Arun George Devasia Perumal Dharuman Alexander Lezhava Rahul Pandey Panneer Selvi Govindaraju Sidney Yee Ruifen Weng Candy Khoo Shaun Shi Yan Tan Matilda Lee Joline Lim Esther Chan Carol LF Ho Louis Yi Ann Chai Chee Wah Tan Soo Chin Lee Kuan Rong Chan Raghav Sundar Cancer type and gene signatures associated with breakthrough infections following COVID-19 mRNA vaccination npj Vaccines |
| title | Cancer type and gene signatures associated with breakthrough infections following COVID-19 mRNA vaccination |
| title_full | Cancer type and gene signatures associated with breakthrough infections following COVID-19 mRNA vaccination |
| title_fullStr | Cancer type and gene signatures associated with breakthrough infections following COVID-19 mRNA vaccination |
| title_full_unstemmed | Cancer type and gene signatures associated with breakthrough infections following COVID-19 mRNA vaccination |
| title_short | Cancer type and gene signatures associated with breakthrough infections following COVID-19 mRNA vaccination |
| title_sort | cancer type and gene signatures associated with breakthrough infections following covid 19 mrna vaccination |
| url | https://doi.org/10.1038/s41541-025-01141-w |
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