Gut microbiota: a crucial player in the combat against tuberculosis
The mammalian gastrointestinal tract quickly becomes densely populated with foreign microorganisms shortly after birth, thereby establishing a lifelong presence of a microbial community. These commensal gut microbiota serve various functions, such as providing nutrients, processing ingested compound...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-10-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1442095/full |
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| author | Jie Lin Jie Lin Dongli Chen Dongli Chen Yongen Yan Yongen Yan Jiang Pi Jiang Pi Jiang Pi Junfa Xu Junfa Xu Lingming Chen Lingming Chen Lingming Chen Biying Zheng Biying Zheng |
| author_facet | Jie Lin Jie Lin Dongli Chen Dongli Chen Yongen Yan Yongen Yan Jiang Pi Jiang Pi Jiang Pi Junfa Xu Junfa Xu Lingming Chen Lingming Chen Lingming Chen Biying Zheng Biying Zheng |
| author_sort | Jie Lin |
| collection | DOAJ |
| description | The mammalian gastrointestinal tract quickly becomes densely populated with foreign microorganisms shortly after birth, thereby establishing a lifelong presence of a microbial community. These commensal gut microbiota serve various functions, such as providing nutrients, processing ingested compounds, maintaining gut homeostasis, and shaping the intestinal structure in the host. Dysbiosis, which is characterized by an imbalance in the microbial community, is closely linked to numerous human ailments and has recently emerged as a key factor in health prognosis. Tuberculosis (TB), a highly contagious and potentially fatal disease, presents a pressing need for improved methods of prevention, diagnosis, and treatment strategies. Thus, we aim to explore the latest developments on how the host’s immune defenses, inflammatory responses, metabolic pathways, and nutritional status collectively impact the host’s susceptibility to or resilience against Mycobacterium tuberculosis infection. The review addresses how the fluctuations in the gut microbiota not only affect the equilibrium of these physiological processes but also indirectly influence the host’s capacity to resist M. tuberculosis. This work highlights the central role of the gut microbiota in the host–microbe interactions and provides novel insights for the advancement of preventative and therapeutic approaches against tuberculosis. |
| format | Article |
| id | doaj-art-a3bad17858c74dcea9eff26f4e40fa21 |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-a3bad17858c74dcea9eff26f4e40fa212025-08-20T02:08:42ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-10-011510.3389/fimmu.2024.14420951442095Gut microbiota: a crucial player in the combat against tuberculosisJie Lin0Jie Lin1Dongli Chen2Dongli Chen3Yongen Yan4Yongen Yan5Jiang Pi6Jiang Pi7Jiang Pi8Junfa Xu9Junfa Xu10Lingming Chen11Lingming Chen12Lingming Chen13Biying Zheng14Biying Zheng15Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, Guangdong, ChinaInstitute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, Guangdong, ChinaGuangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, Guangdong, ChinaInstitute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, Guangdong, ChinaGuangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, Guangdong, ChinaInstitute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, Guangdong, ChinaGuangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, Guangdong, ChinaInstitute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, Guangdong, ChinaThe Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, Guangdong, ChinaGuangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, Guangdong, ChinaInstitute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, Guangdong, ChinaGuangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, Guangdong, ChinaInstitute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, Guangdong, ChinaThe Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, Guangdong, ChinaGuangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, Guangdong, ChinaInstitute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, Guangdong, ChinaThe mammalian gastrointestinal tract quickly becomes densely populated with foreign microorganisms shortly after birth, thereby establishing a lifelong presence of a microbial community. These commensal gut microbiota serve various functions, such as providing nutrients, processing ingested compounds, maintaining gut homeostasis, and shaping the intestinal structure in the host. Dysbiosis, which is characterized by an imbalance in the microbial community, is closely linked to numerous human ailments and has recently emerged as a key factor in health prognosis. Tuberculosis (TB), a highly contagious and potentially fatal disease, presents a pressing need for improved methods of prevention, diagnosis, and treatment strategies. Thus, we aim to explore the latest developments on how the host’s immune defenses, inflammatory responses, metabolic pathways, and nutritional status collectively impact the host’s susceptibility to or resilience against Mycobacterium tuberculosis infection. The review addresses how the fluctuations in the gut microbiota not only affect the equilibrium of these physiological processes but also indirectly influence the host’s capacity to resist M. tuberculosis. This work highlights the central role of the gut microbiota in the host–microbe interactions and provides novel insights for the advancement of preventative and therapeutic approaches against tuberculosis.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1442095/fulldysbiosistuberculosisgut microbiotamicroecologygut-lung axis |
| spellingShingle | Jie Lin Jie Lin Dongli Chen Dongli Chen Yongen Yan Yongen Yan Jiang Pi Jiang Pi Jiang Pi Junfa Xu Junfa Xu Lingming Chen Lingming Chen Lingming Chen Biying Zheng Biying Zheng Gut microbiota: a crucial player in the combat against tuberculosis Frontiers in Immunology dysbiosis tuberculosis gut microbiota microecology gut-lung axis |
| title | Gut microbiota: a crucial player in the combat against tuberculosis |
| title_full | Gut microbiota: a crucial player in the combat against tuberculosis |
| title_fullStr | Gut microbiota: a crucial player in the combat against tuberculosis |
| title_full_unstemmed | Gut microbiota: a crucial player in the combat against tuberculosis |
| title_short | Gut microbiota: a crucial player in the combat against tuberculosis |
| title_sort | gut microbiota a crucial player in the combat against tuberculosis |
| topic | dysbiosis tuberculosis gut microbiota microecology gut-lung axis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1442095/full |
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