Occurrence of BRCA1 and BRCA2 mutation in pancreatic cancer patients

BRCA1 and BRCA2 may contribute in pancreatic cancer (PC) risk, however the selection criteria for BRCA1 testing are poorly defined. The analysis of Russian founder mutation BRCA1 5382insC in 150 PC patients identified 2 carriers. BRCA2 full-length sequencing of 8 DNA samples revealed 1 mutated allel...

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Main Authors: A. A. Kashintsev, G. A. Yanus, N. Yu. Kokhanenko, V. M. Moiseenko, M. D. Hanevich, L. D. Roman, A. G. Ievleva, A. P. Sokolenko, E. N. Suspitsin, A. I. Budovskiy, A. V. Togo, N. M. Volkov, R. V. Fadeev, M. S. Dinikin, A. K. Ivanova, K. G. Shostko, E. N. Imyanitov
Format: Article
Language:Russian
Published: Russian Academy of Sciences, Tomsk National Research Medical Center 2016-02-01
Series:Сибирский онкологический журнал
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Online Access:https://www.siboncoj.ru/jour/article/view/237
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author A. A. Kashintsev
G. A. Yanus
N. Yu. Kokhanenko
V. M. Moiseenko
M. D. Hanevich
L. D. Roman
A. G. Ievleva
A. P. Sokolenko
E. N. Suspitsin
A. I. Budovskiy
A. V. Togo
N. M. Volkov
R. V. Fadeev
M. S. Dinikin
A. K. Ivanova
K. G. Shostko
E. N. Imyanitov
author_facet A. A. Kashintsev
G. A. Yanus
N. Yu. Kokhanenko
V. M. Moiseenko
M. D. Hanevich
L. D. Roman
A. G. Ievleva
A. P. Sokolenko
E. N. Suspitsin
A. I. Budovskiy
A. V. Togo
N. M. Volkov
R. V. Fadeev
M. S. Dinikin
A. K. Ivanova
K. G. Shostko
E. N. Imyanitov
author_sort A. A. Kashintsev
collection DOAJ
description BRCA1 and BRCA2 may contribute in pancreatic cancer (PC) risk, however the selection criteria for BRCA1 testing are poorly defined. The analysis of Russian founder mutation BRCA1 5382insC in 150 PC patients identified 2 carriers. BRCA2 full-length sequencing of 8 DNA samples revealed 1 mutated allele (BRCA2 5197_5198delTC). All 3 carriers of BRCA1/2 mutations reported personal or familial history of BRCA-related cancers. Thus, BRCA1/2 testing is particularly
format Article
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institution Kabale University
issn 1814-4861
2312-3168
language Russian
publishDate 2016-02-01
publisher Russian Academy of Sciences, Tomsk National Research Medical Center
record_format Article
series Сибирский онкологический журнал
spelling doaj-art-a3b518da81a44326890291ca8d4694ff2025-08-20T03:56:24ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682016-02-01053944237Occurrence of BRCA1 and BRCA2 mutation in pancreatic cancer patientsA. A. Kashintsev0G. A. Yanus1N. Yu. Kokhanenko2V. M. Moiseenko3M. D. Hanevich4L. D. Roman5A. G. Ievleva6A. P. Sokolenko7E. N. Suspitsin8A. I. Budovskiy9A. V. Togo10N. M. Volkov11R. V. Fadeev12M. S. Dinikin13A. K. Ivanova14K. G. Shostko15E. N. Imyanitov16St.-Petersburg Pediatric Medical UniversitySt.-Petersburg Pediatric Medical University, N.N. Petrov Institute of Oncology, St.-PetersburgSt.-Petersburg Pediatric Medical UniversityCity Oncological Center, St.-Petersburg, S.M. Beresin Clinical Center, St.-PetersburgCity Oncological Hospital, St.-PetersburgLeningrad Regional Oncological Hospital, St.-PetersburgSt.-Petersburg Pediatric Medical University, N.N. Petrov Institute of Oncology, St.-PetersburgSt.-Petersburg Pediatric Medical University, N.N. Petrov Institute of Oncology, St.-PetersburgSt.-Petersburg Pediatric Medical University, N.N. Petrov Institute of Oncology, St.-PetersburgN.N. Petrov Institute of Oncology, St.-PetersburgSt.-Petersburg Pediatric Medical University, N.N. Petrov Institute of Oncology, St.-PetersburgN.N. Petrov Institute of Oncology, St.-Petersburg, S.M. Beresin Clinical Center, St.-PetersburgCity Oncological Hospital, St.-PetersburgCity Oncological Hospital, St.-PetersburgCity Oncological Hospital, St.-PetersburgLeningrad Regional Oncological Hospital, St.-PetersburgSt.-Petersburg Pediatric Medical University, N.N. Petrov Institute of Oncology, St.-Petersburg, I.I. Mechnikov North-West Medical University, St.-PetersburgBRCA1 and BRCA2 may contribute in pancreatic cancer (PC) risk, however the selection criteria for BRCA1 testing are poorly defined. The analysis of Russian founder mutation BRCA1 5382insC in 150 PC patients identified 2 carriers. BRCA2 full-length sequencing of 8 DNA samples revealed 1 mutated allele (BRCA2 5197_5198delTC). All 3 carriers of BRCA1/2 mutations reported personal or familial history of BRCA-related cancers. Thus, BRCA1/2 testing is particularlyhttps://www.siboncoj.ru/jour/article/view/237рак поджелудочной железыbrca1brca2наследственный рак молочной железы и яичников
spellingShingle A. A. Kashintsev
G. A. Yanus
N. Yu. Kokhanenko
V. M. Moiseenko
M. D. Hanevich
L. D. Roman
A. G. Ievleva
A. P. Sokolenko
E. N. Suspitsin
A. I. Budovskiy
A. V. Togo
N. M. Volkov
R. V. Fadeev
M. S. Dinikin
A. K. Ivanova
K. G. Shostko
E. N. Imyanitov
Occurrence of BRCA1 and BRCA2 mutation in pancreatic cancer patients
Сибирский онкологический журнал
рак поджелудочной железы
brca1
brca2
наследственный рак молочной железы и яичников
title Occurrence of BRCA1 and BRCA2 mutation in pancreatic cancer patients
title_full Occurrence of BRCA1 and BRCA2 mutation in pancreatic cancer patients
title_fullStr Occurrence of BRCA1 and BRCA2 mutation in pancreatic cancer patients
title_full_unstemmed Occurrence of BRCA1 and BRCA2 mutation in pancreatic cancer patients
title_short Occurrence of BRCA1 and BRCA2 mutation in pancreatic cancer patients
title_sort occurrence of brca1 and brca2 mutation in pancreatic cancer patients
topic рак поджелудочной железы
brca1
brca2
наследственный рак молочной железы и яичников
url https://www.siboncoj.ru/jour/article/view/237
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