Impact of hypertension on changes in peripapillary retinal nerve fiber layer thickness in type 2 diabetes patients
Abstract To determine longitudinal changes in the peripapillary retinal nerve fiber layer (pRNFL) thickness in type 2 diabetes mellitus (T2DM) patients with hypertension (HTN). Participants were divided into three groups: normal controls (Group 1), patients with T2DM (Group 2), and patients with bot...
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Nature Portfolio
2025-01-01
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| author | Jae-Yun Sung Tae-Seen Kang Ka-Hyun Lee Min-Woo Lee |
| author_facet | Jae-Yun Sung Tae-Seen Kang Ka-Hyun Lee Min-Woo Lee |
| author_sort | Jae-Yun Sung |
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| description | Abstract To determine longitudinal changes in the peripapillary retinal nerve fiber layer (pRNFL) thickness in type 2 diabetes mellitus (T2DM) patients with hypertension (HTN). Participants were divided into three groups: normal controls (Group 1), patients with T2DM (Group 2), and patients with both T2DM and HTN (Group 3). Following the initial examination, patients underwent three additional examinations at 1-year intervals. Linear mixed models were used to identify significant changes in pRNFL thickness over time. The baseline mean pRNFL thickness was 95.4 ± 7.9, 93.6 ± 7.8, and 90.7 ± 10.1 μm in Group 1, Group 2, and Group 3, respectively, (P = 0.046). The reduction rate for mean pRNFL thickness was − 0.15 μm/y in Group 1, – 0.54 μm/y in Group 2, and − 1.06 μm/y in Group 3, respectively (P = 0.026). In Group 2, T2DM duration (estimate = − 0.63, P = 0.002) was a significant factor associated with changes in pRNFL thickness in multivariate analysis. In Group 3, HTN duration (estimate = − 0.59, P = 0.036) and HbA1c levels (estimate = − 4.44, P = 0.019) were significantly associated with pRNFL changes. Under ischemic conditions caused by HTN, pRNFL damage due to diabetic retinal neurodegeneration is considered to be more severe. In such patients, the duration of ischemic damage caused by HTN appears to have a significant impact on pRNFL damage, and stricter blood glucose level control could help reduce pRNFL damage. |
| format | Article |
| id | doaj-art-a3b0ba3cf29349c3917267a26e825516 |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-a3b0ba3cf29349c3917267a26e8255162025-01-05T12:18:19ZengNature PortfolioScientific Reports2045-23222025-01-011511710.1038/s41598-025-85295-6Impact of hypertension on changes in peripapillary retinal nerve fiber layer thickness in type 2 diabetes patientsJae-Yun Sung0Tae-Seen Kang1Ka-Hyun Lee2Min-Woo Lee3Department of Ophthalmology, Chungnam National University Sejong HospitalDepartment of Ophthalmology, Chungnam National University Sejong HospitalDepartment of Ophthalmology, Konyang University College of MedicineDepartment of Ophthalmology, Konyang University College of MedicineAbstract To determine longitudinal changes in the peripapillary retinal nerve fiber layer (pRNFL) thickness in type 2 diabetes mellitus (T2DM) patients with hypertension (HTN). Participants were divided into three groups: normal controls (Group 1), patients with T2DM (Group 2), and patients with both T2DM and HTN (Group 3). Following the initial examination, patients underwent three additional examinations at 1-year intervals. Linear mixed models were used to identify significant changes in pRNFL thickness over time. The baseline mean pRNFL thickness was 95.4 ± 7.9, 93.6 ± 7.8, and 90.7 ± 10.1 μm in Group 1, Group 2, and Group 3, respectively, (P = 0.046). The reduction rate for mean pRNFL thickness was − 0.15 μm/y in Group 1, – 0.54 μm/y in Group 2, and − 1.06 μm/y in Group 3, respectively (P = 0.026). In Group 2, T2DM duration (estimate = − 0.63, P = 0.002) was a significant factor associated with changes in pRNFL thickness in multivariate analysis. In Group 3, HTN duration (estimate = − 0.59, P = 0.036) and HbA1c levels (estimate = − 4.44, P = 0.019) were significantly associated with pRNFL changes. Under ischemic conditions caused by HTN, pRNFL damage due to diabetic retinal neurodegeneration is considered to be more severe. In such patients, the duration of ischemic damage caused by HTN appears to have a significant impact on pRNFL damage, and stricter blood glucose level control could help reduce pRNFL damage.https://doi.org/10.1038/s41598-025-85295-6Type 2 diabetesHypertensionRetinal nerve fiber layer |
| spellingShingle | Jae-Yun Sung Tae-Seen Kang Ka-Hyun Lee Min-Woo Lee Impact of hypertension on changes in peripapillary retinal nerve fiber layer thickness in type 2 diabetes patients Scientific Reports Type 2 diabetes Hypertension Retinal nerve fiber layer |
| title | Impact of hypertension on changes in peripapillary retinal nerve fiber layer thickness in type 2 diabetes patients |
| title_full | Impact of hypertension on changes in peripapillary retinal nerve fiber layer thickness in type 2 diabetes patients |
| title_fullStr | Impact of hypertension on changes in peripapillary retinal nerve fiber layer thickness in type 2 diabetes patients |
| title_full_unstemmed | Impact of hypertension on changes in peripapillary retinal nerve fiber layer thickness in type 2 diabetes patients |
| title_short | Impact of hypertension on changes in peripapillary retinal nerve fiber layer thickness in type 2 diabetes patients |
| title_sort | impact of hypertension on changes in peripapillary retinal nerve fiber layer thickness in type 2 diabetes patients |
| topic | Type 2 diabetes Hypertension Retinal nerve fiber layer |
| url | https://doi.org/10.1038/s41598-025-85295-6 |
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