Targeting METTL3 as a checkpoint to enhance T cells for tumour immunotherapy

Targeting METTL3 as a checkpoint to enhance T cells for tumour immunotherapy

ABSTRACT Background Immunotherapy has emerged as a crucial treatment modality for solid tumours, yet tumours often evade immune surveillance. There is an imperative to uncover novel immune regulators that can boost tumour immunogenicity and increase the efficacy of immune checkpoint blockade (ICB) t...

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Main Authors: Kaixin Wu, Sa Li, Guangliang Hong, Hongzhi Dong, Tongke Tang, He Liu, Lingmei Jin, Siyuan Lin, Jingyun Ji, Mingli Hu, Shuntian Chen, Haoyuan Wu, Guanzheng Luo, Xiangqian Kong, Jiekai Chen, Jiangping He, Hongling Wu
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Clinical and Translational Medicine
Subjects:
B16 melanoma
immunotherapy
METTL3
N6‐methyladenosine (m6A)
T‐cell function
YTHDF2
Online Access:https://doi.org/10.1002/ctm2.70089
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