Zinc transporter ZIP13 and diseases
Zinc is an important regulator of various biological processes such as protein synthesis, cell proliferation, migration and autophagy. The zinc transporter ZIP13 (SLC39A13) is a homodimeric metal transporter functioning in transport of zinc, iron, and calcium plasma in body. ZIP13 is involved in dis...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2024-12-01
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| Series: | Jichu yixue yu linchuang |
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| Online Access: | https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2024-44-12-1712.pdf |
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| _version_ | 1850061002085761024 |
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| author | LI Huanhuan, MA Jing, DENG Peipei, LIU Xuan, WANG Shusong |
| author_facet | LI Huanhuan, MA Jing, DENG Peipei, LIU Xuan, WANG Shusong |
| author_sort | LI Huanhuan, MA Jing, DENG Peipei, LIU Xuan, WANG Shusong |
| collection | DOAJ |
| description | Zinc is an important regulator of various biological processes such as protein synthesis, cell proliferation, migration and autophagy. The zinc transporter ZIP13 (SLC39A13) is a homodimeric metal transporter functioning in transport of zinc, iron, and calcium plasma in body. ZIP13 is involved in disease by regulating zinc homeostasis, such as the key role of ZIP13 in connective tissue development because it is involved in the BMP/TGF-β signaling pathway. ZIP13 promotes the metastasis of human ovarian cancer cells by activating the Src/FAK signaling pathway and ZIP13 inhibits the biogenesis and energy expenditure of beige adipocytes by regulating C/EBP-β expression. |
| format | Article |
| id | doaj-art-a3aa274ae3bb4fecb75c9bfc1e9ae157 |
| institution | DOAJ |
| issn | 1001-6325 |
| language | zho |
| publishDate | 2024-12-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj-art-a3aa274ae3bb4fecb75c9bfc1e9ae1572025-08-20T02:50:23ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252024-12-0144121712171610.16352/j.issn.1001-6325.2024.12.1712Zinc transporter ZIP13 and diseasesLI Huanhuan, MA Jing, DENG Peipei, LIU Xuan, WANG Shusong0Hebei Key Laboratory of Reproductive Medicine, Hebei Reproductive Health Hospital, Shijiazhuang 050071, ChinaZinc is an important regulator of various biological processes such as protein synthesis, cell proliferation, migration and autophagy. The zinc transporter ZIP13 (SLC39A13) is a homodimeric metal transporter functioning in transport of zinc, iron, and calcium plasma in body. ZIP13 is involved in disease by regulating zinc homeostasis, such as the key role of ZIP13 in connective tissue development because it is involved in the BMP/TGF-β signaling pathway. ZIP13 promotes the metastasis of human ovarian cancer cells by activating the Src/FAK signaling pathway and ZIP13 inhibits the biogenesis and energy expenditure of beige adipocytes by regulating C/EBP-β expression.https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2024-44-12-1712.pdfzinc transporter|zip13|ehlers-danlos syndrome|ion transport |
| spellingShingle | LI Huanhuan, MA Jing, DENG Peipei, LIU Xuan, WANG Shusong Zinc transporter ZIP13 and diseases Jichu yixue yu linchuang zinc transporter|zip13|ehlers-danlos syndrome|ion transport |
| title | Zinc transporter ZIP13 and diseases |
| title_full | Zinc transporter ZIP13 and diseases |
| title_fullStr | Zinc transporter ZIP13 and diseases |
| title_full_unstemmed | Zinc transporter ZIP13 and diseases |
| title_short | Zinc transporter ZIP13 and diseases |
| title_sort | zinc transporter zip13 and diseases |
| topic | zinc transporter|zip13|ehlers-danlos syndrome|ion transport |
| url | https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2024-44-12-1712.pdf |
| work_keys_str_mv | AT lihuanhuanmajingdengpeipeiliuxuanwangshusong zinctransporterzip13anddiseases |