Interplay between gut microbiota and acute kidney injury: a review of their mutual influence and causation
It is unclear, therefore, exactly how gut microbes and renal processes communicate. Recent developments in the field of microbiome research present chances to enhance our comprehension and management of acute kidney injury (AKI). This review highlights important ideas and suggests more research whil...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2522976 |
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| author | Niroj Mali Saroj Mali Ling Zhang Ping Fu |
| author_facet | Niroj Mali Saroj Mali Ling Zhang Ping Fu |
| author_sort | Niroj Mali |
| collection | DOAJ |
| description | It is unclear, therefore, exactly how gut microbes and renal processes communicate. Recent developments in the field of microbiome research present chances to enhance our comprehension and management of acute kidney injury (AKI). This review highlights important ideas and suggests more research while giving a general summary of the microbiome’s influence on kidney function and AKI. AKI is a complex condition that develops through a variety of pathways. Recent experimental research has highlighted the important role that the gut microbiota plays in the course of AKI. Our understanding of human biology has been completely transformed by the current increase in gut microbiota research. Amazing progress in DNA sequencing analysis, especially in the areas of metagenomics and metatranscriptomics, has greatly increased our ability to measure and track complex microbial populations. As such, we are now in a better position to look at how these communities affect human health and illness. As a result, the relationships between renal physiology and pathophysiology and the gut microbiota are now better understood. Both experimental AKI and chronic renal illness have been linked to changes in the intestinal microbiome. This succinct review attempts to examine our present knowledge of the immune-modulatory effects of the gut microbiota, how kidney disorders are influenced by it, and the possible reciprocal interaction between kidney diseases and the microbiota. Subsequent investigations ought to concentrate on delving deeper into the function of the gut microbiota in renal disorders and finding possible therapeutic strategies for adjusting it. |
| format | Article |
| id | doaj-art-a3a82756f5b04d808e2d18aeef63706a |
| institution | DOAJ |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-a3a82756f5b04d808e2d18aeef63706a2025-08-20T02:42:03ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492025-12-0147110.1080/0886022X.2025.2522976Interplay between gut microbiota and acute kidney injury: a review of their mutual influence and causationNiroj Mali0Saroj Mali1Ling Zhang2Ping Fu3Department of Nephrology and Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, ChinaSchool of Computer Science and Engineering, Central South University, Changsha, ChinaDepartment of Nephrology and Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Nephrology and Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, ChinaIt is unclear, therefore, exactly how gut microbes and renal processes communicate. Recent developments in the field of microbiome research present chances to enhance our comprehension and management of acute kidney injury (AKI). This review highlights important ideas and suggests more research while giving a general summary of the microbiome’s influence on kidney function and AKI. AKI is a complex condition that develops through a variety of pathways. Recent experimental research has highlighted the important role that the gut microbiota plays in the course of AKI. Our understanding of human biology has been completely transformed by the current increase in gut microbiota research. Amazing progress in DNA sequencing analysis, especially in the areas of metagenomics and metatranscriptomics, has greatly increased our ability to measure and track complex microbial populations. As such, we are now in a better position to look at how these communities affect human health and illness. As a result, the relationships between renal physiology and pathophysiology and the gut microbiota are now better understood. Both experimental AKI and chronic renal illness have been linked to changes in the intestinal microbiome. This succinct review attempts to examine our present knowledge of the immune-modulatory effects of the gut microbiota, how kidney disorders are influenced by it, and the possible reciprocal interaction between kidney diseases and the microbiota. Subsequent investigations ought to concentrate on delving deeper into the function of the gut microbiota in renal disorders and finding possible therapeutic strategies for adjusting it.https://www.tandfonline.com/doi/10.1080/0886022X.2025.2522976Intestinal microbiotaacute kidney injuryshort chain fatty acidmicrobiomegut microbiotametabolome |
| spellingShingle | Niroj Mali Saroj Mali Ling Zhang Ping Fu Interplay between gut microbiota and acute kidney injury: a review of their mutual influence and causation Renal Failure Intestinal microbiota acute kidney injury short chain fatty acid microbiome gut microbiota metabolome |
| title | Interplay between gut microbiota and acute kidney injury: a review of their mutual influence and causation |
| title_full | Interplay between gut microbiota and acute kidney injury: a review of their mutual influence and causation |
| title_fullStr | Interplay between gut microbiota and acute kidney injury: a review of their mutual influence and causation |
| title_full_unstemmed | Interplay between gut microbiota and acute kidney injury: a review of their mutual influence and causation |
| title_short | Interplay between gut microbiota and acute kidney injury: a review of their mutual influence and causation |
| title_sort | interplay between gut microbiota and acute kidney injury a review of their mutual influence and causation |
| topic | Intestinal microbiota acute kidney injury short chain fatty acid microbiome gut microbiota metabolome |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2522976 |
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