Serum parathyroid hormone trajectory during the first year of hemodialysis: a roadmap to severe hyperparathyroidism
Abstract Background: Data on parathyroid hormone (PTH) levels at hemodialysis (HD) initiation and during the first year of therapy are still scarce. We hypothesized that high baseline PTH levels contribute to more severe hyperparathyroidism during this period. Methods: Incident HD patients (n = 1,...
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Sociedade Brasileira de Nefrologia
2025-03-01
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| Series: | Brazilian Journal of Nephrology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002025000200307&lng=en&tlng=en |
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| author | Eduardo J. Duque Maria Eugenia F. Canziani Ana Beatriz L. Barra Maria A. Dalboni Jorge P. Strogoff-de-Matos Rosilene M. Elias Rosa M. A. Moysés |
| author_facet | Eduardo J. Duque Maria Eugenia F. Canziani Ana Beatriz L. Barra Maria A. Dalboni Jorge P. Strogoff-de-Matos Rosilene M. Elias Rosa M. A. Moysés |
| author_sort | Eduardo J. Duque |
| collection | DOAJ |
| description | Abstract Background: Data on parathyroid hormone (PTH) levels at hemodialysis (HD) initiation and during the first year of therapy are still scarce. We hypothesized that high baseline PTH levels contribute to more severe hyperparathyroidism during this period. Methods: Incident HD patients (n = 1,973) were divided into 3 groups according to PTH values (<150, 150–600, and > 600 pg/mL). Results: PTH levels at baseline and at 1 year were 273 (133–508) and 255 (128–471) pg/mL, respectively (p = 0.291). PTH < 150, 150–600 and >600 pg/mL were found in 28.1, 53.5 and 18.4%, respectively, at baseline and 30.7, 52.5 and 16.8% after 1 year (p = 0.015). Younger age, absence of diabetes, high baseline alkaline phosphatase and PTH were independent risk factors for PTH > 600 pg/mL after 1 year of HD. Conclusion: High PTH at the beginning and after 1 year of HD indicate poor conservative management before and during dialysis, and put patients at risk of requiring parathyroidectomy later. |
| format | Article |
| id | doaj-art-a3a3ec6e2fb14e5da112daede781a6ee |
| institution | OA Journals |
| issn | 2175-8239 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Sociedade Brasileira de Nefrologia |
| record_format | Article |
| series | Brazilian Journal of Nephrology |
| spelling | doaj-art-a3a3ec6e2fb14e5da112daede781a6ee2025-08-20T02:24:25ZengSociedade Brasileira de NefrologiaBrazilian Journal of Nephrology2175-82392025-03-0147210.1590/2175-8239-jbn-2024-0182enSerum parathyroid hormone trajectory during the first year of hemodialysis: a roadmap to severe hyperparathyroidismEduardo J. Duquehttps://orcid.org/0000-0002-5099-9727Maria Eugenia F. Canzianihttps://orcid.org/0000-0002-9645-5303Ana Beatriz L. Barrahttps://orcid.org/0000-0003-4453-0698Maria A. Dalbonihttps://orcid.org/0000-0002-9282-7181Jorge P. Strogoff-de-Matoshttps://orcid.org/0000-0003-3518-9803Rosilene M. Eliashttps://orcid.org/0000-0003-2212-041XRosa M. A. Moyséshttps://orcid.org/0000-0002-7902-2127Abstract Background: Data on parathyroid hormone (PTH) levels at hemodialysis (HD) initiation and during the first year of therapy are still scarce. We hypothesized that high baseline PTH levels contribute to more severe hyperparathyroidism during this period. Methods: Incident HD patients (n = 1,973) were divided into 3 groups according to PTH values (<150, 150–600, and > 600 pg/mL). Results: PTH levels at baseline and at 1 year were 273 (133–508) and 255 (128–471) pg/mL, respectively (p = 0.291). PTH < 150, 150–600 and >600 pg/mL were found in 28.1, 53.5 and 18.4%, respectively, at baseline and 30.7, 52.5 and 16.8% after 1 year (p = 0.015). Younger age, absence of diabetes, high baseline alkaline phosphatase and PTH were independent risk factors for PTH > 600 pg/mL after 1 year of HD. Conclusion: High PTH at the beginning and after 1 year of HD indicate poor conservative management before and during dialysis, and put patients at risk of requiring parathyroidectomy later.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002025000200307&lng=en&tlng=enParathyroid HormoneDialysisHyperparathyroidismSecondaryChronic Kidney Disease-MineralBone Disorder |
| spellingShingle | Eduardo J. Duque Maria Eugenia F. Canziani Ana Beatriz L. Barra Maria A. Dalboni Jorge P. Strogoff-de-Matos Rosilene M. Elias Rosa M. A. Moysés Serum parathyroid hormone trajectory during the first year of hemodialysis: a roadmap to severe hyperparathyroidism Brazilian Journal of Nephrology Parathyroid Hormone Dialysis Hyperparathyroidism Secondary Chronic Kidney Disease-Mineral Bone Disorder |
| title | Serum parathyroid hormone trajectory during the first year of hemodialysis: a roadmap to severe hyperparathyroidism |
| title_full | Serum parathyroid hormone trajectory during the first year of hemodialysis: a roadmap to severe hyperparathyroidism |
| title_fullStr | Serum parathyroid hormone trajectory during the first year of hemodialysis: a roadmap to severe hyperparathyroidism |
| title_full_unstemmed | Serum parathyroid hormone trajectory during the first year of hemodialysis: a roadmap to severe hyperparathyroidism |
| title_short | Serum parathyroid hormone trajectory during the first year of hemodialysis: a roadmap to severe hyperparathyroidism |
| title_sort | serum parathyroid hormone trajectory during the first year of hemodialysis a roadmap to severe hyperparathyroidism |
| topic | Parathyroid Hormone Dialysis Hyperparathyroidism Secondary Chronic Kidney Disease-Mineral Bone Disorder |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002025000200307&lng=en&tlng=en |
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