Systemic Inflammation and Gastrointestinal Complications in HIV Patients: A Cross-Sectional Study on the Role of Type II Diabetes
(1) Background: This study aimed to assess the association between inflammatory biomarkers and gastrointestinal side effects in HIV-positive patients on antiretroviral therapy (ART), with a specific focus on the impact of type II diabetes. (2) Methods: A total of 320 participants were divided into t...
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MDPI AG
2025-01-01
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| Online Access: | https://www.mdpi.com/2076-0817/14/1/34 |
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| author | Madalina-Ianca Suba Bogdan Hogea Ahmed Abu-Awwad Daniela Gurgus Roxana Folescu Madalina-Otilia Timircan Simona-Alina Abu-Awwad |
| author_facet | Madalina-Ianca Suba Bogdan Hogea Ahmed Abu-Awwad Daniela Gurgus Roxana Folescu Madalina-Otilia Timircan Simona-Alina Abu-Awwad |
| author_sort | Madalina-Ianca Suba |
| collection | DOAJ |
| description | (1) Background: This study aimed to assess the association between inflammatory biomarkers and gastrointestinal side effects in HIV-positive patients on antiretroviral therapy (ART), with a specific focus on the impact of type II diabetes. (2) Methods: A total of 320 participants were divided into three groups: 120 HIV-positive without diabetes, 80 HIV-positive with type II diabetes, and 120 controls. Biomarkers such as CRP, IL-6, and TNF-α, along with gastrointestinal symptoms, were measured before and six months after ART. (3) Results: HIV-positive patients with type II diabetes exhibited significantly elevated levels of inflammatory markers and experienced more frequent gastrointestinal side effects, particularly nausea and diarrhea. (4) Conclusions: Type II diabetes significantly worsens inflammation and gastrointestinal side effects in HIV patients on ART, suggesting the need for tailored treatment approaches. |
| format | Article |
| id | doaj-art-a3a26363029443feb7b3f1a844ad9705 |
| institution | Kabale University |
| issn | 2076-0817 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj-art-a3a26363029443feb7b3f1a844ad97052025-01-24T13:44:40ZengMDPI AGPathogens2076-08172025-01-011413410.3390/pathogens14010034Systemic Inflammation and Gastrointestinal Complications in HIV Patients: A Cross-Sectional Study on the Role of Type II DiabetesMadalina-Ianca Suba0Bogdan Hogea1Ahmed Abu-Awwad2Daniela Gurgus3Roxana Folescu4Madalina-Otilia Timircan5Simona-Alina Abu-Awwad6Doctoral School, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, RomaniaDepartment XV—Discipline of Orthopedics-Traumatology, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDepartment XV—Discipline of Orthopedics-Traumatology, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDepartment of Balneology, Medical Recovery and Rheumatology, Family Discipline, Center for Preventive Medicine, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDepartment of Balneology, Medical Recovery and Rheumatology, Family Discipline, Center for Preventive Medicine, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaIst Clinic of Obstetrics and Gynecology, “Pius Brinzeu” County Clinical Emergency Hospital, 300723 Timisoara, RomaniaIst Clinic of Obstetrics and Gynecology, “Pius Brinzeu” County Clinical Emergency Hospital, 300723 Timisoara, Romania(1) Background: This study aimed to assess the association between inflammatory biomarkers and gastrointestinal side effects in HIV-positive patients on antiretroviral therapy (ART), with a specific focus on the impact of type II diabetes. (2) Methods: A total of 320 participants were divided into three groups: 120 HIV-positive without diabetes, 80 HIV-positive with type II diabetes, and 120 controls. Biomarkers such as CRP, IL-6, and TNF-α, along with gastrointestinal symptoms, were measured before and six months after ART. (3) Results: HIV-positive patients with type II diabetes exhibited significantly elevated levels of inflammatory markers and experienced more frequent gastrointestinal side effects, particularly nausea and diarrhea. (4) Conclusions: Type II diabetes significantly worsens inflammation and gastrointestinal side effects in HIV patients on ART, suggesting the need for tailored treatment approaches.https://www.mdpi.com/2076-0817/14/1/34HIVantiretroviral therapytype II diabetesinflammatory biomarkersgastrointestinal side effectschronic inflammation |
| spellingShingle | Madalina-Ianca Suba Bogdan Hogea Ahmed Abu-Awwad Daniela Gurgus Roxana Folescu Madalina-Otilia Timircan Simona-Alina Abu-Awwad Systemic Inflammation and Gastrointestinal Complications in HIV Patients: A Cross-Sectional Study on the Role of Type II Diabetes Pathogens HIV antiretroviral therapy type II diabetes inflammatory biomarkers gastrointestinal side effects chronic inflammation |
| title | Systemic Inflammation and Gastrointestinal Complications in HIV Patients: A Cross-Sectional Study on the Role of Type II Diabetes |
| title_full | Systemic Inflammation and Gastrointestinal Complications in HIV Patients: A Cross-Sectional Study on the Role of Type II Diabetes |
| title_fullStr | Systemic Inflammation and Gastrointestinal Complications in HIV Patients: A Cross-Sectional Study on the Role of Type II Diabetes |
| title_full_unstemmed | Systemic Inflammation and Gastrointestinal Complications in HIV Patients: A Cross-Sectional Study on the Role of Type II Diabetes |
| title_short | Systemic Inflammation and Gastrointestinal Complications in HIV Patients: A Cross-Sectional Study on the Role of Type II Diabetes |
| title_sort | systemic inflammation and gastrointestinal complications in hiv patients a cross sectional study on the role of type ii diabetes |
| topic | HIV antiretroviral therapy type II diabetes inflammatory biomarkers gastrointestinal side effects chronic inflammation |
| url | https://www.mdpi.com/2076-0817/14/1/34 |
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