Carotid Baroreceptor Stimulation for the Treatment of Resistant Hypertension
Interventional activation of the carotid baroreflex has been an appealing idea for the management of resistant hypertension for several decades, yet its clinical application remained elusive and a goal for the future. It is only recently that the profound understanding of the complex anatomy and pat...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.4061/2011/964394 |
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| author | Vasilios Papademetriou Michael Doumas Charles Faselis Constantinos Tsioufis Stella Douma Eugene Gkaliagkousi Chrysanthos Zamboulis |
| author_facet | Vasilios Papademetriou Michael Doumas Charles Faselis Constantinos Tsioufis Stella Douma Eugene Gkaliagkousi Chrysanthos Zamboulis |
| author_sort | Vasilios Papademetriou |
| collection | DOAJ |
| description | Interventional activation of the carotid baroreflex has been an appealing idea for the management of resistant hypertension for several decades, yet its clinical application remained elusive and a goal for the future. It is only recently that the profound understanding of the complex anatomy and pathophysiology of the circuit, combined with the accumulation of relevant experimental and clinical data both in animals and in humans, has allowed the development of a more effective and well-promising approach. Indeed, current data support a sustained over a transient reduction of blood pressure through the resetting of baroreceptors, and technical deficits have been minimized with a subsequent recession of adverse events. In addition, clinical outcomes from the application of a new implantable device (Rheos) that induces carotid baroreceptor stimulation point towards a safe and effective blood pressure reduction, but longer experience is needed before its integration in the everyday clinical practice. While accumulating evidence indicates that carotid baroreceptor stimulation exerts its benefits beyond blood pressure reduction, further research is necessary to assess the spectrum of beneficial effects and evaluate potential hazards, before the extraction of secure conclusions. |
| format | Article |
| id | doaj-art-a3a22a0e08ac4b8793e1e237a94320da |
| institution | Kabale University |
| issn | 2090-0392 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-a3a22a0e08ac4b8793e1e237a94320da2025-02-03T06:07:13ZengWileyInternational Journal of Hypertension2090-03922011-01-01201110.4061/2011/964394964394Carotid Baroreceptor Stimulation for the Treatment of Resistant HypertensionVasilios Papademetriou0Michael Doumas1Charles Faselis2Constantinos Tsioufis3Stella Douma4Eugene Gkaliagkousi5Chrysanthos Zamboulis6Veterans Affairs Medical Center, Georgetown University, Washington, DC 20422, USAVeterans Affairs Medical Center, George Washington University, Washington, DC 20037, USAVeterans Affairs Medical Center, George Washington University, Washington, DC 20037, USAVeterans Affairs Medical Center, Georgetown University, Washington, DC 20422, USA2nd Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, 54643 Thessaloniki, Greece2nd Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, 54643 Thessaloniki, Greece2nd Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, 54643 Thessaloniki, GreeceInterventional activation of the carotid baroreflex has been an appealing idea for the management of resistant hypertension for several decades, yet its clinical application remained elusive and a goal for the future. It is only recently that the profound understanding of the complex anatomy and pathophysiology of the circuit, combined with the accumulation of relevant experimental and clinical data both in animals and in humans, has allowed the development of a more effective and well-promising approach. Indeed, current data support a sustained over a transient reduction of blood pressure through the resetting of baroreceptors, and technical deficits have been minimized with a subsequent recession of adverse events. In addition, clinical outcomes from the application of a new implantable device (Rheos) that induces carotid baroreceptor stimulation point towards a safe and effective blood pressure reduction, but longer experience is needed before its integration in the everyday clinical practice. While accumulating evidence indicates that carotid baroreceptor stimulation exerts its benefits beyond blood pressure reduction, further research is necessary to assess the spectrum of beneficial effects and evaluate potential hazards, before the extraction of secure conclusions.http://dx.doi.org/10.4061/2011/964394 |
| spellingShingle | Vasilios Papademetriou Michael Doumas Charles Faselis Constantinos Tsioufis Stella Douma Eugene Gkaliagkousi Chrysanthos Zamboulis Carotid Baroreceptor Stimulation for the Treatment of Resistant Hypertension International Journal of Hypertension |
| title | Carotid Baroreceptor Stimulation for the Treatment of Resistant Hypertension |
| title_full | Carotid Baroreceptor Stimulation for the Treatment of Resistant Hypertension |
| title_fullStr | Carotid Baroreceptor Stimulation for the Treatment of Resistant Hypertension |
| title_full_unstemmed | Carotid Baroreceptor Stimulation for the Treatment of Resistant Hypertension |
| title_short | Carotid Baroreceptor Stimulation for the Treatment of Resistant Hypertension |
| title_sort | carotid baroreceptor stimulation for the treatment of resistant hypertension |
| url | http://dx.doi.org/10.4061/2011/964394 |
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