Therapeutic mucosal vaccination of herpes simplex virus type 2 infected guinea pigs with an adenovirus-based vaccine expressing the ribonucleotide reductase 2 and glycoprotein D induces local tissue-resident CD4+ and CD8+ TRM cells associated with protection against recurrent genital herpes

Therapeutic mucosal vaccination of herpes simplex virus type 2 infected guinea pigs with an adenovirus-based vaccine expressing the ribonucleotide reductase 2 and glycoprotein D induces local tissue-resident CD4+ and CD8+ TRM cells associated with protection against recurrent genital herpes

IntroductionThe reactivation of herpes simplex virus 2 (HSV-2) from latency causes viral shedding that develops into recurrent genital lesions. The role of tissue-resident T cells and the nature of viral antigens associated with protection against recurrent genital herpes remain to be fully elucidat...

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Bibliographic Details
Main Authors: Afshana Quadiri, Swayam Prakash, Hawa Vahed, Jimmy Medhat Tadros, Miyo Sun, Kathy K. Hormi-Carver, Swena Jignesh Patel, Lbachir BenMohamed
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
genital herpes
vaginal mucosa
therapeutic
vaccine
CD4 + T cells
CD8 + T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1568258/full
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