Pharmacological inhibition of Septins with Forchlorfenuron attenuates thrombus formation in experimental thrombotic mice models with modulating multiple signaling pathways in platelets

Pharmacological inhibition of Septins with Forchlorfenuron attenuates thrombus formation in experimental thrombotic mice models with modulating multiple signaling pathways in platelets

Introduction: The Septin family of cytoskeletal proteins is abundant in platelets. When these proteins are functionally blocked using the compound forchlorfenuron (FCF), it hampers the normal activation processes of purified human platelets. Objectives: To evaluate the in vivo effects of FCF on phys...

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Bibliographic Details
Main Authors: Zhen Hao, Minghui Yan, Reyisha Tuerhong, Luying Zhang, Zhen Zhang, Habib Alam, Jun Wu, Yuanhua Qin, Feng Zhao, Lei Shi
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Journal of Advanced Research
Subjects:
Septin
Forchlorfenuron
Platelet
Aggregation
Thrombosis
Online Access:http://www.sciencedirect.com/science/article/pii/S209012322400328X
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