Beta-band power modulation in the human amygdala during a Direct Reach arm reaching task
The human amygdala is primarily known for its involvement in processing emotional and fearful responses, but newer evidence has identified a role for this structure in motor processing. Our lab previously utilized an arm-reaching task and observed significant beta-band (13–30 Hz) modulation in the h...
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| Language: | English |
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Elsevier
2025-07-01
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| Series: | Neuroscience Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0168010225000835 |
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| author | Jonathon Cavaleri Shivani Sundaram Roberto Martin Del Campo-Vera Xiecheng Shao Ryan S. Chung Miguel Parra Adith Swarup Selena Zhang Alexandra Kammen Angad Gogia Xenos Mason Ryan McGinn Christi Heck Charles Y. Liu Spencer S. Kellis Brian Lee |
| author_facet | Jonathon Cavaleri Shivani Sundaram Roberto Martin Del Campo-Vera Xiecheng Shao Ryan S. Chung Miguel Parra Adith Swarup Selena Zhang Alexandra Kammen Angad Gogia Xenos Mason Ryan McGinn Christi Heck Charles Y. Liu Spencer S. Kellis Brian Lee |
| author_sort | Jonathon Cavaleri |
| collection | DOAJ |
| description | The human amygdala is primarily known for its involvement in processing emotional and fearful responses, but newer evidence has identified a role for this structure in motor processing. Our lab previously utilized an arm-reaching task and observed significant beta-band (13–30 Hz) modulation in the hippocampus. Given these results, we sought to characterize the role of beta-band modulation in the amygdala during movement execution in participants with stereoelectroencephalography (SEEG) depth electrodes in the amygdala for seizure localization. We show that 9 of 13 participants (69.2 %) showed decreased beta-band power in the amygdala during the Response (movement execution) phase of an arm-reaching task when compared to Fixation (baseline). Secondary analyses show that there are no statistically significant differences in beta-band modulation between ipsilateral and contralateral implanted electrodes, but there is a small difference between male and female participants. The decrease in beta-band power in the amygdala during the Response phase of a Direct Reach task is consistent with our previous findings in the hippocampus. Our study is the first to report beta-band modulation in the amygdala during motor processing and sets the stage for further studies into the involvement of the amygdala in motor control. |
| format | Article |
| id | doaj-art-a39cc5b68fb94d02b7209393b897deeb |
| institution | OA Journals |
| issn | 0168-0102 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neuroscience Research |
| spelling | doaj-art-a39cc5b68fb94d02b7209393b897deeb2025-08-20T02:34:16ZengElsevierNeuroscience Research0168-01022025-07-0121610490610.1016/j.neures.2025.05.001Beta-band power modulation in the human amygdala during a Direct Reach arm reaching taskJonathon Cavaleri0Shivani Sundaram1Roberto Martin Del Campo-Vera2Xiecheng Shao3Ryan S. Chung4Miguel Parra5Adith Swarup6Selena Zhang7Alexandra Kammen8Angad Gogia9Xenos Mason10Ryan McGinn11Christi Heck12Charles Y. Liu13Spencer S. Kellis14Brian Lee15Department of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States; Correspondence to: Department of Neurological Surgery, University of Southern California, 1200 N. State St. Suite 3300, Los Angeles, CA 90033, United States.Department of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United StatesDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United StatesDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States; Department of Biomedical Engineering, Viterbi School of Engineering of USC, University of Southern California, Los Angeles, CA, United StatesDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United StatesDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States; Department of Biomedical Engineering, Viterbi School of Engineering of USC, University of Southern California, Los Angeles, CA, United StatesDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States; Department of Biomedical Engineering, Viterbi School of Engineering of USC, University of Southern California, Los Angeles, CA, United StatesDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States; Department of Biomedical Engineering, Viterbi School of Engineering of USC, University of Southern California, Los Angeles, CA, United StatesDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United StatesDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United StatesDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United StatesDepartment of Neurology, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United StatesDepartment of Neurology, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States; USC Neurorestoration Center, Keck School of Medicine of USC, Los Angeles, CA, United StatesDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States; Department of Biomedical Engineering, Viterbi School of Engineering of USC, University of Southern California, Los Angeles, CA, United States; USC Neurorestoration Center, Keck School of Medicine of USC, Los Angeles, CA, United StatesDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States; Department of Biomedical Engineering, Viterbi School of Engineering of USC, University of Southern California, Los Angeles, CA, United States; USC Neurorestoration Center, Keck School of Medicine of USC, Los Angeles, CA, United StatesDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States; Department of Biomedical Engineering, Viterbi School of Engineering of USC, University of Southern California, Los Angeles, CA, United States; USC Neurorestoration Center, Keck School of Medicine of USC, Los Angeles, CA, United StatesThe human amygdala is primarily known for its involvement in processing emotional and fearful responses, but newer evidence has identified a role for this structure in motor processing. Our lab previously utilized an arm-reaching task and observed significant beta-band (13–30 Hz) modulation in the hippocampus. Given these results, we sought to characterize the role of beta-band modulation in the amygdala during movement execution in participants with stereoelectroencephalography (SEEG) depth electrodes in the amygdala for seizure localization. We show that 9 of 13 participants (69.2 %) showed decreased beta-band power in the amygdala during the Response (movement execution) phase of an arm-reaching task when compared to Fixation (baseline). Secondary analyses show that there are no statistically significant differences in beta-band modulation between ipsilateral and contralateral implanted electrodes, but there is a small difference between male and female participants. The decrease in beta-band power in the amygdala during the Response phase of a Direct Reach task is consistent with our previous findings in the hippocampus. Our study is the first to report beta-band modulation in the amygdala during motor processing and sets the stage for further studies into the involvement of the amygdala in motor control.http://www.sciencedirect.com/science/article/pii/S0168010225000835AmygdalaStereoelectroencephalography (SEEG)Local field potential (LFP)Beta-band powerCenter-out arm reach taskNon-emotional motor processing |
| spellingShingle | Jonathon Cavaleri Shivani Sundaram Roberto Martin Del Campo-Vera Xiecheng Shao Ryan S. Chung Miguel Parra Adith Swarup Selena Zhang Alexandra Kammen Angad Gogia Xenos Mason Ryan McGinn Christi Heck Charles Y. Liu Spencer S. Kellis Brian Lee Beta-band power modulation in the human amygdala during a Direct Reach arm reaching task Neuroscience Research Amygdala Stereoelectroencephalography (SEEG) Local field potential (LFP) Beta-band power Center-out arm reach task Non-emotional motor processing |
| title | Beta-band power modulation in the human amygdala during a Direct Reach arm reaching task |
| title_full | Beta-band power modulation in the human amygdala during a Direct Reach arm reaching task |
| title_fullStr | Beta-band power modulation in the human amygdala during a Direct Reach arm reaching task |
| title_full_unstemmed | Beta-band power modulation in the human amygdala during a Direct Reach arm reaching task |
| title_short | Beta-band power modulation in the human amygdala during a Direct Reach arm reaching task |
| title_sort | beta band power modulation in the human amygdala during a direct reach arm reaching task |
| topic | Amygdala Stereoelectroencephalography (SEEG) Local field potential (LFP) Beta-band power Center-out arm reach task Non-emotional motor processing |
| url | http://www.sciencedirect.com/science/article/pii/S0168010225000835 |
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