Exploring the Interaction of 3-Hydroxy-4-pyridinone Chelators with Liposome Membrane Models: Insights from DSC and EPR Analysis

Exploring the Interaction of 3-Hydroxy-4-pyridinone Chelators with Liposome Membrane Models: Insights from DSC and EPR Analysis

In this study, we synthesized a series of 3-hydroxy-4-pyridinone (3,4-HPO) chelators with varying lipophilicity by modifying the length of their alkyl chains. To investigate their interaction with lipid membranes, we employed differential scanning calorimetry (DSC) and electron paramagnetic resonanc...

Full description

Saved in:

Bibliographic Details
Main Authors:	Luísa M. P. F. Amaral, Tânia Moniz, Maria Rangel
Format:	Article
Language:	English
Published:	MDPI AG 2024-12-01
Series:	Molecules
Subjects:	3-Hydroxy-4-pyridinone differential scanning calo-hydroxy-4-pyridinone derivatives rimetry (DSC) electron paramagnetic resonance (EPR) liposome membrane interaction
Online Access:	https://www.mdpi.com/1420-3049/29/24/5905
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Design, synthesis and molecular docking of novel 4-chloro-2-(4-(4-(sulfonyl)piperazin-1-yl)phenyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one for the evaluation anti-cancer activity
by: Narender Reddy Modugu, et al.
Published: (2025-05-01)

Radiation-Induced Paramagnetic Centers in Meso- and Macroporous Synthetic Opals from EPR and ENDOR Data
by: Alexander Rodionov, et al.
Published: (2024-10-01)

Determination of copper Ions (II) in Aqueous Solutions Using Organic Reagent 3-Hydroxy-4-[(2-hydroxy benzylidene) amino] naphthalene Sulphonic Acid-1 (HHBAN) by Spectrophotometric method
by: Mohammad Maarouf, et al.
Published: (2025-07-01)

Synthesis of new hybrid molecules based on 7-hydroxy-2,2,4-trimethylhydroquinoline derivatives
by: Gribanova, Yana Александровна, et al.
Published: (2025-03-01)

Synthesis, structural study, antimicrobial activity and theoretical treatment of Cr(III), Ni(II), Pt(IV) and Zn(II) complexes with 2-hydroxy-4-Nitro phenyl piperonalidene
by: Baghdad Science Journal
Published: (2010-03-01)

Experimental Investigation of the Hydroxy Gas Generation as a Clean Energy Source for Spark Ignition Engine Operation Using Different Electrolytes
by: Yousef A. Sharif, et al.
Published: (2021-06-01)

Directed synthesis and search of pharmaceutical substances with hypoglycemic activity in the series of 4-aryl-2-hydroxy-4-oxo-2-butenoic acids
by: N. A. Pulina, et al.
Published: (2011-10-01)

DEVELOPMENT OF OPTIMAL PARAMETERS FOR NEW DERIVANTS DETERMINATION OF 4-(GET)ARYL-2-HYDROXY-4-OXO-2-BUTENIC ACIDS IN THIN LAYER OF SORBENT
by: F. V. Sobin, et al.
Published: (2015-09-01)

Design, synthesis, molecular dynamics studies and biological evaluations of 4-hydroxy-5-pyrrolinone-3-carbohydrazides as HIV-1 integrase inhibitors
by: Nafiseh Karimi, et al.
Published: (2024-12-01)

Study of the Anti-inflammatory Activity of 2-hydroxy-4-oxo-4-R-2-butenoates of Heterylammonium, which Have an Effect on the Blood Clotting System
by: F. V. Sobin, et al.
Published: (2023-12-01)

Studi In Silico Senyawa 1,4-Naphthalenedione-2-Ethyl-3-Hydroxy sebagai Antiinflamasi dan Antikanker Payudara
by: Richa Mardianingrum, et al.
Published: (2021-03-01)

Photoluminescence and EPR Studies of ZnS Nanoparticles Co-Doped With Mn and Te
by: P. Sreedhara Reddy, et al.
Published: (2011-01-01)

Simultaneous Determination of Chlorothalonil and 4-Hydroxy-Chlorothalonil in Sulfur-Rich Vegetables by UHPLC-MS/MS with a Synergistic Enzyme Inhibition Strategy
by: Fengen Wang, et al.
Published: (2025-06-01)

Immunomodulatory effects of 4-hydroxynonenal
by: Melina Ioannidis, et al.
Published: (2025-09-01)

Study of Antifungal Activity of Experimental Soft Dosage Form Based on the Hydrazone Derivative of Getarylamide 4-phenyl-2-hydroxy-4-oxo-2-butenoic acid
by: F. V. Sobin, et al.
Published: (2022-12-01)

Integrated metabolomics and transcriptomics reveal the potential of hydroxy-alpha-sanshool in alleviating insulin resistance
by: Yuping Zhu, et al.
Published: (2025-02-01)

Preparation, Spectroscopy, Biological Activities and Thermodynamic Studies of New Complexes of Some Metal Ions with 2-[5-(2-Hydroxy-Phenyl)- 1,3,4-Thiadiazol-2-Ylimino]-Methyl-Naphthalen-1-Ol]
by: Naser Shaalan
Published: (2022-08-01)

Construction of a Library of Fatty Acid Esters of Hydroxy Fatty Acids
by: Olga G. Mountanea, et al.
Published: (2025-01-01)

Infected burn wound healing using Hydroxy-propyl-methyl cellulose gel containing bacteriophages against Pseudomonas aeruginosa and Klebsiella pneumoniae
by: Meysam Adibi, et al.
Published: (2025-02-01)

International society of sports nutrition position stand: β-hydroxy-β-methylbutyrate (HMB)
by: John A. Rathmacher, et al.
Published: (2025-12-01)

The Distinct Biological Effects of 6-Hydroxy-L-Nicotine in Representative Cancer Cell Lines
by: Paula Alexandra Postu, et al.
Published: (2024-11-01)

Gastroprotective effects of 1-Hydroxy-2-phenylbenzimidazole in ethanol-induced gastric ulcers in rats
by: H M Ezgallaey, et al.
Published: (2016-07-01)

Research progress on the synthesis of 4-hydroxy-2,5-dimethyl-3(2H)-furanone by microorganisms
by: SONG Jinpeng, ZHONG Xiufang, LI Xuesi, CAO Zhenhua, PENG Xinhui, FAN Guangsen
Published: (2024-04-01)

An investigation of the assumed efficacy of methionine hydroxy analogue compared to DL-methionine by measuring growth performance, carcass traits, and GHR and IGF-I expression in broilers
by: Engin Yenice, et al.
Published: (2023-12-01)

Effect of Ionic and Nonionic Compounds Structure on the Fluidity of Model Lipid Membranes: Computer Simulation and EPR Experiment
by: Dariusz Man, et al.
Published: (2024-12-01)

Relation between 25-hydroxy vitamin D and diabetic retinopathy in Egyptian patients with type 2 diabetes mellitus
by: Mervat E. Elwakeel, et al.
Published: (2024-01-01)

Effect of Hydroxy Gas Enrichment and Higher Biodiesel Concentration on Diesel Engine Performance
by: Asnawi Asnawi, et al.
Published: (2025-04-01)

Antitumor Assessment of Liposomal Beta-Carotene with Tamoxifen Against Breast Carcinoma Cell Line: An In Vitro Study
by: Marim H. Elsayed, et al.
Published: (2025-03-01)

Performance and Environmental Assessment of Palm Oil–Coffee Husk Biodiesel Blends in a Dual-Fuel Diesel Engine Operating with Hydroxy
by: Jovanny Rafael Duque, et al.
Published: (2025-07-01)

Is There a Role of 25-Hydroxy Vitamin D in the Pathogenesis of Mild and Moderate-to-Severe Endometriosis?
by: Nevin Tuten, et al.
Published: (2021-08-01)

Hydroxy-Selenomethionine Supplementation During Gestation and Lactation Improve Reproduction of Sows by Enhancing the Antioxidant Capacity and Immunity Under Heat Stress Conditions
by: Juan Wang, et al.
Published: (2025-04-01)

The Effect of New Water-soluble 2-aminoheteryl-3-ium 4-(het)aryl-2-hydroxy-4-oxobut-2-enoates on the Hemostasis System <i>In vitro</i>
by: A. V. Starkova, et al.
Published: (2023-12-01)

Parametric optimization of engine performance and emissions for hydroxy blended gaseous fuels
by: Muhammad Ali Ijaz Malik, et al.
Published: (2024-10-01)

Dietary Methionine Hydroxy Analog Regulates Hepatic Lipid Metabolism via SIRT1/AMPK Signaling Pathways in Largemouth Bass <i>Micropterus salmodies</i>
by: Ju Zhao, et al.
Published: (2025-02-01)

Veronica anagallis-aquatica L. iridoid glycosides alleviate heart failure via metabolites homoveratrumic acid and 2-hydroxy-3,4-dimethoxybenzoic acid mediated by the gut microbiota
by: Manjiong Wang, et al.
Published: (2025-06-01)

Aqueous-mediated synthesis of 2-amino-7-hydroxy-4-aryl-4H-chromene-3-carbonitrile derivatives using triethanolamine: An effective basic organocatalyst
by: Farzaneh Mohamadpour
Published: (2025-09-01)

Low-biomass pyruvate production with engineered Vibrio natriegens is accompanied by parapyruvate formation
by: Maurice Hädrich, et al.
Published: (2025-03-01)

A comparative study of the antioxidant activities of three series of first- and second-generation PPI dendrimers (G1 and G2) functionalized by2- hydroxy-P-naphthoquinone
by: El Hadji Gorgui DIOUF, et al.
Published: (2023-09-01)

CONCENTRATION AND TEMPERATURE DEPENDENCES IN EPR SPECTRA OD GD<sup>3+</sup> PROBE CENTERS IN THE Pb<sub>1-x</sub> Ag<sub>x</sub>S и Pb<sub>1-x</sub>Cu<sub>x</sub>S (0 ≤ x ≤ 0,011) THERMOELECTRIC CRYSTALS
by: A. M. Sinicin, et al.
Published: (2018-09-01)

Performances analysis of Sugar/EPR, Lithium Formate Monohydrate/EPR and Sulfamic acid/EPR dosimetry systems in evaluation of doses delivered during the prostate cancer treatment, using an anthropomorphic phantom
by: Fatna ZAHIRI, et al.
Published: (2025-04-01)