Gray and white matter alterations in Obsessive-Compulsive Personality Disorder: a data fusion machine learning approach
IntroductionObsessive-Compulsive Personality Disorder (OCPD) is a complex mental condition marked by excessive perfectionism, orderliness, and rigidity, often starting in adolescence or early adulthood; it affects 1.9% to 7.8% of the population. The disorder differs from Obsessive-Compulsive Disorde...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Human Neuroscience |
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| author | Lorenzo Arena Wenceslao Peñate Wenceslao Peñate Francisco Rivero Rosario J. Marrero Rosario J. Marrero Teresa Olivares Alessandro Scarano Ascensión Fumero Ascensión Fumero Alessandro Grecucci |
| author_facet | Lorenzo Arena Wenceslao Peñate Wenceslao Peñate Francisco Rivero Rosario J. Marrero Rosario J. Marrero Teresa Olivares Alessandro Scarano Ascensión Fumero Ascensión Fumero Alessandro Grecucci |
| author_sort | Lorenzo Arena |
| collection | DOAJ |
| description | IntroductionObsessive-Compulsive Personality Disorder (OCPD) is a complex mental condition marked by excessive perfectionism, orderliness, and rigidity, often starting in adolescence or early adulthood; it affects 1.9% to 7.8% of the population. The disorder differs from Obsessive-Compulsive Disorder (OCD) in an apparent compromise of personality, distorted self-representation, and altered perception of others. Although the two disorders present evident differences, unlike OCD, the neural bases of OCPD are understudied. The few studies conducted so far have identified gray matter alterations in brain regions such as the striatum and prefrontal cortex. However, a comprehensive model of its neurobiology and the eventual contribution of white matter abnormalities are still unclear. One intriguing hypothesis is that regions ascribed to the Default Mode Network are involved in OCPD, similar to what has been shown for OCD and other anxiety disorders.MethodsTo test this hypothesis, the gray and white matter images of 30 individuals diagnosed with OCPD (73% female, mean age=29.300), and 34 non-OCPD controls (82% female, mean age = 25.599) were analyzed for the first time with a data fusion unsupervised machine learning method known as Parallel Independent Component Analysis (pICA) to detect the joint contribution of these modalities to the OCPD diagnosis.ResultsResults indicated that two gray matter networks (GM-05 and GM-23) and one white matter network (WM-25) differed between the OCPD and the control group. GM-05 included brain regions belonging to the Default Mode Network and the Salience Network and was significantly correlated with anxiety; GM-23 included portions of the cerebellum, the precuneus, and the fusiform gyrus; WM-25 included white matter portions adjacent to Default Mode Network regions.DiscussionThese findings shed new light on the gray and white matter contributions to OCPD and may pave the way to developing objective markers of this disorder. |
| format | Article |
| id | doaj-art-a399f0c763b24f77afa1b46e65c02879 |
| institution | OA Journals |
| issn | 1662-5161 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
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| spelling | doaj-art-a399f0c763b24f77afa1b46e65c028792025-08-20T02:31:05ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612025-05-011910.3389/fnhum.2025.15597601559760Gray and white matter alterations in Obsessive-Compulsive Personality Disorder: a data fusion machine learning approachLorenzo Arena0Wenceslao Peñate1Wenceslao Peñate2Francisco Rivero3Rosario J. Marrero4Rosario J. Marrero5Teresa Olivares6Alessandro Scarano7Ascensión Fumero8Ascensión Fumero9Alessandro Grecucci10Department of Psychology and Cognitive Science, University of Trento, Trento, ItalyDepartamento de Psicología Clínica, Psicobiología y Metodología, Facultad de Psicología, Universidad de La Laguna, La Laguna, SpainInstituto Universitario De Neurociencia (IUNE), Universidad de La Laguna, La Laguna, SpainFacultad de Ciencias de la Salud, Universidad Europea de Canarias, La Orotava, SpainDepartamento de Psicología Clínica, Psicobiología y Metodología, Facultad de Psicología, Universidad de La Laguna, La Laguna, SpainInstituto Universitario De Neurociencia (IUNE), Universidad de La Laguna, La Laguna, SpainDepartamento de Psicología Clínica, Psicobiología y Metodología, Facultad de Psicología, Universidad de La Laguna, La Laguna, SpainDepartment of Psychology and Cognitive Science, University of Trento, Trento, ItalyDepartamento de Psicología Clínica, Psicobiología y Metodología, Facultad de Psicología, Universidad de La Laguna, La Laguna, SpainInstituto Universitario De Neurociencia (IUNE), Universidad de La Laguna, La Laguna, SpainDepartment of Psychology and Cognitive Science, University of Trento, Trento, ItalyIntroductionObsessive-Compulsive Personality Disorder (OCPD) is a complex mental condition marked by excessive perfectionism, orderliness, and rigidity, often starting in adolescence or early adulthood; it affects 1.9% to 7.8% of the population. The disorder differs from Obsessive-Compulsive Disorder (OCD) in an apparent compromise of personality, distorted self-representation, and altered perception of others. Although the two disorders present evident differences, unlike OCD, the neural bases of OCPD are understudied. The few studies conducted so far have identified gray matter alterations in brain regions such as the striatum and prefrontal cortex. However, a comprehensive model of its neurobiology and the eventual contribution of white matter abnormalities are still unclear. One intriguing hypothesis is that regions ascribed to the Default Mode Network are involved in OCPD, similar to what has been shown for OCD and other anxiety disorders.MethodsTo test this hypothesis, the gray and white matter images of 30 individuals diagnosed with OCPD (73% female, mean age=29.300), and 34 non-OCPD controls (82% female, mean age = 25.599) were analyzed for the first time with a data fusion unsupervised machine learning method known as Parallel Independent Component Analysis (pICA) to detect the joint contribution of these modalities to the OCPD diagnosis.ResultsResults indicated that two gray matter networks (GM-05 and GM-23) and one white matter network (WM-25) differed between the OCPD and the control group. GM-05 included brain regions belonging to the Default Mode Network and the Salience Network and was significantly correlated with anxiety; GM-23 included portions of the cerebellum, the precuneus, and the fusiform gyrus; WM-25 included white matter portions adjacent to Default Mode Network regions.DiscussionThese findings shed new light on the gray and white matter contributions to OCPD and may pave the way to developing objective markers of this disorder.https://www.frontiersin.org/articles/10.3389/fnhum.2025.1559760/fullObsessive-Compulsive Personality Disordermachine learningdata fusiongray matterwhite matter |
| spellingShingle | Lorenzo Arena Wenceslao Peñate Wenceslao Peñate Francisco Rivero Rosario J. Marrero Rosario J. Marrero Teresa Olivares Alessandro Scarano Ascensión Fumero Ascensión Fumero Alessandro Grecucci Gray and white matter alterations in Obsessive-Compulsive Personality Disorder: a data fusion machine learning approach Frontiers in Human Neuroscience Obsessive-Compulsive Personality Disorder machine learning data fusion gray matter white matter |
| title | Gray and white matter alterations in Obsessive-Compulsive Personality Disorder: a data fusion machine learning approach |
| title_full | Gray and white matter alterations in Obsessive-Compulsive Personality Disorder: a data fusion machine learning approach |
| title_fullStr | Gray and white matter alterations in Obsessive-Compulsive Personality Disorder: a data fusion machine learning approach |
| title_full_unstemmed | Gray and white matter alterations in Obsessive-Compulsive Personality Disorder: a data fusion machine learning approach |
| title_short | Gray and white matter alterations in Obsessive-Compulsive Personality Disorder: a data fusion machine learning approach |
| title_sort | gray and white matter alterations in obsessive compulsive personality disorder a data fusion machine learning approach |
| topic | Obsessive-Compulsive Personality Disorder machine learning data fusion gray matter white matter |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2025.1559760/full |
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