Significance of detecting antiphospholipid antibodies and genetic mutations of hemostasis for in vitro fertilization
A case of pregravid preparation is described for an in vitro fertilization (IVF) attempt in a woman after four previous IVF failures. Considering her personal and family aggravated medical history, including the family anamnesis, the patient underwent a hemostasis examination including a test for ge...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2019-09-01
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| Series: | Акушерство, гинекология и репродукция |
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| Online Access: | https://www.gynecology.su/jour/article/view/577 |
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| author | V. I. Linnikov |
| author_facet | V. I. Linnikov |
| author_sort | V. I. Linnikov |
| collection | DOAJ |
| description | A case of pregravid preparation is described for an in vitro fertilization (IVF) attempt in a woman after four previous IVF failures. Considering her personal and family aggravated medical history, including the family anamnesis, the patient underwent a hemostasis examination including a test for genetic mutations. A high titer of antiphospholipid antibodies of various types and multigene mutations associated with thrombophilia were found. For the treatment of acquired and inherited thrombophilia, vitamin-antioxidant and intravenous immunoglobulin therapy was initiated as well as a course of hirudotherapy. After starting of pregnancy throughout the gestation period, anticoagulant therapy by low molecular weight heparins, antiplatelet, and antioxidant therapy was carried out; in parallel, D-dimer, thrombin-antithrombin and platelet aggregation markers of thrombophilia were monitored. Pregnancy successfully ended by childbirth at 39 weeks. |
| format | Article |
| id | doaj-art-a396e7ae2b52467382efb764e62e34e1 |
| institution | Kabale University |
| issn | 2313-7347 2500-3194 |
| language | Russian |
| publishDate | 2019-09-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Акушерство, гинекология и репродукция |
| spelling | doaj-art-a396e7ae2b52467382efb764e62e34e12025-08-20T03:39:39ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942019-09-0113324024410.17749/2313-7347.2019.13.3.240-244512Significance of detecting antiphospholipid antibodies and genetic mutations of hemostasis for in vitro fertilizationV. I. Linnikov0Saint Paul German Medical and Diagnostic CenterA case of pregravid preparation is described for an in vitro fertilization (IVF) attempt in a woman after four previous IVF failures. Considering her personal and family aggravated medical history, including the family anamnesis, the patient underwent a hemostasis examination including a test for genetic mutations. A high titer of antiphospholipid antibodies of various types and multigene mutations associated with thrombophilia were found. For the treatment of acquired and inherited thrombophilia, vitamin-antioxidant and intravenous immunoglobulin therapy was initiated as well as a course of hirudotherapy. After starting of pregnancy throughout the gestation period, anticoagulant therapy by low molecular weight heparins, antiplatelet, and antioxidant therapy was carried out; in parallel, D-dimer, thrombin-antithrombin and platelet aggregation markers of thrombophilia were monitored. Pregnancy successfully ended by childbirth at 39 weeks.https://www.gynecology.su/jour/article/view/577antiphospholipid antibodiesacquired and genetic thrombophiliain vitro fertilization failureimmune therapyhirudotherapy |
| spellingShingle | V. I. Linnikov Significance of detecting antiphospholipid antibodies and genetic mutations of hemostasis for in vitro fertilization Акушерство, гинекология и репродукция antiphospholipid antibodies acquired and genetic thrombophilia in vitro fertilization failure immune therapy hirudotherapy |
| title | Significance of detecting antiphospholipid antibodies and genetic mutations of hemostasis for in vitro fertilization |
| title_full | Significance of detecting antiphospholipid antibodies and genetic mutations of hemostasis for in vitro fertilization |
| title_fullStr | Significance of detecting antiphospholipid antibodies and genetic mutations of hemostasis for in vitro fertilization |
| title_full_unstemmed | Significance of detecting antiphospholipid antibodies and genetic mutations of hemostasis for in vitro fertilization |
| title_short | Significance of detecting antiphospholipid antibodies and genetic mutations of hemostasis for in vitro fertilization |
| title_sort | significance of detecting antiphospholipid antibodies and genetic mutations of hemostasis for in vitro fertilization |
| topic | antiphospholipid antibodies acquired and genetic thrombophilia in vitro fertilization failure immune therapy hirudotherapy |
| url | https://www.gynecology.su/jour/article/view/577 |
| work_keys_str_mv | AT vilinnikov significanceofdetectingantiphospholipidantibodiesandgeneticmutationsofhemostasisforinvitrofertilization |