Novel pyrrole based triazole moiety as therapeutic hybrid: synthesis, characterization and anti-Alzheimer potential with molecular mechanism of protein ligand profile

Abstract As a springboard to explore novel potent inhibitors of cholinesterase enzymes (AChE and BChE) responsible for causing Alzheimer disorder, the current study was conducted to synthesize pyrrole derived triazole based Schiff base scaffolds by facile synthetic route. These compounds were valida...

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Bibliographic Details
Main Authors: Shoaib Khan, Tayyiaba Iqbal, Muhammad Bilal Khan, Rafaqat Hussain, Yousaf Khan, Hany W. Darwish
Format: Article
Language:English
Published: BMC 2024-11-01
Series:BMC Chemistry
Subjects:
Online Access:https://doi.org/10.1186/s13065-024-01340-x
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