Association of age, race, and ethnicity with access, response, and toxicities from CAR-T therapy in children and adults with B-cell malignancies: a review
Chimeric antigen receptor T cell (CAR-T) therapies are now standard-of-care for several B-cell malignancies, and additional indications are being evaluated. In this review, we survey data on how outcomes after CAR-T therapies vary according to age, race, and ethnicity. We also review the representat...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2025-01-01
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| Series: | Journal for ImmunoTherapy of Cancer |
| Online Access: | https://jitc.bmj.com/content/13/1/e009349.full |
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| author | Marco Ruella Guido Ghilardi Zainul S. Hasanali Sandra P. Susanibar-Adaniya Lena E. Winestone Alfred L. Garfall |
| author_facet | Marco Ruella Guido Ghilardi Zainul S. Hasanali Sandra P. Susanibar-Adaniya Lena E. Winestone Alfred L. Garfall |
| author_sort | Marco Ruella |
| collection | DOAJ |
| description | Chimeric antigen receptor T cell (CAR-T) therapies are now standard-of-care for several B-cell malignancies, and additional indications are being evaluated. In this review, we survey data on how outcomes after CAR-T therapies vary according to age, race, and ethnicity. We also review the representation of age, racial, and ethnic groups in key CAR-T clinical trials. We focus on B-cell acute lymphoblastic leukemia, B-cell non-Hodgkin’s lymphoma, and multiple myeloma. |
| format | Article |
| id | doaj-art-a389dc33e4cf493b9f8b75fd690efab5 |
| institution | Kabale University |
| issn | 2051-1426 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Journal for ImmunoTherapy of Cancer |
| spelling | doaj-art-a389dc33e4cf493b9f8b75fd690efab52025-02-10T06:05:13ZengBMJ Publishing GroupJournal for ImmunoTherapy of Cancer2051-14262025-01-0113110.1136/jitc-2024-009349Association of age, race, and ethnicity with access, response, and toxicities from CAR-T therapy in children and adults with B-cell malignancies: a reviewMarco Ruella0Guido Ghilardi1Zainul S. Hasanali2Sandra P. Susanibar-Adaniya3Lena E. Winestone4Alfred L. Garfall5University of Pennsylvania, Philadelphia, Pennsylvania, USA1 Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA2 Department of Medicine and Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA2 Department of Medicine and Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA3 Division of Allergy, Immunology, and BMT, Department of Pediatrics, University of California San Francisco, San Francisco, California, USA2 Department of Medicine and Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USAChimeric antigen receptor T cell (CAR-T) therapies are now standard-of-care for several B-cell malignancies, and additional indications are being evaluated. In this review, we survey data on how outcomes after CAR-T therapies vary according to age, race, and ethnicity. We also review the representation of age, racial, and ethnic groups in key CAR-T clinical trials. We focus on B-cell acute lymphoblastic leukemia, B-cell non-Hodgkin’s lymphoma, and multiple myeloma.https://jitc.bmj.com/content/13/1/e009349.full |
| spellingShingle | Marco Ruella Guido Ghilardi Zainul S. Hasanali Sandra P. Susanibar-Adaniya Lena E. Winestone Alfred L. Garfall Association of age, race, and ethnicity with access, response, and toxicities from CAR-T therapy in children and adults with B-cell malignancies: a review Journal for ImmunoTherapy of Cancer |
| title | Association of age, race, and ethnicity with access, response, and toxicities from CAR-T therapy in children and adults with B-cell malignancies: a review |
| title_full | Association of age, race, and ethnicity with access, response, and toxicities from CAR-T therapy in children and adults with B-cell malignancies: a review |
| title_fullStr | Association of age, race, and ethnicity with access, response, and toxicities from CAR-T therapy in children and adults with B-cell malignancies: a review |
| title_full_unstemmed | Association of age, race, and ethnicity with access, response, and toxicities from CAR-T therapy in children and adults with B-cell malignancies: a review |
| title_short | Association of age, race, and ethnicity with access, response, and toxicities from CAR-T therapy in children and adults with B-cell malignancies: a review |
| title_sort | association of age race and ethnicity with access response and toxicities from car t therapy in children and adults with b cell malignancies a review |
| url | https://jitc.bmj.com/content/13/1/e009349.full |
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