Risk of neurodevelopmental disorders in the offspring of mothers with a history of endometriosis in Taiwanese women
Several neurodevelopmental disorders have been linked to early life immune activation and inflammation, including developmental delay, cerebral palsy, intellectual disabilities, and other neurodevelopmental and psychiatric disorders. Certain inflammatory cytokines, such as interleukin-1β, interleuki...
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Elsevier
2025-08-01
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| Series: | Brain, Behavior, & Immunity - Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666354625000961 |
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| author | Pei-Yin Yang Ching-Ming Wang Pei-Lun Liao Jing-Yang Huang Keng-Wei Liang Yu-Hsuan Lin Shun-Fa Yang Po-Hui Wang |
| author_facet | Pei-Yin Yang Ching-Ming Wang Pei-Lun Liao Jing-Yang Huang Keng-Wei Liang Yu-Hsuan Lin Shun-Fa Yang Po-Hui Wang |
| author_sort | Pei-Yin Yang |
| collection | DOAJ |
| description | Several neurodevelopmental disorders have been linked to early life immune activation and inflammation, including developmental delay, cerebral palsy, intellectual disabilities, and other neurodevelopmental and psychiatric disorders. Certain inflammatory cytokines, such as interleukin-1β, interleukin-6, and tumor necrosis factor-α, secreted by endometriosis cells cause chronic pelvic inflammation and pain. The aim of this study was to evaluate whether maternal endometriosis increased the risk of neurodevelopmental disorders in offspring in Taiwanese women. The study included eligible mother–offspring pairs with maternal endometriosis (the case cohort) and mother–offspring pairs without maternal endometriosis (the comparison cohort) matched for maternal age at delivery, infant sex, and delivery date, both with offspring born during 2009–2016 and followed till 2019, from the Taiwan Maternal and Child Health Database. The incidence rates and crude hazard ratios (HRs) of development delay and cerebral palsy in the offspring delivered by mothers with endometriosis were higher than those in the offspring delivered by mothers without endometriosis (developmental delay: incidence 1.51 vs. 1.30 per 1000 person-months, crude HR = 1.16; cerebral palsy: incidence 0.04 vs. 0.03 per 1000 person-months, HR = 1.38). In model 1, the adjusted HRs of development delay and cerebral palsy in the offspring of mothers with endometriosis were 1.16 (95 % confidence interval [CI] = 1.11–1.22, P < 0.0001) and 1.39 (95 % CI = 1.04–1.85, P = 0.0256). In model 2, these were 1.11 (95 % CI = 1.06–1.17) and 1.01 (95 % CI = 0.76–1.36), respectively. However, the HRs of intellectual disabilities and other neurodevelopmental and psychiatric disorders were not significantly different between the offspring of mothers with and without endometriosis. In conclusion, maternal endometriosis may increase the risks of cerebral palsy and specifically developmental delay in offspring. |
| format | Article |
| id | doaj-art-a38182a147ee46a381f99c542a8d83df |
| institution | Kabale University |
| issn | 2666-3546 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj-art-a38182a147ee46a381f99c542a8d83df2025-08-20T03:31:34ZengElsevierBrain, Behavior, & Immunity - Health2666-35462025-08-014710103810.1016/j.bbih.2025.101038Risk of neurodevelopmental disorders in the offspring of mothers with a history of endometriosis in Taiwanese womenPei-Yin Yang0Ching-Ming Wang1Pei-Lun Liao2Jing-Yang Huang3Keng-Wei Liang4Yu-Hsuan Lin5Shun-Fa Yang6Po-Hui Wang7Institute of Medicine, Chung Shan Medical University, No. 110, Section 1, Chien-Kuo North Road, Taichung City, 40201, Taiwan; Department of Obstetrics and Gynecology, Changhua Christian Hospital, No 135, Nanxiao Street, Changhua, 50094, TaiwanNational Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, No.138, Sheng Li Road, Tainan City, 704, Taiwan; School of Medicine, College of Medicine, National Cheng Kung University, Cheng-Hsing Campus, No.1, University Road, Tainan City, 70101, TaiwanInstitute of Medicine, Chung Shan Medical University, No. 110, Section 1, Chien-Kuo North Road, Taichung City, 40201, Taiwan; Department of Medical Research, Chung Shan Medical University Hospital, No. 110, Section 1, Chien-Kuo North Road, Taichung City, 40201, Taiwan; Corresponding author. Institute of Medicine, Chung Shan Medical University, 110, Section 1, Chien-Kuo North Road, Taichung, 40201, Taiwan.Institute of Medicine, Chung Shan Medical University, No. 110, Section 1, Chien-Kuo North Road, Taichung City, 40201, Taiwan; Department of Medical Research, Chung Shan Medical University Hospital, No. 110, Section 1, Chien-Kuo North Road, Taichung City, 40201, TaiwanSchool of Medicine, Chung Shan Medical University, Taichung City, 40201, Taiwan; Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung City 40201, TaiwanDepartment of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung City, 40201, TaiwanInstitute of Medicine, Chung Shan Medical University, No. 110, Section 1, Chien-Kuo North Road, Taichung City, 40201, Taiwan; Department of Medical Research, Chung Shan Medical University Hospital, No. 110, Section 1, Chien-Kuo North Road, Taichung City, 40201, Taiwan; Corresponding author. Institute of Medicine, Chung Shan Medical University, 110, Section 1, Chien-Kuo North Road, Taichung, 40201, Taiwan.Institute of Medicine, Chung Shan Medical University, No. 110, Section 1, Chien-Kuo North Road, Taichung City, 40201, Taiwan; School of Medicine, Chung Shan Medical University, Taichung City, 40201, Taiwan; Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung City, 40201, Taiwan; Corresponding author. Institute of Medicine, Chung Shan Medical University, 110, Section 1, Chien-Kuo North Road, Taichung, 40201, Taiwan.Several neurodevelopmental disorders have been linked to early life immune activation and inflammation, including developmental delay, cerebral palsy, intellectual disabilities, and other neurodevelopmental and psychiatric disorders. Certain inflammatory cytokines, such as interleukin-1β, interleukin-6, and tumor necrosis factor-α, secreted by endometriosis cells cause chronic pelvic inflammation and pain. The aim of this study was to evaluate whether maternal endometriosis increased the risk of neurodevelopmental disorders in offspring in Taiwanese women. The study included eligible mother–offspring pairs with maternal endometriosis (the case cohort) and mother–offspring pairs without maternal endometriosis (the comparison cohort) matched for maternal age at delivery, infant sex, and delivery date, both with offspring born during 2009–2016 and followed till 2019, from the Taiwan Maternal and Child Health Database. The incidence rates and crude hazard ratios (HRs) of development delay and cerebral palsy in the offspring delivered by mothers with endometriosis were higher than those in the offspring delivered by mothers without endometriosis (developmental delay: incidence 1.51 vs. 1.30 per 1000 person-months, crude HR = 1.16; cerebral palsy: incidence 0.04 vs. 0.03 per 1000 person-months, HR = 1.38). In model 1, the adjusted HRs of development delay and cerebral palsy in the offspring of mothers with endometriosis were 1.16 (95 % confidence interval [CI] = 1.11–1.22, P < 0.0001) and 1.39 (95 % CI = 1.04–1.85, P = 0.0256). In model 2, these were 1.11 (95 % CI = 1.06–1.17) and 1.01 (95 % CI = 0.76–1.36), respectively. However, the HRs of intellectual disabilities and other neurodevelopmental and psychiatric disorders were not significantly different between the offspring of mothers with and without endometriosis. In conclusion, maternal endometriosis may increase the risks of cerebral palsy and specifically developmental delay in offspring.http://www.sciencedirect.com/science/article/pii/S2666354625000961Neurodevelopmental disordersDevelopmental delayCerebral palsyEndometriosisInflammation |
| spellingShingle | Pei-Yin Yang Ching-Ming Wang Pei-Lun Liao Jing-Yang Huang Keng-Wei Liang Yu-Hsuan Lin Shun-Fa Yang Po-Hui Wang Risk of neurodevelopmental disorders in the offspring of mothers with a history of endometriosis in Taiwanese women Brain, Behavior, & Immunity - Health Neurodevelopmental disorders Developmental delay Cerebral palsy Endometriosis Inflammation |
| title | Risk of neurodevelopmental disorders in the offspring of mothers with a history of endometriosis in Taiwanese women |
| title_full | Risk of neurodevelopmental disorders in the offspring of mothers with a history of endometriosis in Taiwanese women |
| title_fullStr | Risk of neurodevelopmental disorders in the offspring of mothers with a history of endometriosis in Taiwanese women |
| title_full_unstemmed | Risk of neurodevelopmental disorders in the offspring of mothers with a history of endometriosis in Taiwanese women |
| title_short | Risk of neurodevelopmental disorders in the offspring of mothers with a history of endometriosis in Taiwanese women |
| title_sort | risk of neurodevelopmental disorders in the offspring of mothers with a history of endometriosis in taiwanese women |
| topic | Neurodevelopmental disorders Developmental delay Cerebral palsy Endometriosis Inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S2666354625000961 |
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