Impact of IVF/ICSI on grades of placenta accreta spectrum disorders and pregnancy outcomes
Abstract Objective IVF/ICSI is associated with an increased risk of placenta accreta spectrum disorders (PAS). Invasive PAS can result in significant adverse maternal and fetal outcomes. This study investigates the impact of IVF/ICSI on the severity grading of PAS and its correlation with pregnancy...
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| Language: | English |
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BMC
2025-05-01
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| Series: | Reproductive Health |
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| Online Access: | https://doi.org/10.1186/s12978-025-02031-z |
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| author | Miao Hu Lili Du Lizi Zhang Lin Lin Yuliang Zhang Shifeng Gu Zhongjia Gu JingYing Liang Siying Lai Yu Liu Minshan Huang Yuanyuan Huang Qingqing Huang Shijun Luo Shuang Zhang Dunjin Chen |
| author_facet | Miao Hu Lili Du Lizi Zhang Lin Lin Yuliang Zhang Shifeng Gu Zhongjia Gu JingYing Liang Siying Lai Yu Liu Minshan Huang Yuanyuan Huang Qingqing Huang Shijun Luo Shuang Zhang Dunjin Chen |
| author_sort | Miao Hu |
| collection | DOAJ |
| description | Abstract Objective IVF/ICSI is associated with an increased risk of placenta accreta spectrum disorders (PAS). Invasive PAS can result in significant adverse maternal and fetal outcomes. This study investigates the impact of IVF/ICSI on the severity grading of PAS and its correlation with pregnancy complications. Methods Placenta accreta spectrum disorders (PAS) patients who underwent cesarean section at a single clinical center from January 2018 to March 2023 were retrospectively included in this study. Baseline characteristics and outcomes were compared between the IVF/ICSI group (154 cases) and the spontaneous conception group (820 cases). Binary logistic regression was used to explore the risk factors associated with adverse outcomes related to IVF/ICSI. A 1:1 ratio propensity score matching (PSM) was conducted to minimize selection bias between the two groups (123 cases per group). Data analysis was performed using SPSS (version 25.0) software. Results PAS grading is not associated with IVF/ICSI (OR = 0.76, 95%CI: 0.45 ~ 1.27, P = 0.290). In contrast, a significant risk factor for postpartum hemorrhage (OR = 9.20, 95%CI: 2.68 ~ 9.22, P < 0.001) and red cells transfusion ≥ 4U (OR = 3.71,95%CI:1.21 ~ 11.33, P = 0.021) was observed in IVF/ICSI group. No additional adverse pregnancy outcomes arose as a result of IVF/ICSI. Conclusion IVF/ICSI does not increase the depth of placental implantation in patients with placenta accreta spectrum (PAS); however, it is associated with a higher risk of postpartum hemorrhage and the need for blood transfusion. In clinical practice, special attention should be given to the prenatal management of these patients, along with ensuring adequate blood product reserves during delivery. |
| format | Article |
| id | doaj-art-a37ec8a0ba634bd78d96ca999218ecae |
| institution | Kabale University |
| issn | 1742-4755 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Health |
| spelling | doaj-art-a37ec8a0ba634bd78d96ca999218ecae2025-08-20T03:48:15ZengBMCReproductive Health1742-47552025-05-012211710.1186/s12978-025-02031-zImpact of IVF/ICSI on grades of placenta accreta spectrum disorders and pregnancy outcomesMiao Hu0Lili Du1Lizi Zhang2Lin Lin3Yuliang Zhang4Shifeng Gu5Zhongjia Gu6JingYing Liang7Siying Lai8Yu Liu9Minshan Huang10Yuanyuan Huang11Qingqing Huang12Shijun Luo13Shuang Zhang14Dunjin Chen15Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical UniversityDepartment of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical UniversityDepartment of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical UniversityDepartment of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical UniversityDepartment of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical UniversityDepartment of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical UniversityDepartment of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical UniversityDepartment of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical UniversityDepartment of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical UniversityDepartment of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical UniversityDepartment of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical UniversityDepartment of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical UniversityDepartment of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical UniversityDepartment of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical UniversityDepartment of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical UniversityDepartment of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical UniversityAbstract Objective IVF/ICSI is associated with an increased risk of placenta accreta spectrum disorders (PAS). Invasive PAS can result in significant adverse maternal and fetal outcomes. This study investigates the impact of IVF/ICSI on the severity grading of PAS and its correlation with pregnancy complications. Methods Placenta accreta spectrum disorders (PAS) patients who underwent cesarean section at a single clinical center from January 2018 to March 2023 were retrospectively included in this study. Baseline characteristics and outcomes were compared between the IVF/ICSI group (154 cases) and the spontaneous conception group (820 cases). Binary logistic regression was used to explore the risk factors associated with adverse outcomes related to IVF/ICSI. A 1:1 ratio propensity score matching (PSM) was conducted to minimize selection bias between the two groups (123 cases per group). Data analysis was performed using SPSS (version 25.0) software. Results PAS grading is not associated with IVF/ICSI (OR = 0.76, 95%CI: 0.45 ~ 1.27, P = 0.290). In contrast, a significant risk factor for postpartum hemorrhage (OR = 9.20, 95%CI: 2.68 ~ 9.22, P < 0.001) and red cells transfusion ≥ 4U (OR = 3.71,95%CI:1.21 ~ 11.33, P = 0.021) was observed in IVF/ICSI group. No additional adverse pregnancy outcomes arose as a result of IVF/ICSI. Conclusion IVF/ICSI does not increase the depth of placental implantation in patients with placenta accreta spectrum (PAS); however, it is associated with a higher risk of postpartum hemorrhage and the need for blood transfusion. In clinical practice, special attention should be given to the prenatal management of these patients, along with ensuring adequate blood product reserves during delivery.https://doi.org/10.1186/s12978-025-02031-zIVF/ICSIGrades of placentaOutcomesPostpartum hemorrhageTransfusion |
| spellingShingle | Miao Hu Lili Du Lizi Zhang Lin Lin Yuliang Zhang Shifeng Gu Zhongjia Gu JingYing Liang Siying Lai Yu Liu Minshan Huang Yuanyuan Huang Qingqing Huang Shijun Luo Shuang Zhang Dunjin Chen Impact of IVF/ICSI on grades of placenta accreta spectrum disorders and pregnancy outcomes Reproductive Health IVF/ICSI Grades of placenta Outcomes Postpartum hemorrhage Transfusion |
| title | Impact of IVF/ICSI on grades of placenta accreta spectrum disorders and pregnancy outcomes |
| title_full | Impact of IVF/ICSI on grades of placenta accreta spectrum disorders and pregnancy outcomes |
| title_fullStr | Impact of IVF/ICSI on grades of placenta accreta spectrum disorders and pregnancy outcomes |
| title_full_unstemmed | Impact of IVF/ICSI on grades of placenta accreta spectrum disorders and pregnancy outcomes |
| title_short | Impact of IVF/ICSI on grades of placenta accreta spectrum disorders and pregnancy outcomes |
| title_sort | impact of ivf icsi on grades of placenta accreta spectrum disorders and pregnancy outcomes |
| topic | IVF/ICSI Grades of placenta Outcomes Postpartum hemorrhage Transfusion |
| url | https://doi.org/10.1186/s12978-025-02031-z |
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