The Molecular Pathology of Pre-Eclamptic Hypertension
The central role of angiotensinogen in the control of blood pressure is revealed by a series of crystallographic structures, including complexes with renin. Specifically, the structures provide an understanding of the sequential molecular events that lead to the pre-eclamptic hypertensive crises of...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
|
| Series: | Current Issues in Molecular Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1467-3045/47/5/375 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850258047799132160 |
|---|---|
| author | Robin W. Carrell Randy J. Read Aiwu Zhou |
| author_facet | Robin W. Carrell Randy J. Read Aiwu Zhou |
| author_sort | Robin W. Carrell |
| collection | DOAJ |
| description | The central role of angiotensinogen in the control of blood pressure is revealed by a series of crystallographic structures, including complexes with renin. Specifically, the structures provide an understanding of the sequential molecular events that lead to the pre-eclamptic hypertensive crises of pregnancy. The release of the precursor vasopressor peptide from the amino-terminal tail of angiotensinogen appears to be modulated by a redox-sensitive disulphide bridge. Our findings indicate that the activation of the thiol-switch in the circulating maternal angiotensinogen occurs at the placental level in response to oxidative stress, exacerbated by placental insufficiency. We propose here that a contributory factor is the inherent redox stress accompanying the placental exchange of oxygenation between the haemoglobin of the mother (oxy-HbA) and the deoxygenated haemoglobin of the foetus (deoxy-HbF). |
| format | Article |
| id | doaj-art-a37d1dd111b547f18710a8a708a449e8 |
| institution | OA Journals |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj-art-a37d1dd111b547f18710a8a708a449e82025-08-20T01:56:16ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452025-05-0147537510.3390/cimb47050375The Molecular Pathology of Pre-Eclamptic HypertensionRobin W. Carrell0Randy J. Read1Aiwu Zhou2Department of Haematology, Cambridge Institute for Medical Research, Trinity College, University of Cambridge, Cambridge CB2 1TQ, UKDepartment of Haematology, Cambridge Institute for Medical Research, Trinity College, University of Cambridge, Cambridge CB2 1TQ, UKDepartment of Haematology, Cambridge Institute for Medical Research, Trinity College, University of Cambridge, Cambridge CB2 1TQ, UKThe central role of angiotensinogen in the control of blood pressure is revealed by a series of crystallographic structures, including complexes with renin. Specifically, the structures provide an understanding of the sequential molecular events that lead to the pre-eclamptic hypertensive crises of pregnancy. The release of the precursor vasopressor peptide from the amino-terminal tail of angiotensinogen appears to be modulated by a redox-sensitive disulphide bridge. Our findings indicate that the activation of the thiol-switch in the circulating maternal angiotensinogen occurs at the placental level in response to oxidative stress, exacerbated by placental insufficiency. We propose here that a contributory factor is the inherent redox stress accompanying the placental exchange of oxygenation between the haemoglobin of the mother (oxy-HbA) and the deoxygenated haemoglobin of the foetus (deoxy-HbF).https://www.mdpi.com/1467-3045/47/5/375angiotensinogenhypertensionpre-eclampsiaS-nitrosylationplacenta redox stress |
| spellingShingle | Robin W. Carrell Randy J. Read Aiwu Zhou The Molecular Pathology of Pre-Eclamptic Hypertension Current Issues in Molecular Biology angiotensinogen hypertension pre-eclampsia S-nitrosylation placenta redox stress |
| title | The Molecular Pathology of Pre-Eclamptic Hypertension |
| title_full | The Molecular Pathology of Pre-Eclamptic Hypertension |
| title_fullStr | The Molecular Pathology of Pre-Eclamptic Hypertension |
| title_full_unstemmed | The Molecular Pathology of Pre-Eclamptic Hypertension |
| title_short | The Molecular Pathology of Pre-Eclamptic Hypertension |
| title_sort | molecular pathology of pre eclamptic hypertension |
| topic | angiotensinogen hypertension pre-eclampsia S-nitrosylation placenta redox stress |
| url | https://www.mdpi.com/1467-3045/47/5/375 |
| work_keys_str_mv | AT robinwcarrell themolecularpathologyofpreeclamptichypertension AT randyjread themolecularpathologyofpreeclamptichypertension AT aiwuzhou themolecularpathologyofpreeclamptichypertension AT robinwcarrell molecularpathologyofpreeclamptichypertension AT randyjread molecularpathologyofpreeclamptichypertension AT aiwuzhou molecularpathologyofpreeclamptichypertension |