SleepNow – A combined cognitive behavioral therapy for insomnia and physical exercise intervention in men with metastatic prostate cancer: results from a feasibility randomized controlled trial
focused on patients living with metastatic cancer. We examined the feasibility of the SleepNow intervention combining cognitive behavioral therapy for insomnia (CBT-I) with physical exercise in men with metastatic prostate cancer (mPCa). Patients/material and methods: We conducted a feasibility ran...
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| Format: | Article |
| Language: | English |
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Medical Journals Sweden
2025-02-01
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| Series: | Acta Oncologica |
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| Online Access: | https://medicaljournalssweden.se/actaoncologica/article/view/42246 |
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| author | Beverley Lim Høeg Katrine Bjerre Løppenthin Josée Savard Christoffer Johansen Jesper Frank Christensen Mads Nordahl Svendsen Niels Holländer Pernille Envold Bidstrup |
| author_facet | Beverley Lim Høeg Katrine Bjerre Løppenthin Josée Savard Christoffer Johansen Jesper Frank Christensen Mads Nordahl Svendsen Niels Holländer Pernille Envold Bidstrup |
| author_sort | Beverley Lim Høeg |
| collection | DOAJ |
| description | focused on patients living with metastatic cancer. We examined the feasibility of the SleepNow intervention combining cognitive behavioral therapy for insomnia (CBT-I) with physical exercise in men with metastatic prostate cancer (mPCa).
Patients/material and methods: We conducted a feasibility randomized trial in patients under treatment for castration resistant mPCa with insomnia (Insomnia Severity Index [ISI] score ≥ 8). Patients were randomized 1:1 to either SleepNow or usual care. SleepNow is a manualized 12-week program consisting of bi-weekly sessions of physical exercise and four nurse-led sessions of CBT-I. Patients in usual care received no insomnia treatment. We assessed feasibility and measured objective and patient-reported outcomes at baseline and 3-months follow-up. Changes in both groups were compared using the Wilcoxon test.
Results: We randomized 12 patients (5 intervention and 7 control; age range = 59–81 years, mean Gleason score = 7.75, mean time since diagnosis ≈ 7 years). Intervention patients reported high satisfaction, all attended at least three CBT-I sessions (75%) and four completed at least 20 of the 24 training sessions. The intervention group showed improvements in insomnia, sleep quality, fatigue, anxiety, depression and health-related quality-of-life but between-group differences were not statistically significant.
Interpretation: The SleepNow intervention is the first to combine nurse-delivered CBT-I and physical exercise and was acceptable and potentially efficacious. Our results are important for targeting sleep interventions to the growing population of patients living long term with metastatic cancer.
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| format | Article |
| id | doaj-art-a379ecab830c44119dfdf87d7d8fca35 |
| institution | Kabale University |
| issn | 1651-226X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Oncologica |
| spelling | doaj-art-a379ecab830c44119dfdf87d7d8fca352025-02-10T07:00:35ZengMedical Journals SwedenActa Oncologica1651-226X2025-02-016410.2340/1651-226X.2025.42246SleepNow – A combined cognitive behavioral therapy for insomnia and physical exercise intervention in men with metastatic prostate cancer: results from a feasibility randomized controlled trialBeverley Lim Høeg0https://orcid.org/0000-0002-9946-2429Katrine Bjerre Løppenthin1Josée Savard2Christoffer JohansenJesper Frank ChristensenMads Nordahl SvendsenNiels HolländerPernille Envold BidstrupDanish Cancer InstituteDepartment of Oncology, Copenhagen University HospitalUniversité Laval and CHU de Québec-Université Laval Research Center, Québec, Canadafocused on patients living with metastatic cancer. We examined the feasibility of the SleepNow intervention combining cognitive behavioral therapy for insomnia (CBT-I) with physical exercise in men with metastatic prostate cancer (mPCa). Patients/material and methods: We conducted a feasibility randomized trial in patients under treatment for castration resistant mPCa with insomnia (Insomnia Severity Index [ISI] score ≥ 8). Patients were randomized 1:1 to either SleepNow or usual care. SleepNow is a manualized 12-week program consisting of bi-weekly sessions of physical exercise and four nurse-led sessions of CBT-I. Patients in usual care received no insomnia treatment. We assessed feasibility and measured objective and patient-reported outcomes at baseline and 3-months follow-up. Changes in both groups were compared using the Wilcoxon test. Results: We randomized 12 patients (5 intervention and 7 control; age range = 59–81 years, mean Gleason score = 7.75, mean time since diagnosis ≈ 7 years). Intervention patients reported high satisfaction, all attended at least three CBT-I sessions (75%) and four completed at least 20 of the 24 training sessions. The intervention group showed improvements in insomnia, sleep quality, fatigue, anxiety, depression and health-related quality-of-life but between-group differences were not statistically significant. Interpretation: The SleepNow intervention is the first to combine nurse-delivered CBT-I and physical exercise and was acceptable and potentially efficacious. Our results are important for targeting sleep interventions to the growing population of patients living long term with metastatic cancer. https://medicaljournalssweden.se/actaoncologica/article/view/42246insomniaexercisemetastatic cancercognitive behavioral therapyprostate cancer |
| spellingShingle | Beverley Lim Høeg Katrine Bjerre Løppenthin Josée Savard Christoffer Johansen Jesper Frank Christensen Mads Nordahl Svendsen Niels Holländer Pernille Envold Bidstrup SleepNow – A combined cognitive behavioral therapy for insomnia and physical exercise intervention in men with metastatic prostate cancer: results from a feasibility randomized controlled trial Acta Oncologica insomnia exercise metastatic cancer cognitive behavioral therapy prostate cancer |
| title | SleepNow – A combined cognitive behavioral therapy for insomnia and physical exercise intervention in men with metastatic prostate cancer: results from a feasibility randomized controlled trial |
| title_full | SleepNow – A combined cognitive behavioral therapy for insomnia and physical exercise intervention in men with metastatic prostate cancer: results from a feasibility randomized controlled trial |
| title_fullStr | SleepNow – A combined cognitive behavioral therapy for insomnia and physical exercise intervention in men with metastatic prostate cancer: results from a feasibility randomized controlled trial |
| title_full_unstemmed | SleepNow – A combined cognitive behavioral therapy for insomnia and physical exercise intervention in men with metastatic prostate cancer: results from a feasibility randomized controlled trial |
| title_short | SleepNow – A combined cognitive behavioral therapy for insomnia and physical exercise intervention in men with metastatic prostate cancer: results from a feasibility randomized controlled trial |
| title_sort | sleepnow a combined cognitive behavioral therapy for insomnia and physical exercise intervention in men with metastatic prostate cancer results from a feasibility randomized controlled trial |
| topic | insomnia exercise metastatic cancer cognitive behavioral therapy prostate cancer |
| url | https://medicaljournalssweden.se/actaoncologica/article/view/42246 |
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