8-Nitrotryptanthrin inhibits colorectal cancer progression via TGF-β/SMAD and PI3K/AKT/mTOR pathways

8-Nitrotryptanthrin inhibits colorectal cancer progression via TGF-β/SMAD and PI3K/AKT/mTOR pathways

ObjectiveTo investigate the anticancer effects and underlying mechanisms of 8-nitrotryptanthrin (8-Nitrotryp) against colorectal cancer (CRC).MethodsThe effects of 8-Nitrotryp on proliferation, colony formation, and migration were evaluated in HCT116 and SW480 cells, with comparisons to its parent c...

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Bibliographic Details
Main Authors:	Cheng-Yu Sun, Kai-Ping Cong, Dan-Dan Zhao, En-Guo Fan, Ming-Quan Guo, Zheng-Guo Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Series:	Frontiers in Pharmacology
Subjects:	colorectal neoplasms 8-nitrotryptanthrin signal transduction transforming growth factor beta phosphatidylinositol 3-kinases
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1576673/full
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