Research progress on the application of Lacticaseibacillus rhamnosus GG in pediatric respiratory diseases
Respiratory diseases are a leading cause of morbidity in children globally, with significant healthcare costs. The overuse of conventional treatments like antibiotics has raised concerns about antibiotic resistance and side effects. Lacticaseibacillus rhamnosus GG (LGG), one of the most extensively...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1553674/full |
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| author | Yang Liu Yang Liu Yang Liu Yang Liu Yan Chen Yan Chen Yan Chen Huijuan Liao Huijuan Liao Huijuan Liao Shijie Sun Shijie Sun Shijie Sun Xiaohu Zhang Xiaohu Zhang Xiaohu Zhang Xiaohu Zhang Liang Xie Liang Xie Liang Xie Liang Xie Hanmin Liu Hanmin Liu Hanmin Liu Hanmin Liu Hanmin Liu |
| author_facet | Yang Liu Yang Liu Yang Liu Yang Liu Yan Chen Yan Chen Yan Chen Huijuan Liao Huijuan Liao Huijuan Liao Shijie Sun Shijie Sun Shijie Sun Xiaohu Zhang Xiaohu Zhang Xiaohu Zhang Xiaohu Zhang Liang Xie Liang Xie Liang Xie Liang Xie Hanmin Liu Hanmin Liu Hanmin Liu Hanmin Liu Hanmin Liu |
| author_sort | Yang Liu |
| collection | DOAJ |
| description | Respiratory diseases are a leading cause of morbidity in children globally, with significant healthcare costs. The overuse of conventional treatments like antibiotics has raised concerns about antibiotic resistance and side effects. Lacticaseibacillus rhamnosus GG (LGG), one of the most extensively studied probiotics, has gained attention as a potential adjunct therapies due to their ability to modulate the gut microbiota and immune responses. This review aims to assess the effectiveness of LGG in managing pediatric respiratory diseases, including respiratory tract infections (RTI), cystic fibrosis (CF), and asthma. Clinical trials suggest LGG can reduce the incidence and severity of RTI, improving CF symptoms, and enhancing quality of life in children. However, evidence for its benefits in asthma remains inconclusive. Its mechanisms include modulating immune responses, enhancing gut barrier function, and maintaining a microbial homeostasis via the gut-lung axis. Existing studies are often limited by small sample sizes, heterogeneity in intervention protocols, and short follow-up periods. Emerging technologies and novel formulations, hold promise for unraveling the complex interactions among LGG, the gut-lung axis, and respiratory health. These advancements could pave the way for personalized probiotic therapies, highlighting the potential of LGG as a cost-effective, adjunctive therapy for pediatric respiratory diseases. This review underscores the broader significance of integrating LGG into pediatric healthcare, while calling for future research to overcome current limitations, optimize clinical protocols, and explore innovative therapeutic strategies. |
| format | Article |
| id | doaj-art-a37285ec5e3f4247bde911fb7b471cfa |
| institution | OA Journals |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-a37285ec5e3f4247bde911fb7b471cfa2025-08-20T02:15:30ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-02-011210.3389/fnut.2025.15536741553674Research progress on the application of Lacticaseibacillus rhamnosus GG in pediatric respiratory diseasesYang Liu0Yang Liu1Yang Liu2Yang Liu3Yan Chen4Yan Chen5Yan Chen6Huijuan Liao7Huijuan Liao8Huijuan Liao9Shijie Sun10Shijie Sun11Shijie Sun12Xiaohu Zhang13Xiaohu Zhang14Xiaohu Zhang15Xiaohu Zhang16Liang Xie17Liang Xie18Liang Xie19Liang Xie20Hanmin Liu21Hanmin Liu22Hanmin Liu23Hanmin Liu24Hanmin Liu25Department of Pediatric Pulmonology and Immunology, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, ChinaNHC Key Laboratory of Chronobiology (Sichuan University), Chengdu, ChinaThe Joint Laboratory for Lung Development and Related Diseases of West China Second University Hospital, Sichuan University and School of Life Sciences of Fudan University, West China Institute of Women and Children's Health, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, ChinaNHC Key Laboratory of Chronobiology (Sichuan University), Chengdu, ChinaSichuan University-The Chinese University of Hong Kong Joint Laboratory for Reproductive Medicine, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, ChinaNHC Key Laboratory of Chronobiology (Sichuan University), Chengdu, ChinaSichuan University-The Chinese University of Hong Kong Joint Laboratory for Reproductive Medicine, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, ChinaNHC Key Laboratory of Chronobiology (Sichuan University), Chengdu, ChinaSichuan University-The Chinese University of Hong Kong Joint Laboratory for Reproductive Medicine, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, ChinaNHC Key Laboratory of Chronobiology (Sichuan University), Chengdu, ChinaSichuan University-The Chinese University of Hong Kong Joint Laboratory for Reproductive Medicine, West China Second University Hospital, Sichuan University, Chengdu, ChinaDevelopment and Related Diseases of Women and Children Key Laboratory of Sichuan Province, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Pediatric Pulmonology and Immunology, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, ChinaNHC Key Laboratory of Chronobiology (Sichuan University), Chengdu, ChinaThe Joint Laboratory for Lung Development and Related Diseases of West China Second University Hospital, Sichuan University and School of Life Sciences of Fudan University, West China Institute of Women and Children's Health, West China Second University Hospital, Sichuan University, Chengdu, ChinaDepartment of Pediatric Pulmonology and Immunology, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, ChinaNHC Key Laboratory of Chronobiology (Sichuan University), Chengdu, ChinaThe Joint Laboratory for Lung Development and Related Diseases of West China Second University Hospital, Sichuan University and School of Life Sciences of Fudan University, West China Institute of Women and Children's Health, West China Second University Hospital, Sichuan University, Chengdu, ChinaDevelopment and Related Diseases of Women and Children Key Laboratory of Sichuan Province, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaRespiratory diseases are a leading cause of morbidity in children globally, with significant healthcare costs. The overuse of conventional treatments like antibiotics has raised concerns about antibiotic resistance and side effects. Lacticaseibacillus rhamnosus GG (LGG), one of the most extensively studied probiotics, has gained attention as a potential adjunct therapies due to their ability to modulate the gut microbiota and immune responses. This review aims to assess the effectiveness of LGG in managing pediatric respiratory diseases, including respiratory tract infections (RTI), cystic fibrosis (CF), and asthma. Clinical trials suggest LGG can reduce the incidence and severity of RTI, improving CF symptoms, and enhancing quality of life in children. However, evidence for its benefits in asthma remains inconclusive. Its mechanisms include modulating immune responses, enhancing gut barrier function, and maintaining a microbial homeostasis via the gut-lung axis. Existing studies are often limited by small sample sizes, heterogeneity in intervention protocols, and short follow-up periods. Emerging technologies and novel formulations, hold promise for unraveling the complex interactions among LGG, the gut-lung axis, and respiratory health. These advancements could pave the way for personalized probiotic therapies, highlighting the potential of LGG as a cost-effective, adjunctive therapy for pediatric respiratory diseases. This review underscores the broader significance of integrating LGG into pediatric healthcare, while calling for future research to overcome current limitations, optimize clinical protocols, and explore innovative therapeutic strategies.https://www.frontiersin.org/articles/10.3389/fnut.2025.1553674/fullLacticaseibacillus rhamnosus GGpediatricsrespiratory diseasesgut-lung axisprobioticsimmunomodulation |
| spellingShingle | Yang Liu Yang Liu Yang Liu Yang Liu Yan Chen Yan Chen Yan Chen Huijuan Liao Huijuan Liao Huijuan Liao Shijie Sun Shijie Sun Shijie Sun Xiaohu Zhang Xiaohu Zhang Xiaohu Zhang Xiaohu Zhang Liang Xie Liang Xie Liang Xie Liang Xie Hanmin Liu Hanmin Liu Hanmin Liu Hanmin Liu Hanmin Liu Research progress on the application of Lacticaseibacillus rhamnosus GG in pediatric respiratory diseases Frontiers in Nutrition Lacticaseibacillus rhamnosus GG pediatrics respiratory diseases gut-lung axis probiotics immunomodulation |
| title | Research progress on the application of Lacticaseibacillus rhamnosus GG in pediatric respiratory diseases |
| title_full | Research progress on the application of Lacticaseibacillus rhamnosus GG in pediatric respiratory diseases |
| title_fullStr | Research progress on the application of Lacticaseibacillus rhamnosus GG in pediatric respiratory diseases |
| title_full_unstemmed | Research progress on the application of Lacticaseibacillus rhamnosus GG in pediatric respiratory diseases |
| title_short | Research progress on the application of Lacticaseibacillus rhamnosus GG in pediatric respiratory diseases |
| title_sort | research progress on the application of lacticaseibacillus rhamnosus gg in pediatric respiratory diseases |
| topic | Lacticaseibacillus rhamnosus GG pediatrics respiratory diseases gut-lung axis probiotics immunomodulation |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1553674/full |
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