Re-emergence of H5N8 highly pathogenic avian influenza virus in wild birds, China
In mid-November 2020, deaths of whooper swan were reported in the Yellow River Reservoir Area, China. In the present study, we describe the genetic characterizations and phylogenetic relationships of four clade 2.3.4.4b H5N8 highly avian influenza viruses (HPAIVs) identified from a sick whooper swan...
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Taylor & Francis Group
2021-01-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2021.1968317 |
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| author | Juan Li Chunge Zhang Jian Cao Yongchun Yang Hui Dong Yanan Cui Xue Yao Hong Zhou Lu Lu Samantha Lycett Xiaodu Wang Houhui Song Wenjun Liu George F. Gao Weifeng Shi Yuhai Bi |
| author_facet | Juan Li Chunge Zhang Jian Cao Yongchun Yang Hui Dong Yanan Cui Xue Yao Hong Zhou Lu Lu Samantha Lycett Xiaodu Wang Houhui Song Wenjun Liu George F. Gao Weifeng Shi Yuhai Bi |
| author_sort | Juan Li |
| collection | DOAJ |
| description | In mid-November 2020, deaths of whooper swan were reported in the Yellow River Reservoir Area, China. In the present study, we describe the genetic characterizations and phylogenetic relationships of four clade 2.3.4.4b H5N8 highly avian influenza viruses (HPAIVs) identified from a sick whooper swan and environmental samples collected in the Yellow River Reservoir Area in late November 2020. They were closely related to recent H5Nx HPAIVs causing outbreaks in Eurasia in the 2020-2021 influenza season, suggesting these isolates might be imported into China via migratory birds. The newly identified H5N8 HPAIVs possessed Q226 and G228 (H3 numbering), indicating that they prefer to avian-like receptors. However, they had three mutations falling within known antigenic regions, including T144A in antigenic region A, T192I in antigenic region B, and N240D in antigenic region D. Our study highlights the risk of the rapid global spread of H5N8 HPAIVs and the necessity for continuous monitoring of avian influenza viruses in wild birds. |
| format | Article |
| id | doaj-art-a36c50bd95e4402780b8f929cf26d3aa |
| institution | OA Journals |
| issn | 2222-1751 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
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| series | Emerging Microbes and Infections |
| spelling | doaj-art-a36c50bd95e4402780b8f929cf26d3aa2025-08-20T02:24:43ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512021-01-011011819182310.1080/22221751.2021.1968317Re-emergence of H5N8 highly pathogenic avian influenza virus in wild birds, ChinaJuan Li0Chunge Zhang1Jian Cao2Yongchun Yang3Hui Dong4Yanan Cui5Xue Yao6Hong Zhou7Lu Lu8Samantha Lycett9Xiaodu Wang10Houhui Song11Wenjun Liu12George F. Gao13Weifeng Shi14Yuhai Bi15Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, People’s Republic of ChinaKey Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Lin’an, People’s Republic of ChinaCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, People’s Republic of ChinaKey Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Lin’an, People’s Republic of ChinaKey Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, People’s Republic of ChinaKey Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, People’s Republic of ChinaKey Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, People’s Republic of ChinaKey Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, People’s Republic of ChinaUsher Institute of Population Health Sciences & Informatics, Ashworth Laboratories, Kings Buildings, University of Edinburgh, Edinburgh, UKRoslin Institute, University of Edinburgh, Edinburgh, UKKey Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Lin’an, People’s Republic of ChinaKey Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Lin’an, People’s Republic of ChinaCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, People’s Republic of ChinaCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, People’s Republic of ChinaKey Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, People’s Republic of ChinaCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, People’s Republic of ChinaIn mid-November 2020, deaths of whooper swan were reported in the Yellow River Reservoir Area, China. In the present study, we describe the genetic characterizations and phylogenetic relationships of four clade 2.3.4.4b H5N8 highly avian influenza viruses (HPAIVs) identified from a sick whooper swan and environmental samples collected in the Yellow River Reservoir Area in late November 2020. They were closely related to recent H5Nx HPAIVs causing outbreaks in Eurasia in the 2020-2021 influenza season, suggesting these isolates might be imported into China via migratory birds. The newly identified H5N8 HPAIVs possessed Q226 and G228 (H3 numbering), indicating that they prefer to avian-like receptors. However, they had three mutations falling within known antigenic regions, including T144A in antigenic region A, T192I in antigenic region B, and N240D in antigenic region D. Our study highlights the risk of the rapid global spread of H5N8 HPAIVs and the necessity for continuous monitoring of avian influenza viruses in wild birds.https://www.tandfonline.com/doi/10.1080/22221751.2021.1968317Highly pathogenic avian influenza virus (HPAIV)H5N8clade 2.3.4.4bmigratory birdsre-emergence |
| spellingShingle | Juan Li Chunge Zhang Jian Cao Yongchun Yang Hui Dong Yanan Cui Xue Yao Hong Zhou Lu Lu Samantha Lycett Xiaodu Wang Houhui Song Wenjun Liu George F. Gao Weifeng Shi Yuhai Bi Re-emergence of H5N8 highly pathogenic avian influenza virus in wild birds, China Emerging Microbes and Infections Highly pathogenic avian influenza virus (HPAIV) H5N8 clade 2.3.4.4b migratory birds re-emergence |
| title | Re-emergence of H5N8 highly pathogenic avian influenza virus in wild birds, China |
| title_full | Re-emergence of H5N8 highly pathogenic avian influenza virus in wild birds, China |
| title_fullStr | Re-emergence of H5N8 highly pathogenic avian influenza virus in wild birds, China |
| title_full_unstemmed | Re-emergence of H5N8 highly pathogenic avian influenza virus in wild birds, China |
| title_short | Re-emergence of H5N8 highly pathogenic avian influenza virus in wild birds, China |
| title_sort | re emergence of h5n8 highly pathogenic avian influenza virus in wild birds china |
| topic | Highly pathogenic avian influenza virus (HPAIV) H5N8 clade 2.3.4.4b migratory birds re-emergence |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2021.1968317 |
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