Spatiotemporal Regulation of STING Activity by Linear Ubiquitination Governs Antiviral Immunity

Spatiotemporal Regulation of STING Activity by Linear Ubiquitination Governs Antiviral Immunity

Abstract The cyclic GMP‐AMP synthase (cGAS)‐stimulator of interferon gene protein (STING) signaling plays a critical role in innate immunity and must be tightly regulated to maintain immune homeostasis, but the mechanism underlying the spatiotemporal regulation of this pathway remains largely elusiv...

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Main Authors: Yong Zhang, Yesheng Fu, Lihua Qiang, Mengyuan Zhao, Zhe Lu, Zhuo Zhao, Guoping Chen, Zehui Lei, Qiyao Chai, Pupu Ge, Bingxi Li, Jing Wang, Cui Hua Liu, Lingqiang Zhang
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Advanced Science
Subjects:
antiviral immunity
HOIP
linear ubiquitination
OTULIN
STING
Online Access:https://doi.org/10.1002/advs.202417660
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