Comparison of angiotensin converting enzyme 1 levels to the grading of knee osteoarthritis
Background and aim. One of the most prevalent chronic joint illnesses is osteoarthritis (OA), which can impair a patient's quality of life by causing joint pain, stiffness, deformity, and narrowed joint spaces. Many factors influence the pathogenesis of Osteoarthritis such as age and body weigh...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Amaltea Medical Publishing House
2024-06-01
|
| Series: | Romanian Medical Journal |
| Subjects: | |
| Online Access: | https://rmj.com.ro/articles/2024.2/RMJ_2024_2_Art-02.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850122803820363776 |
|---|---|
| author | Fidelia Elvira Da Costa Rao Femi Syahriani Haerani Rasyid Syakib Bakri Harun Iskandar M. Nasser Mustari Gerald Wonggokusuma Andi A. Zainuddin |
| author_facet | Fidelia Elvira Da Costa Rao Femi Syahriani Haerani Rasyid Syakib Bakri Harun Iskandar M. Nasser Mustari Gerald Wonggokusuma Andi A. Zainuddin |
| author_sort | Fidelia Elvira Da Costa Rao |
| collection | DOAJ |
| description | Background and aim. One of the most prevalent chronic joint illnesses is osteoarthritis (OA), which can impair a patient's quality of life by causing joint pain, stiffness, deformity, and narrowed joint spaces. Many factors influence the pathogenesis of Osteoarthritis such as age and body weight, as well as genetic factors that are reported to play a role in the occurrence and progression of Osteoarthritis. Recently, many studies have demonstrated that inflammatory variables contribute to osteoarthritis pathomechanisms. It is currently thought that inflammatory variables alone are an independent risk factor for osteoarthritis. Methods. Observational sub-analysis with a cross-sectional approach to examine the relationship between Angiotensin Converting Enzyme 1 (ACE 1) levels and the grading of osteoarthritis at “Dr. Wahidin Sudirohusodo” Hospital from October 2020 to February 2021. ACE 1 levels were measured using the Elisa KIT and grading of osteoarthritis using the Kellgren and Lawrence criteria. Results. Analysis of the relationship between ACE 1 levels and osteoarthritis grading using the ANOVA test and Post Hoc Bonferonni Test showed a significant relationship between ACE 1 levels and osteoarthritis grading, where high ACE 1 levels were related to osteoarthritis grading. Deficiency and insufficiency (p<0.05). The results of this study are in line with previous research. Conclusion. The higher the ACE 1 level, the more severe the degree of knee osteoarthritis. |
| format | Article |
| id | doaj-art-a3657c8c8b0746ad8ee33ddec8c1f198 |
| institution | OA Journals |
| issn | 1220-5478 2069-606X |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Medical Journal |
| spelling | doaj-art-a3657c8c8b0746ad8ee33ddec8c1f1982025-08-20T02:34:46ZengAmaltea Medical Publishing HouseRomanian Medical Journal1220-54782069-606X2024-06-0171210010410.37897/RMJ.2024.2.2Comparison of angiotensin converting enzyme 1 levels to the grading of knee osteoarthritisFidelia Elvira Da Costa Rao0https://orcid.org/0009-0002-3529-6801Femi Syahriani1Haerani Rasyid2Syakib Bakri3Harun Iskandar4M. Nasser Mustari5Gerald Wonggokusuma6Andi A. Zainuddin7Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, IndonesiaDepartment of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, IndonesiaDepartment of Orthopedic and Traumatology, Faculty of Medicine, Hasanuddin University, Makassar, IndonesiaDepartment of Public Health and Community Medicine, Faculty of Medicine, Hasanuddin University, Makassar, IndonesiaBackground and aim. One of the most prevalent chronic joint illnesses is osteoarthritis (OA), which can impair a patient's quality of life by causing joint pain, stiffness, deformity, and narrowed joint spaces. Many factors influence the pathogenesis of Osteoarthritis such as age and body weight, as well as genetic factors that are reported to play a role in the occurrence and progression of Osteoarthritis. Recently, many studies have demonstrated that inflammatory variables contribute to osteoarthritis pathomechanisms. It is currently thought that inflammatory variables alone are an independent risk factor for osteoarthritis. Methods. Observational sub-analysis with a cross-sectional approach to examine the relationship between Angiotensin Converting Enzyme 1 (ACE 1) levels and the grading of osteoarthritis at “Dr. Wahidin Sudirohusodo” Hospital from October 2020 to February 2021. ACE 1 levels were measured using the Elisa KIT and grading of osteoarthritis using the Kellgren and Lawrence criteria. Results. Analysis of the relationship between ACE 1 levels and osteoarthritis grading using the ANOVA test and Post Hoc Bonferonni Test showed a significant relationship between ACE 1 levels and osteoarthritis grading, where high ACE 1 levels were related to osteoarthritis grading. Deficiency and insufficiency (p<0.05). The results of this study are in line with previous research. Conclusion. The higher the ACE 1 level, the more severe the degree of knee osteoarthritis.https://rmj.com.ro/articles/2024.2/RMJ_2024_2_Art-02.pdface1angiotensinrenin angiotensin systemosteoarthritisknee osteoarthritis grading |
| spellingShingle | Fidelia Elvira Da Costa Rao Femi Syahriani Haerani Rasyid Syakib Bakri Harun Iskandar M. Nasser Mustari Gerald Wonggokusuma Andi A. Zainuddin Comparison of angiotensin converting enzyme 1 levels to the grading of knee osteoarthritis Romanian Medical Journal ace1 angiotensin renin angiotensin system osteoarthritis knee osteoarthritis grading |
| title | Comparison of angiotensin converting enzyme 1 levels to the grading of knee osteoarthritis |
| title_full | Comparison of angiotensin converting enzyme 1 levels to the grading of knee osteoarthritis |
| title_fullStr | Comparison of angiotensin converting enzyme 1 levels to the grading of knee osteoarthritis |
| title_full_unstemmed | Comparison of angiotensin converting enzyme 1 levels to the grading of knee osteoarthritis |
| title_short | Comparison of angiotensin converting enzyme 1 levels to the grading of knee osteoarthritis |
| title_sort | comparison of angiotensin converting enzyme 1 levels to the grading of knee osteoarthritis |
| topic | ace1 angiotensin renin angiotensin system osteoarthritis knee osteoarthritis grading |
| url | https://rmj.com.ro/articles/2024.2/RMJ_2024_2_Art-02.pdf |
| work_keys_str_mv | AT fideliaelviradacostarao comparisonofangiotensinconvertingenzyme1levelstothegradingofkneeosteoarthritis AT femisyahriani comparisonofangiotensinconvertingenzyme1levelstothegradingofkneeosteoarthritis AT haeranirasyid comparisonofangiotensinconvertingenzyme1levelstothegradingofkneeosteoarthritis AT syakibbakri comparisonofangiotensinconvertingenzyme1levelstothegradingofkneeosteoarthritis AT haruniskandar comparisonofangiotensinconvertingenzyme1levelstothegradingofkneeosteoarthritis AT mnassermustari comparisonofangiotensinconvertingenzyme1levelstothegradingofkneeosteoarthritis AT geraldwonggokusuma comparisonofangiotensinconvertingenzyme1levelstothegradingofkneeosteoarthritis AT andiazainuddin comparisonofangiotensinconvertingenzyme1levelstothegradingofkneeosteoarthritis |