Cardiac Glycosides Activate the Tumor Suppressor and Viral Restriction Factor Promyelocytic Leukemia Protein (PML).

Cardiac glycosides (CGs), inhibitors of Na+/K+-ATPase (NKA), used clinically to treat heart failure, have garnered recent attention as potential anti-cancer and anti-viral agents. A high-throughput phenotypic screen designed to identify modulators of promyelocytic leukemia protein (PML) nuclear body...

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Bibliographic Details
Main Authors: Snezana Milutinovic, Susanne Heynen-Genel, Elizabeth Chao, Antimone Dewing, Ricardo Solano, Loribelle Milan, Nikki Barron, Min He, Paul W Diaz, Shu-ichi Matsuzawa, John C Reed, Christian A Hassig
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0152692&type=printable
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