Cardiac Glycosides Activate the Tumor Suppressor and Viral Restriction Factor Promyelocytic Leukemia Protein (PML).

Cardiac Glycosides Activate the Tumor Suppressor and Viral Restriction Factor Promyelocytic Leukemia Protein (PML).

Cardiac glycosides (CGs), inhibitors of Na+/K+-ATPase (NKA), used clinically to treat heart failure, have garnered recent attention as potential anti-cancer and anti-viral agents. A high-throughput phenotypic screen designed to identify modulators of promyelocytic leukemia protein (PML) nuclear body...

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Bibliographic Details
Main Authors: Snezana Milutinovic, Susanne Heynen-Genel, Elizabeth Chao, Antimone Dewing, Ricardo Solano, Loribelle Milan, Nikki Barron, Min He, Paul W Diaz, Shu-ichi Matsuzawa, John C Reed, Christian A Hassig
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0152692&type=printable
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