New insights into the generation and function of megakaryocytes in health and disease
Megakaryocytes (MKs) are canonically viewed as specialized hematopoietic cells merely producing platelets and generated through a series of hematopoietic stem and progenitor cells in the bone marrow (BM). Despite essential physiological functions, the generation and function of MKs remain incomplet...
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Ferrata Storti Foundation
2025-03-01
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| Series: | Haematologica |
| Online Access: | https://haematologica.org/article/view/12004 |
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| author | Changhong Du Jun Chen Junping Wang |
| author_facet | Changhong Du Jun Chen Junping Wang |
| author_sort | Changhong Du |
| collection | DOAJ |
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Megakaryocytes (MKs) are canonically viewed as specialized hematopoietic cells merely producing platelets and generated through a series of hematopoietic stem and progenitor cells in the bone marrow (BM). Despite essential physiological functions, the generation and function of MKs remain incompletely understood. Recent studies, almost in mice, have begun to redefine the cellular hierarchy of megakaryopoiesis, and shed new light on the alternative routes and mechanisms of megakaryopoiesis. Moreover, the conception of MKs as a homogenous cell population with the sole purpose of platelet production is being challenged. Conversely, MKs are shown to be a heterogenous cell population with distinct differentiation routes and versatile functions. Especially, MKs show abilities reminiscent of immune cells, and are increasingly considered as the root dictating the hemostatic and immune functions of platelets in various physiopathological conditions. Furthermore, although been well known as a component of the BM niche maintaining hematopoietic stem cells (HSCs) during homeostasis, the newly-identified properties of MKs further make them a key supporter for stressed or diseased HSCs during myeloablative injury, aging and hematopoietic malignancy. Therefore, the generation and function of MKs are more diverse than we previously thought. Here, we review the recent literatures that expand our views of MK differentiation and heterogeneity, as well as of MK functions with special focuses on their immune functions and supporting roles for stressed or diseased HSCs.
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| format | Article |
| id | doaj-art-a3632f9fba664b579053f83f2e9a2b16 |
| institution | DOAJ |
| issn | 0390-6078 1592-8721 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Ferrata Storti Foundation |
| record_format | Article |
| series | Haematologica |
| spelling | doaj-art-a3632f9fba664b579053f83f2e9a2b162025-08-20T02:54:04ZengFerrata Storti FoundationHaematologica0390-60781592-87212025-03-01999110.3324/haematol.2024.287236New insights into the generation and function of megakaryocytes in health and diseaseChanghong Du0Jun Chen1Junping Wang2State Key Laboratory of Trauma and Chemical Poisoning, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing, 400038State Key Laboratory of Trauma and Chemical Poisoning, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing, 400038State Key Laboratory of Trauma and Chemical Poisoning, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing, 400038 Megakaryocytes (MKs) are canonically viewed as specialized hematopoietic cells merely producing platelets and generated through a series of hematopoietic stem and progenitor cells in the bone marrow (BM). Despite essential physiological functions, the generation and function of MKs remain incompletely understood. Recent studies, almost in mice, have begun to redefine the cellular hierarchy of megakaryopoiesis, and shed new light on the alternative routes and mechanisms of megakaryopoiesis. Moreover, the conception of MKs as a homogenous cell population with the sole purpose of platelet production is being challenged. Conversely, MKs are shown to be a heterogenous cell population with distinct differentiation routes and versatile functions. Especially, MKs show abilities reminiscent of immune cells, and are increasingly considered as the root dictating the hemostatic and immune functions of platelets in various physiopathological conditions. Furthermore, although been well known as a component of the BM niche maintaining hematopoietic stem cells (HSCs) during homeostasis, the newly-identified properties of MKs further make them a key supporter for stressed or diseased HSCs during myeloablative injury, aging and hematopoietic malignancy. Therefore, the generation and function of MKs are more diverse than we previously thought. Here, we review the recent literatures that expand our views of MK differentiation and heterogeneity, as well as of MK functions with special focuses on their immune functions and supporting roles for stressed or diseased HSCs. https://haematologica.org/article/view/12004 |
| spellingShingle | Changhong Du Jun Chen Junping Wang New insights into the generation and function of megakaryocytes in health and disease Haematologica |
| title | New insights into the generation and function of megakaryocytes in health and disease |
| title_full | New insights into the generation and function of megakaryocytes in health and disease |
| title_fullStr | New insights into the generation and function of megakaryocytes in health and disease |
| title_full_unstemmed | New insights into the generation and function of megakaryocytes in health and disease |
| title_short | New insights into the generation and function of megakaryocytes in health and disease |
| title_sort | new insights into the generation and function of megakaryocytes in health and disease |
| url | https://haematologica.org/article/view/12004 |
| work_keys_str_mv | AT changhongdu newinsightsintothegenerationandfunctionofmegakaryocytesinhealthanddisease AT junchen newinsightsintothegenerationandfunctionofmegakaryocytesinhealthanddisease AT junpingwang newinsightsintothegenerationandfunctionofmegakaryocytesinhealthanddisease |