Evaluation of the Therapeutic Effects of Thymbra Spicata L. var spicata and Cyclotrichium Origanifolium in Spinal Cord Injury: An Experimental Study
Aim: Secondary tissue damage caused by oxidative stress and inflammation in spinal cord injury complicates treatment and highlights the need for novel therapeutic agents. This study aimed to evaluate the potential effects of Thymbra spicata L. var. spicata (zahter) and Cyclotrichium origanifolium (m...
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Duzce University
2025-08-01
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| Series: | Düzce Tıp Fakültesi Dergisi |
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| Online Access: | https://dergipark.org.tr/en/download/article-file/4486619 |
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| author | Hüseyin Özevren Dilek Aygün Keşim Engin Deveci M. Cudi Tuncer Figen Koç Direk |
| author_facet | Hüseyin Özevren Dilek Aygün Keşim Engin Deveci M. Cudi Tuncer Figen Koç Direk |
| author_sort | Hüseyin Özevren |
| collection | DOAJ |
| description | Aim: Secondary tissue damage caused by oxidative stress and inflammation in spinal cord injury complicates treatment and highlights the need for novel therapeutic agents. This study aimed to evaluate the potential effects of Thymbra spicata L. var. spicata (zahter) and Cyclotrichium origanifolium (mountain mint) extracts in an experimental SCI model.Material and Methods: Thirty-six male Wistar albino rats were randomly assigned to six groups: control, zahter, mountain mint, trauma, trauma+zahter, and trauma+mountain mint. Spinal cord injury was induced in the trauma groups. Blood was collected via cardiac puncture, and spinal tissues were obtained for histopathological and immunohistochemical analyses. Serum MDA, TAS, and TOS levels were measured biochemically. VEGF and GFAP expressions were assessed immunohistochemically.Results: MDA and TOS levels decreased, while TAS levels increased in the treated groups compared to the trauma group, but these changes were not found statistically significant. Histopathological evaluation showed prominent neuronal degeneration, inflammation, and vascular dilatation in the trauma group, which were alleviated in the treatment groups. Greater histological improvement was observed in the trauma+mountain mint group compared to trauma+zahter (p<0.001). VEGF and GFAP expressions were elevated in the trauma group but statistically significantly reduced in the treatment groups (p<0.001).Conclusion: Zahter and mountain mint extracts exhibited therapeutic potential against trauma-induced spinal cord injury by modulating inflammation and tissue damage. Mountain mint was found to be more effective in terms of histological and immunohistochemical outcomes. |
| format | Article |
| id | doaj-art-a3622fa4ad9b4f0fa61a6da1afa78dcd |
| institution | Kabale University |
| issn | 1307-671X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Duzce University |
| record_format | Article |
| series | Düzce Tıp Fakültesi Dergisi |
| spelling | doaj-art-a3622fa4ad9b4f0fa61a6da1afa78dcd2025-08-25T14:51:25ZengDuzce UniversityDüzce Tıp Fakültesi Dergisi1307-671X2025-08-0127213714510.18678/dtfd.161189797Evaluation of the Therapeutic Effects of Thymbra Spicata L. var spicata and Cyclotrichium Origanifolium in Spinal Cord Injury: An Experimental StudyHüseyin Özevren0https://orcid.org/0000-0002-5437-4003Dilek Aygün Keşim1https://orcid.org/0000-0001-5481-1130Engin Deveci2https://orcid.org/0000-0002-2353-1184M. Cudi Tuncer3https://orcid.org/0000-0001-7317-5467Figen Koç Direk4https://orcid.org/0000-0002-4748-2110DİCLE ÜNİVERSİTESİDİCLE ÜNİVERSİTESİDİCLE ÜNİVERSİTESİDİCLE ÜNİVERSİTESİMardin Artuklu ÜniversitesiAim: Secondary tissue damage caused by oxidative stress and inflammation in spinal cord injury complicates treatment and highlights the need for novel therapeutic agents. This study aimed to evaluate the potential effects of Thymbra spicata L. var. spicata (zahter) and Cyclotrichium origanifolium (mountain mint) extracts in an experimental SCI model.Material and Methods: Thirty-six male Wistar albino rats were randomly assigned to six groups: control, zahter, mountain mint, trauma, trauma+zahter, and trauma+mountain mint. Spinal cord injury was induced in the trauma groups. Blood was collected via cardiac puncture, and spinal tissues were obtained for histopathological and immunohistochemical analyses. Serum MDA, TAS, and TOS levels were measured biochemically. VEGF and GFAP expressions were assessed immunohistochemically.Results: MDA and TOS levels decreased, while TAS levels increased in the treated groups compared to the trauma group, but these changes were not found statistically significant. Histopathological evaluation showed prominent neuronal degeneration, inflammation, and vascular dilatation in the trauma group, which were alleviated in the treatment groups. Greater histological improvement was observed in the trauma+mountain mint group compared to trauma+zahter (p<0.001). VEGF and GFAP expressions were elevated in the trauma group but statistically significantly reduced in the treatment groups (p<0.001).Conclusion: Zahter and mountain mint extracts exhibited therapeutic potential against trauma-induced spinal cord injury by modulating inflammation and tissue damage. Mountain mint was found to be more effective in terms of histological and immunohistochemical outcomes.https://dergipark.org.tr/en/download/article-file/4486619antioksidanlaromurilik yaralanmasıoksidatif stresbitki ekstraktlarıtravmaantioxidantsspinal cord injuryoxidative stressplant extractstrauma |
| spellingShingle | Hüseyin Özevren Dilek Aygün Keşim Engin Deveci M. Cudi Tuncer Figen Koç Direk Evaluation of the Therapeutic Effects of Thymbra Spicata L. var spicata and Cyclotrichium Origanifolium in Spinal Cord Injury: An Experimental Study Düzce Tıp Fakültesi Dergisi antioksidanlar omurilik yaralanması oksidatif stres bitki ekstraktları travma antioxidants spinal cord injury oxidative stress plant extracts trauma |
| title | Evaluation of the Therapeutic Effects of Thymbra Spicata L. var spicata and Cyclotrichium Origanifolium in Spinal Cord Injury: An Experimental Study |
| title_full | Evaluation of the Therapeutic Effects of Thymbra Spicata L. var spicata and Cyclotrichium Origanifolium in Spinal Cord Injury: An Experimental Study |
| title_fullStr | Evaluation of the Therapeutic Effects of Thymbra Spicata L. var spicata and Cyclotrichium Origanifolium in Spinal Cord Injury: An Experimental Study |
| title_full_unstemmed | Evaluation of the Therapeutic Effects of Thymbra Spicata L. var spicata and Cyclotrichium Origanifolium in Spinal Cord Injury: An Experimental Study |
| title_short | Evaluation of the Therapeutic Effects of Thymbra Spicata L. var spicata and Cyclotrichium Origanifolium in Spinal Cord Injury: An Experimental Study |
| title_sort | evaluation of the therapeutic effects of thymbra spicata l var spicata and cyclotrichium origanifolium in spinal cord injury an experimental study |
| topic | antioksidanlar omurilik yaralanması oksidatif stres bitki ekstraktları travma antioxidants spinal cord injury oxidative stress plant extracts trauma |
| url | https://dergipark.org.tr/en/download/article-file/4486619 |
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