Evaluation of non-alcoholic fatty liver disease in patients with inflammatory bowel disease using controlled attenuation parameter technology: A Taiwanese retrospective cohort study.
<h4>Background/purpose</h4>An increased prevalence of non-alcoholic fatty liver disease (NAFLD) is observed in patients with inflammatory bowel disease (IBD) in Western countries. Both intestinal inflammation and metabolic factors contribute to the pathogenesis of IBD-associated NAFLD. T...
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2021-01-01
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| author | Hsu-Heng Yen Pei-Yuan Su Siou-Ping Huang Lisha Wu Tsui-Chun Hsu Ya-Huei Zeng Yang-Yuan Chen |
| author_facet | Hsu-Heng Yen Pei-Yuan Su Siou-Ping Huang Lisha Wu Tsui-Chun Hsu Ya-Huei Zeng Yang-Yuan Chen |
| author_sort | Hsu-Heng Yen |
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| description | <h4>Background/purpose</h4>An increased prevalence of non-alcoholic fatty liver disease (NAFLD) is observed in patients with inflammatory bowel disease (IBD) in Western countries. Both intestinal inflammation and metabolic factors contribute to the pathogenesis of IBD-associated NAFLD. The burden of NAFLD is not clear in the Asian population. This study aimed to evaluate the prevalence of NAFLD and liver fibrosis in a cohort of Taiwanese patients with IBD.<h4>Methods</h4>From January to December 2019, patients with IBD who underwent ultrasound examination were enrolled. Hepatic steatosis and fibrosis were measured with liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) using FibroScan. Patients with a history of excessive alcohol or recent steroid use were excluded. Univariate and multivariate analysis were performed.<h4>Results</h4>A total of 81 consecutive patients were enrolled and included in the analysis (45 with ulcerative colitis, 36 with Crohn's disease). The median age was 42 years old. The patients were classified in terms of body mass index as normal weight (54.3%), underweight (11.1%), overweight (28.4%), and obese (6.2%). The mean CAP increased to 162.22 dB/m in the underweight group, 210.86 dB/m in the normal weight group, 260.7 dB/m in the overweight group, and 274.0 dB/m in the obese group. NAFLD was observed in 29.6% of the patients, 1.2% of which had significant fibrosis. Increased body mass index (odds ratio [OR] 1.33, 95% confidence interval [CI] 1.1-1.62) and older age at IBD diagnosis (OR: 1.05, 95% CI 1-1.11) was found to be associated with the presence of NAFLD.<h4>Conclusion</h4>In this study, the prevalence of NAFLD was lower (29.6%) in IBD patients than in the Western population. Higher BMI and older age were associated with NAFLD in our study. |
| format | Article |
| id | doaj-art-a36101caba7b4924a7de216557bb2e84 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2021-01-01 |
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| spelling | doaj-art-a36101caba7b4924a7de216557bb2e842025-08-20T02:17:57ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01165e025228610.1371/journal.pone.0252286Evaluation of non-alcoholic fatty liver disease in patients with inflammatory bowel disease using controlled attenuation parameter technology: A Taiwanese retrospective cohort study.Hsu-Heng YenPei-Yuan SuSiou-Ping HuangLisha WuTsui-Chun HsuYa-Huei ZengYang-Yuan Chen<h4>Background/purpose</h4>An increased prevalence of non-alcoholic fatty liver disease (NAFLD) is observed in patients with inflammatory bowel disease (IBD) in Western countries. Both intestinal inflammation and metabolic factors contribute to the pathogenesis of IBD-associated NAFLD. The burden of NAFLD is not clear in the Asian population. This study aimed to evaluate the prevalence of NAFLD and liver fibrosis in a cohort of Taiwanese patients with IBD.<h4>Methods</h4>From January to December 2019, patients with IBD who underwent ultrasound examination were enrolled. Hepatic steatosis and fibrosis were measured with liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) using FibroScan. Patients with a history of excessive alcohol or recent steroid use were excluded. Univariate and multivariate analysis were performed.<h4>Results</h4>A total of 81 consecutive patients were enrolled and included in the analysis (45 with ulcerative colitis, 36 with Crohn's disease). The median age was 42 years old. The patients were classified in terms of body mass index as normal weight (54.3%), underweight (11.1%), overweight (28.4%), and obese (6.2%). The mean CAP increased to 162.22 dB/m in the underweight group, 210.86 dB/m in the normal weight group, 260.7 dB/m in the overweight group, and 274.0 dB/m in the obese group. NAFLD was observed in 29.6% of the patients, 1.2% of which had significant fibrosis. Increased body mass index (odds ratio [OR] 1.33, 95% confidence interval [CI] 1.1-1.62) and older age at IBD diagnosis (OR: 1.05, 95% CI 1-1.11) was found to be associated with the presence of NAFLD.<h4>Conclusion</h4>In this study, the prevalence of NAFLD was lower (29.6%) in IBD patients than in the Western population. Higher BMI and older age were associated with NAFLD in our study.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0252286&type=printable |
| spellingShingle | Hsu-Heng Yen Pei-Yuan Su Siou-Ping Huang Lisha Wu Tsui-Chun Hsu Ya-Huei Zeng Yang-Yuan Chen Evaluation of non-alcoholic fatty liver disease in patients with inflammatory bowel disease using controlled attenuation parameter technology: A Taiwanese retrospective cohort study. PLoS ONE |
| title | Evaluation of non-alcoholic fatty liver disease in patients with inflammatory bowel disease using controlled attenuation parameter technology: A Taiwanese retrospective cohort study. |
| title_full | Evaluation of non-alcoholic fatty liver disease in patients with inflammatory bowel disease using controlled attenuation parameter technology: A Taiwanese retrospective cohort study. |
| title_fullStr | Evaluation of non-alcoholic fatty liver disease in patients with inflammatory bowel disease using controlled attenuation parameter technology: A Taiwanese retrospective cohort study. |
| title_full_unstemmed | Evaluation of non-alcoholic fatty liver disease in patients with inflammatory bowel disease using controlled attenuation parameter technology: A Taiwanese retrospective cohort study. |
| title_short | Evaluation of non-alcoholic fatty liver disease in patients with inflammatory bowel disease using controlled attenuation parameter technology: A Taiwanese retrospective cohort study. |
| title_sort | evaluation of non alcoholic fatty liver disease in patients with inflammatory bowel disease using controlled attenuation parameter technology a taiwanese retrospective cohort study |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0252286&type=printable |
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