Strictosamide and mitraphylline inhibit cancer cell motility by suppressing epithelial-mesenchymal transition via integrin α4-mediated signaling

Strictosamide and mitraphylline inhibit cancer cell motility by suppressing epithelial-mesenchymal transition via integrin α4-mediated signaling

Abstract Epithelial-mesenchymal transition (EMT) is a critical process in cancer cell motility and metastasis. Monoterpene indole alkaloids (MIAs) have been widely investigated for biological activities, but rarely been explored for cell motility inhibition. This study aimed to discover natural prod...

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Bibliographic Details
Main Authors: Mücahit Varlı, Kyungha Lee, Tran The Bach, Tran Duc Binh, Hangun Kim, Kyo Bin Kang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Bioactivity-guided fractionation
Metastasis suppressor
Integrin Α4β1 agonist
Vallesiachotaman-type alkaloid
Spirocylic oxindole alkaloid
Online Access:https://doi.org/10.1038/s41598-025-04064-7
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