Invasive aspergillosis a complication severe respiratory viral infections (influenza and COVID-19)
Invasive aspergillosis is a life-threatening complication in patients with severe influenza and COVID-19 in intensive care units. Risk factors for the invasive aspergillosis development are transitory immunosuppression associated with severe influenza and COVID-19, as well as the use of glucocortico...
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2021-12-01
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| Series: | Журнал инфектологии |
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| Online Access: | https://journal.niidi.ru/jofin/article/view/1265 |
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| author | N. N. Klimko O. V. Shadrivova |
| author_facet | N. N. Klimko O. V. Shadrivova |
| author_sort | N. N. Klimko |
| collection | DOAJ |
| description | Invasive aspergillosis is a life-threatening complication in patients with severe influenza and COVID-19 in intensive care units. Risk factors for the invasive aspergillosis development are transitory immunosuppression associated with severe influenza and COVID-19, as well as the use of glucocorticosteroids and immunosuppressive therapy. In the presence of risk factors, suspected clinical and radiological signs of invasive aspergillosis, bronchoscopy and examination of material from the lower respiratory tract are necessary: test for galactomannan, microscopy with white calcofluor staining and inoculation on Sabouraud agar medium. Voriconazole or are recommended as first-line treatment for invasive aspergillosis in patients with severe influenza and COVID-19. Amphotericin B Liposomal, Amphotericin B Lipid Complex, and Caspofungin are the alternative options for the invasive aspergillosis treatment. Combination therapy is possible. It is necessary to control the underlying disease with eliminate or reduce the severity of risk factors. |
| format | Article |
| id | doaj-art-a35ba558de7f457694de32cf16cb3a55 |
| institution | Kabale University |
| issn | 2072-6732 |
| language | Russian |
| publishDate | 2021-12-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj-art-a35ba558de7f457694de32cf16cb3a552025-08-20T03:38:31ZrusJournal InfectologyЖурнал инфектологии2072-67322021-12-01134142410.22625/2072-6732-2021-13-4-14-24948Invasive aspergillosis a complication severe respiratory viral infections (influenza and COVID-19)N. N. Klimko0O. V. Shadrivova1North-Western State Medical University named after I.I. MechnikovNorth-Western State Medical University named after I.I. MechnikovInvasive aspergillosis is a life-threatening complication in patients with severe influenza and COVID-19 in intensive care units. Risk factors for the invasive aspergillosis development are transitory immunosuppression associated with severe influenza and COVID-19, as well as the use of glucocorticosteroids and immunosuppressive therapy. In the presence of risk factors, suspected clinical and radiological signs of invasive aspergillosis, bronchoscopy and examination of material from the lower respiratory tract are necessary: test for galactomannan, microscopy with white calcofluor staining and inoculation on Sabouraud agar medium. Voriconazole or are recommended as first-line treatment for invasive aspergillosis in patients with severe influenza and COVID-19. Amphotericin B Liposomal, Amphotericin B Lipid Complex, and Caspofungin are the alternative options for the invasive aspergillosis treatment. Combination therapy is possible. It is necessary to control the underlying disease with eliminate or reduce the severity of risk factors.https://journal.niidi.ru/jofin/article/view/1265invasive aspergillosisaspergillus spp.covid-19capa |
| spellingShingle | N. N. Klimko O. V. Shadrivova Invasive aspergillosis a complication severe respiratory viral infections (influenza and COVID-19) Журнал инфектологии invasive aspergillosis aspergillus spp. covid-19 capa |
| title | Invasive aspergillosis a complication severe respiratory viral infections (influenza and COVID-19) |
| title_full | Invasive aspergillosis a complication severe respiratory viral infections (influenza and COVID-19) |
| title_fullStr | Invasive aspergillosis a complication severe respiratory viral infections (influenza and COVID-19) |
| title_full_unstemmed | Invasive aspergillosis a complication severe respiratory viral infections (influenza and COVID-19) |
| title_short | Invasive aspergillosis a complication severe respiratory viral infections (influenza and COVID-19) |
| title_sort | invasive aspergillosis a complication severe respiratory viral infections influenza and covid 19 |
| topic | invasive aspergillosis aspergillus spp. covid-19 capa |
| url | https://journal.niidi.ru/jofin/article/view/1265 |
| work_keys_str_mv | AT nnklimko invasiveaspergillosisacomplicationsevererespiratoryviralinfectionsinfluenzaandcovid19 AT ovshadrivova invasiveaspergillosisacomplicationsevererespiratoryviralinfectionsinfluenzaandcovid19 |