Cytomegalovirus infection in immunocompetent pregnant women: clinical manifestations and management tactics
Objective: to analyze clinical manifestations, diagnostic and therapeutic approaches to management of pregnant women with cytomegalovirus infection for optimization of clinical and laboratory diagnostics and reduction of risks of congenital cytomegalovirus infection in the postnatal period.Materials...
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2022-07-01
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| Series: | Журнал инфектологии |
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| Online Access: | https://journal.niidi.ru/jofin/article/view/1356 |
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| author | N. V. Rogozina V. V. Vasil’ev N. S. Bezverhaja R. A. Ivanova G. M. Ushakova E. S. Romanova |
| author_facet | N. V. Rogozina V. V. Vasil’ev N. S. Bezverhaja R. A. Ivanova G. M. Ushakova E. S. Romanova |
| author_sort | N. V. Rogozina |
| collection | DOAJ |
| description | Objective: to analyze clinical manifestations, diagnostic and therapeutic approaches to management of pregnant women with cytomegalovirus infection for optimization of clinical and laboratory diagnostics and reduction of risks of congenital cytomegalovirus infection in the postnatal period.Materials and methods: in the article describe results a retrospective study the pregnancy course of 92 women who had 94 children with a confirmed congenital manifest form of cytomegalovirus infection. The inclusion criteria in main group were women aged 18-40 years and presence the results of examination for TORCH-syndrome in the first trimester of pregnancy, negative results for HIV. Markers of cytomegalovirus infection were determined by PCR (blood, vaginal secretions) and serologically (IgM, IgG to CMV-infection).Findings: the study showed that acute cytomegalovirus infection was documented during pregnancy in 18.4% of cases, and recrudescence of CMV-infection only in 33.6% of cases. Acute cytomegalovirus infection was asymptomatic in 35.3% of patients, the rest had nonspecific symptoms in the form of fatigue and headache, cholestasis was registered in 35.2% of cases, whereas with recrudescence of cytomegalovirus infection, catarrhal symptoms in the form of rhinitis and pharyngitis prevailed 42,8% cases, p<0,05. 15 people received therapy during pregnancy: 2 of them – antiviral (valgancyclovir), 11 – immunocorrective (interferon2alfa) and 2 – pathogenetic therapy (blood transfusion to the fetus for anemia). Based on the literature data and obtained by analyzing management tactics of the observed pregnant women, an algorithm for the management of pregnant women with cytomegalovirus infection was created.Conclusion: the study made it possible to substantiate algorithm of diagnosis and tactics management of cytomegalovirus infection in immunocompetent pregnant women and gave recommendations for obstetricians and gynecologists about alertness regarding cytomegalovirus infection. |
| format | Article |
| id | doaj-art-a35a6ae89526450db0aebc498fcbf7dd |
| institution | Kabale University |
| issn | 2072-6732 |
| language | Russian |
| publishDate | 2022-07-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj-art-a35a6ae89526450db0aebc498fcbf7dd2025-08-20T04:00:15ZrusJournal InfectologyЖурнал инфектологии2072-67322022-07-01142808610.22625/2072-6732-2022-14-2-80-86992Cytomegalovirus infection in immunocompetent pregnant women: clinical manifestations and management tacticsN. V. Rogozina0V. V. Vasil’ev1N. S. Bezverhaja2R. A. Ivanova3G. M. Ushakova4E. S. Romanova5Pediatric Research and Clinical Center for Infectious Diseases; Saint-Petersburg State Pediatric Medical UniversityPediatric Research and Clinical Center for Infectious Diseases; North-Western State Medical University named after I.I. MechnikovPediatric Research and Clinical Center for Infectious DiseasesPediatric Research and Clinical Center for Infectious Diseases; First Saint-Petersburg State Medical University named after academician I.P. PavlovPediatric Research and Clinical Center for Infectious DiseasesNorth-Western State Medical University named after I.I. MechnikovObjective: to analyze clinical manifestations, diagnostic and therapeutic approaches to management of pregnant women with cytomegalovirus infection for optimization of clinical and laboratory diagnostics and reduction of risks of congenital cytomegalovirus infection in the postnatal period.Materials and methods: in the article describe results a retrospective study the pregnancy course of 92 women who had 94 children with a confirmed congenital manifest form of cytomegalovirus infection. The inclusion criteria in main group were women aged 18-40 years and presence the results of examination for TORCH-syndrome in the first trimester of pregnancy, negative results for HIV. Markers of cytomegalovirus infection were determined by PCR (blood, vaginal secretions) and serologically (IgM, IgG to CMV-infection).Findings: the study showed that acute cytomegalovirus infection was documented during pregnancy in 18.4% of cases, and recrudescence of CMV-infection only in 33.6% of cases. Acute cytomegalovirus infection was asymptomatic in 35.3% of patients, the rest had nonspecific symptoms in the form of fatigue and headache, cholestasis was registered in 35.2% of cases, whereas with recrudescence of cytomegalovirus infection, catarrhal symptoms in the form of rhinitis and pharyngitis prevailed 42,8% cases, p<0,05. 15 people received therapy during pregnancy: 2 of them – antiviral (valgancyclovir), 11 – immunocorrective (interferon2alfa) and 2 – pathogenetic therapy (blood transfusion to the fetus for anemia). Based on the literature data and obtained by analyzing management tactics of the observed pregnant women, an algorithm for the management of pregnant women with cytomegalovirus infection was created.Conclusion: the study made it possible to substantiate algorithm of diagnosis and tactics management of cytomegalovirus infection in immunocompetent pregnant women and gave recommendations for obstetricians and gynecologists about alertness regarding cytomegalovirus infection.https://journal.niidi.ru/jofin/article/view/1356cytomegaloviruspregnant womendiagnosistreatment |
| spellingShingle | N. V. Rogozina V. V. Vasil’ev N. S. Bezverhaja R. A. Ivanova G. M. Ushakova E. S. Romanova Cytomegalovirus infection in immunocompetent pregnant women: clinical manifestations and management tactics Журнал инфектологии cytomegalovirus pregnant women diagnosis treatment |
| title | Cytomegalovirus infection in immunocompetent pregnant women: clinical manifestations and management tactics |
| title_full | Cytomegalovirus infection in immunocompetent pregnant women: clinical manifestations and management tactics |
| title_fullStr | Cytomegalovirus infection in immunocompetent pregnant women: clinical manifestations and management tactics |
| title_full_unstemmed | Cytomegalovirus infection in immunocompetent pregnant women: clinical manifestations and management tactics |
| title_short | Cytomegalovirus infection in immunocompetent pregnant women: clinical manifestations and management tactics |
| title_sort | cytomegalovirus infection in immunocompetent pregnant women clinical manifestations and management tactics |
| topic | cytomegalovirus pregnant women diagnosis treatment |
| url | https://journal.niidi.ru/jofin/article/view/1356 |
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