Correlation of TSHR and CTLA-4 Single Nucleotide Polymorphisms with Graves Disease
This study was designed to explore the association between Graves disease (GD) and thyroid-stimulating hormone receptor (TSHR) and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) single nucleotide polymorphisms (SNPs). We studied a total of 1217 subjects from a Han population in northern Anhui...
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| Format: | Article |
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Wiley
2019-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2019/6982623 |
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| author | Weihua Sun Xiaomei Zhang Jing Wu Wendi Zhao Shuangxia Zhao Minglong Li |
| author_facet | Weihua Sun Xiaomei Zhang Jing Wu Wendi Zhao Shuangxia Zhao Minglong Li |
| author_sort | Weihua Sun |
| collection | DOAJ |
| description | This study was designed to explore the association between Graves disease (GD) and thyroid-stimulating hormone receptor (TSHR) and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) single nucleotide polymorphisms (SNPs). We studied a total of 1217 subjects from a Han population in northern Anhui province in China. Six SNPs within TSHR (rs179247, rs12101261, rs2284722, rs4903964, rs2300525, and rs17111394) and four SNPs within CTLA-4 (rs10197319, rs231726, rs231804, and rs1024161) were genotyped via a Taqman probe technique using a Fluidigm EP1 platform. The TSHR alleles rs179247-G, rs12101261-C, and rs4903964-G were negatively correlated with GD, whereas the rs2284722-A and rs17111394-C alleles were positively correlated with GD. Analyzing TSHR SNPs at rs179247, rs2284722, rs12101261, and rs4903964 yielded 8 different haplotypes. There were positive correlations between GD risk and the haplotypes AGTA and AATA (OR=1.27, 95%CI=1.07‐1.50, P=0.005; OR=1.45, 95%CI=1.21‐1.75, P<0.001, respectively). There were negative correlations between GD risk and the haplotype GGCG (OR=0.56, 95%CI=0.46‐0.67, P<0.001). With respect to haplotypes based on SNPs at the TSHR rs2300525 and rs17111394 loci, the CC haplotype was positively correlated with GD risk (OR=1.32, 95%CI=1.08‐1.60, P=0.006). Analyzing CTLA-4 SNPs at rs231804, rs1024161, and rs231726 yielded four haplotypes, of which AAA was positively correlated with GD risk (OR=1.21, 95%CI=1.02‐1.43, P=0.029). Polymorphisms at rs179247, rs12101261, rs2284722, rs4903964, and rs17111394 were associated with GD susceptibility. Haplotypes of both TSHR and CTLA-4 were additionally related to GD risk. |
| format | Article |
| id | doaj-art-a358f21cfe414104bce3192003e40b77 |
| institution | OA Journals |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2019-01-01 |
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| spelling | doaj-art-a358f21cfe414104bce3192003e40b772025-08-20T02:20:32ZengWileyInternational Journal of Genomics2314-436X2314-43782019-01-01201910.1155/2019/69826236982623Correlation of TSHR and CTLA-4 Single Nucleotide Polymorphisms with Graves DiseaseWeihua Sun0Xiaomei Zhang1Jing Wu2Wendi Zhao3Shuangxia Zhao4Minglong Li5Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250000 Shandong Province, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233000 Anhui Province, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233000 Anhui Province, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233000 Anhui Province, ChinaThe Core Laboratory in Medical Center of Clinical Research, Department of Endocrinology, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University (SJTU) School of Medicine, Shanghai 200011, ChinaDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250000 Shandong Province, ChinaThis study was designed to explore the association between Graves disease (GD) and thyroid-stimulating hormone receptor (TSHR) and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) single nucleotide polymorphisms (SNPs). We studied a total of 1217 subjects from a Han population in northern Anhui province in China. Six SNPs within TSHR (rs179247, rs12101261, rs2284722, rs4903964, rs2300525, and rs17111394) and four SNPs within CTLA-4 (rs10197319, rs231726, rs231804, and rs1024161) were genotyped via a Taqman probe technique using a Fluidigm EP1 platform. The TSHR alleles rs179247-G, rs12101261-C, and rs4903964-G were negatively correlated with GD, whereas the rs2284722-A and rs17111394-C alleles were positively correlated with GD. Analyzing TSHR SNPs at rs179247, rs2284722, rs12101261, and rs4903964 yielded 8 different haplotypes. There were positive correlations between GD risk and the haplotypes AGTA and AATA (OR=1.27, 95%CI=1.07‐1.50, P=0.005; OR=1.45, 95%CI=1.21‐1.75, P<0.001, respectively). There were negative correlations between GD risk and the haplotype GGCG (OR=0.56, 95%CI=0.46‐0.67, P<0.001). With respect to haplotypes based on SNPs at the TSHR rs2300525 and rs17111394 loci, the CC haplotype was positively correlated with GD risk (OR=1.32, 95%CI=1.08‐1.60, P=0.006). Analyzing CTLA-4 SNPs at rs231804, rs1024161, and rs231726 yielded four haplotypes, of which AAA was positively correlated with GD risk (OR=1.21, 95%CI=1.02‐1.43, P=0.029). Polymorphisms at rs179247, rs12101261, rs2284722, rs4903964, and rs17111394 were associated with GD susceptibility. Haplotypes of both TSHR and CTLA-4 were additionally related to GD risk.http://dx.doi.org/10.1155/2019/6982623 |
| spellingShingle | Weihua Sun Xiaomei Zhang Jing Wu Wendi Zhao Shuangxia Zhao Minglong Li Correlation of TSHR and CTLA-4 Single Nucleotide Polymorphisms with Graves Disease International Journal of Genomics |
| title | Correlation of TSHR and CTLA-4 Single Nucleotide Polymorphisms with Graves Disease |
| title_full | Correlation of TSHR and CTLA-4 Single Nucleotide Polymorphisms with Graves Disease |
| title_fullStr | Correlation of TSHR and CTLA-4 Single Nucleotide Polymorphisms with Graves Disease |
| title_full_unstemmed | Correlation of TSHR and CTLA-4 Single Nucleotide Polymorphisms with Graves Disease |
| title_short | Correlation of TSHR and CTLA-4 Single Nucleotide Polymorphisms with Graves Disease |
| title_sort | correlation of tshr and ctla 4 single nucleotide polymorphisms with graves disease |
| url | http://dx.doi.org/10.1155/2019/6982623 |
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