Cohort profile: Copenhagen Hospital Biobank - Cardiovascular Disease Cohort (CHB-CVDC): Construction of a large-scale genetic cohort to facilitate a better understanding of heart diseases
Purpose The aim of Copenhagen Hospital Biobank-Cardiovascular Disease Cohort (CHB-CVDC) is to establish a cohort that can accelerate our understanding of CVD initiation and progression by jointly studying genetics, diagnoses, treatments and risk factors.Participants The CHB-CVDC is a large genomic c...
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BMJ Publishing Group
2021-12-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/11/12/e049709.full |
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| author | Christian Torp-Pedersen Lars Køber Karina Banasik Christian Erikstrup David Westergaard Mette Nyegaard Erik Sørensen Søren Brunak Henrik Ullum Kari Stefansson Henning Bundgaard Unnur Thorsteinsdottir Ruth Frikke-Schmidt Hreinn Stefánsson Sisse R Ostrowski Ina H Laursen Amalie D Haue Oscar Petersen Peter C Holm Hilma Holm Lise W Thørner Margit A H Larsen Michael Schwinn Arnaldur Gylfason Florian Zink G Bragi Walters Asmundur Oddsson Guðmar Þorleifsson Gisli Másson Daniel Gudbjartsson Ole B Pedersen |
| author_facet | Christian Torp-Pedersen Lars Køber Karina Banasik Christian Erikstrup David Westergaard Mette Nyegaard Erik Sørensen Søren Brunak Henrik Ullum Kari Stefansson Henning Bundgaard Unnur Thorsteinsdottir Ruth Frikke-Schmidt Hreinn Stefánsson Sisse R Ostrowski Ina H Laursen Amalie D Haue Oscar Petersen Peter C Holm Hilma Holm Lise W Thørner Margit A H Larsen Michael Schwinn Arnaldur Gylfason Florian Zink G Bragi Walters Asmundur Oddsson Guðmar Þorleifsson Gisli Másson Daniel Gudbjartsson Ole B Pedersen |
| author_sort | Christian Torp-Pedersen |
| collection | DOAJ |
| description | Purpose The aim of Copenhagen Hospital Biobank-Cardiovascular Disease Cohort (CHB-CVDC) is to establish a cohort that can accelerate our understanding of CVD initiation and progression by jointly studying genetics, diagnoses, treatments and risk factors.Participants The CHB-CVDC is a large genomic cohort of patients with CVD. CHB-CVDC currently includes 96 308 patients. The cohort is part of CHB initiated in 2009 in the Capital Region of Denmark. CHB is continuously growing with ~40 000 samples/year. Patients in CHB were included in CHB-CVDC if they were above 18 years of age and assigned at least one cardiovascular diagnosis. Additionally, up-to 110 000 blood donors can be analysed jointly with CHB-CVDC. Linkage with the Danish National Health Registries, Electronic Patient Records, and Clinical Quality Databases allow up-to 41 years of medical history. All individuals are genotyped using the Infinium Global Screening Array from Illumina and imputed using a reference panel consisting of whole-genome sequence data from 8429 Danes along with 7146 samples from North-Western Europe. Currently, 39 539 of the patients are deceased.Findings to date Here, we demonstrate the utility of the cohort by showing concordant effects between known variants and selected CVDs, that is, >93% concordance for coronary artery disease, atrial fibrillation, heart failure and cholesterol measurements and 85% concordance for hypertension. Furthermore, we evaluated multiple study designs and the validity of using Danish blood donors as part of CHB-CVDC. Lastly, CHB-CVDC has already made major contributions to studies of sick sinus syndrome and the role of phytosterols in development of atherosclerosis.Future plans In addition to genetics, electronic patient records, national socioeconomic and health registries extensively characterise each patient in CHB-CVDC and provides a promising framework for improved understanding of risk and protective variants. We aim to include other measurable biomarkers for example, proteins in CHB-CVDC making it a platform for multiomics cardiovascular studies. |
| format | Article |
| id | doaj-art-a34d0f1752f84b5fada1b74199daa31c |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-a34d0f1752f84b5fada1b74199daa31c2025-08-20T02:20:38ZengBMJ Publishing GroupBMJ Open2044-60552021-12-01111210.1136/bmjopen-2021-049709Cohort profile: Copenhagen Hospital Biobank - Cardiovascular Disease Cohort (CHB-CVDC): Construction of a large-scale genetic cohort to facilitate a better understanding of heart diseasesChristian Torp-Pedersen0Lars Køber1Karina Banasik2Christian Erikstrup3David Westergaard4Mette Nyegaard5Erik Sørensen6Søren Brunak7Henrik Ullum8Kari Stefansson9Henning Bundgaard10Unnur Thorsteinsdottir11Ruth Frikke-Schmidt12Hreinn Stefánsson13Sisse R Ostrowski14Ina H Laursen15Amalie D Haue16Oscar Petersen17Peter C Holm18Hilma Holm19Lise W Thørner20Margit A H Larsen21Michael Schwinn22Arnaldur Gylfason23Florian Zink24G Bragi Walters25Asmundur Oddsson26Guðmar Þorleifsson27Gisli Másson28Daniel Gudbjartsson29Ole B Pedersen30Cardiology, North Zealand Hospital, Hilleroed, DenmarkDepartment of Cardiology, Rigshospitalet, Copenhagen, DenmarkNovo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, DenmarkDepartment of Clinical Immunology, Aarhus University Hospital, Aarhus, DenmarkNovo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, DenmarkHealth Science and Technology, Aalborg Universitet, Gistrup, DenmarkDepartment of Clinical Immunology, Section 2034, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark3 Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark13 Statens Serum Institut, Copenhagen, Denmark2 deCODE genetics/Amgen, Reykjavik, IcelandDepartment of Cardiology, Rigshospitalet, Copenhagen, DenmarkdeCODE genetics, Reykjavik, IcelandDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkdeCODE genetics, Reykjavik, IcelandDepartment of Clinical Immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, DenmarkDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, DenmarkNovo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, DenmarkDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, DenmarkNovo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, DenmarkdeCODE genetics, Reykjavik, IcelandDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, DenmarkDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, DenmarkDepartment of Clinical Immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, DenmarkdeCODE genetics, Reykjavik, IcelanddeCODE genetics, Reykjavik, IcelanddeCODE genetics, Reykjavik, IcelanddeCODE genetics, Reykjavik, IcelanddeCODE genetics, Reykjavik, IcelanddeCODE genetics, Reykjavik, IcelanddeCODE genetics, Reykjavik, IcelandDepartment of Clinical Immunology, Zealand University Hospital Køge, Køge, DenmarkPurpose The aim of Copenhagen Hospital Biobank-Cardiovascular Disease Cohort (CHB-CVDC) is to establish a cohort that can accelerate our understanding of CVD initiation and progression by jointly studying genetics, diagnoses, treatments and risk factors.Participants The CHB-CVDC is a large genomic cohort of patients with CVD. CHB-CVDC currently includes 96 308 patients. The cohort is part of CHB initiated in 2009 in the Capital Region of Denmark. CHB is continuously growing with ~40 000 samples/year. Patients in CHB were included in CHB-CVDC if they were above 18 years of age and assigned at least one cardiovascular diagnosis. Additionally, up-to 110 000 blood donors can be analysed jointly with CHB-CVDC. Linkage with the Danish National Health Registries, Electronic Patient Records, and Clinical Quality Databases allow up-to 41 years of medical history. All individuals are genotyped using the Infinium Global Screening Array from Illumina and imputed using a reference panel consisting of whole-genome sequence data from 8429 Danes along with 7146 samples from North-Western Europe. Currently, 39 539 of the patients are deceased.Findings to date Here, we demonstrate the utility of the cohort by showing concordant effects between known variants and selected CVDs, that is, >93% concordance for coronary artery disease, atrial fibrillation, heart failure and cholesterol measurements and 85% concordance for hypertension. Furthermore, we evaluated multiple study designs and the validity of using Danish blood donors as part of CHB-CVDC. Lastly, CHB-CVDC has already made major contributions to studies of sick sinus syndrome and the role of phytosterols in development of atherosclerosis.Future plans In addition to genetics, electronic patient records, national socioeconomic and health registries extensively characterise each patient in CHB-CVDC and provides a promising framework for improved understanding of risk and protective variants. We aim to include other measurable biomarkers for example, proteins in CHB-CVDC making it a platform for multiomics cardiovascular studies.https://bmjopen.bmj.com/content/11/12/e049709.full |
| spellingShingle | Christian Torp-Pedersen Lars Køber Karina Banasik Christian Erikstrup David Westergaard Mette Nyegaard Erik Sørensen Søren Brunak Henrik Ullum Kari Stefansson Henning Bundgaard Unnur Thorsteinsdottir Ruth Frikke-Schmidt Hreinn Stefánsson Sisse R Ostrowski Ina H Laursen Amalie D Haue Oscar Petersen Peter C Holm Hilma Holm Lise W Thørner Margit A H Larsen Michael Schwinn Arnaldur Gylfason Florian Zink G Bragi Walters Asmundur Oddsson Guðmar Þorleifsson Gisli Másson Daniel Gudbjartsson Ole B Pedersen Cohort profile: Copenhagen Hospital Biobank - Cardiovascular Disease Cohort (CHB-CVDC): Construction of a large-scale genetic cohort to facilitate a better understanding of heart diseases BMJ Open |
| title | Cohort profile: Copenhagen Hospital Biobank - Cardiovascular Disease Cohort (CHB-CVDC): Construction of a large-scale genetic cohort to facilitate a better understanding of heart diseases |
| title_full | Cohort profile: Copenhagen Hospital Biobank - Cardiovascular Disease Cohort (CHB-CVDC): Construction of a large-scale genetic cohort to facilitate a better understanding of heart diseases |
| title_fullStr | Cohort profile: Copenhagen Hospital Biobank - Cardiovascular Disease Cohort (CHB-CVDC): Construction of a large-scale genetic cohort to facilitate a better understanding of heart diseases |
| title_full_unstemmed | Cohort profile: Copenhagen Hospital Biobank - Cardiovascular Disease Cohort (CHB-CVDC): Construction of a large-scale genetic cohort to facilitate a better understanding of heart diseases |
| title_short | Cohort profile: Copenhagen Hospital Biobank - Cardiovascular Disease Cohort (CHB-CVDC): Construction of a large-scale genetic cohort to facilitate a better understanding of heart diseases |
| title_sort | cohort profile copenhagen hospital biobank cardiovascular disease cohort chb cvdc construction of a large scale genetic cohort to facilitate a better understanding of heart diseases |
| url | https://bmjopen.bmj.com/content/11/12/e049709.full |
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