Astaxanthin prevents bone loss in osteoporotic rats with palmitic acid through suppressing oxidative stress
Objectives The study aimed to assess the role of Astaxanthin (ATX) in palmitic acid(PA) -induced bone loss in Ovariectomized(OVX) rats.Methods In the OVX rat model, we observed that PA affects bone metabolism and accelerates bone loss. Additionally, treatment with ATX was able to suppress the delete...
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Taylor & Francis Group
2024-12-01
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| Series: | Redox Report |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/13510002.2024.2333096 |
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| author | Zhou-Shan Tao Xing-Jing Wu Min Yang Cai-Liang Shen |
| author_facet | Zhou-Shan Tao Xing-Jing Wu Min Yang Cai-Liang Shen |
| author_sort | Zhou-Shan Tao |
| collection | DOAJ |
| description | Objectives The study aimed to assess the role of Astaxanthin (ATX) in palmitic acid(PA) -induced bone loss in Ovariectomized(OVX) rats.Methods In the OVX rat model, we observed that PA affects bone metabolism and accelerates bone loss. Additionally, treatment with ATX was able to suppress the deleterious effects of PA and a simultaneous decrease in serum MDA levels and an increase in SOD was observed.Results In addition, rats treated with ATX were observed to have significantly increased bone mass and elevated activity of SIRT1 and SOD2 in bone tissue. When MC3T3-E1 and RAW264.7 cells induced osteoblast and osteoclast differentiation, the ATX intervention was able to significantly restore the restriction of osteogenic differentiation and the up-regulation of osteoclast differentiation with PA therapy. Furthermore, we confirm that PA damage to cells is caused by increased oxidative stress, and that ATX can target and modulate the activity of SIRT1 to regulate the levels of oxidative stress in cells.Conclusion Summarizing, ATX may inhibit PA-induced bone loss through its antioxidant properties via the SIRT1 signaling pathway. |
| format | Article |
| id | doaj-art-a33e8cfc5a47434486aa12a385aef888 |
| institution | OA Journals |
| issn | 1351-0002 1743-2928 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Redox Report |
| spelling | doaj-art-a33e8cfc5a47434486aa12a385aef8882025-08-20T02:21:07ZengTaylor & Francis GroupRedox Report1351-00021743-29282024-12-0129110.1080/13510002.2024.2333096Astaxanthin prevents bone loss in osteoporotic rats with palmitic acid through suppressing oxidative stressZhou-Shan Tao0Xing-Jing Wu1Min Yang2Cai-Liang Shen3Department of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, No. 2, Zhe Shan Xi Road, Wuhu, Anhui, People’s Republic of ChinaDepartment of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, No. 2, Zhe Shan Xi Road, Wuhu, Anhui, People’s Republic of ChinaDepartment of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, No. 2, Zhe Shan Xi Road, Wuhu, Anhui, People’s Republic of ChinaDepartment of Spinal Surgery, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Shushan District, Hefei, Anhui, People’s Republic of ChinaObjectives The study aimed to assess the role of Astaxanthin (ATX) in palmitic acid(PA) -induced bone loss in Ovariectomized(OVX) rats.Methods In the OVX rat model, we observed that PA affects bone metabolism and accelerates bone loss. Additionally, treatment with ATX was able to suppress the deleterious effects of PA and a simultaneous decrease in serum MDA levels and an increase in SOD was observed.Results In addition, rats treated with ATX were observed to have significantly increased bone mass and elevated activity of SIRT1 and SOD2 in bone tissue. When MC3T3-E1 and RAW264.7 cells induced osteoblast and osteoclast differentiation, the ATX intervention was able to significantly restore the restriction of osteogenic differentiation and the up-regulation of osteoclast differentiation with PA therapy. Furthermore, we confirm that PA damage to cells is caused by increased oxidative stress, and that ATX can target and modulate the activity of SIRT1 to regulate the levels of oxidative stress in cells.Conclusion Summarizing, ATX may inhibit PA-induced bone loss through its antioxidant properties via the SIRT1 signaling pathway.https://www.tandfonline.com/doi/10.1080/13510002.2024.2333096AstaxanthinOsteoporosisPalmitic acidOxidative stressBone metabolism |
| spellingShingle | Zhou-Shan Tao Xing-Jing Wu Min Yang Cai-Liang Shen Astaxanthin prevents bone loss in osteoporotic rats with palmitic acid through suppressing oxidative stress Redox Report Astaxanthin Osteoporosis Palmitic acid Oxidative stress Bone metabolism |
| title | Astaxanthin prevents bone loss in osteoporotic rats with palmitic acid through suppressing oxidative stress |
| title_full | Astaxanthin prevents bone loss in osteoporotic rats with palmitic acid through suppressing oxidative stress |
| title_fullStr | Astaxanthin prevents bone loss in osteoporotic rats with palmitic acid through suppressing oxidative stress |
| title_full_unstemmed | Astaxanthin prevents bone loss in osteoporotic rats with palmitic acid through suppressing oxidative stress |
| title_short | Astaxanthin prevents bone loss in osteoporotic rats with palmitic acid through suppressing oxidative stress |
| title_sort | astaxanthin prevents bone loss in osteoporotic rats with palmitic acid through suppressing oxidative stress |
| topic | Astaxanthin Osteoporosis Palmitic acid Oxidative stress Bone metabolism |
| url | https://www.tandfonline.com/doi/10.1080/13510002.2024.2333096 |
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