Melanoma Arising after Imiquimod Use
Imiquimod belongs to the class of 1H-imidazo-[4,5-c]quinolones—drugs originally developed as nucleoside analogues with the aim of finding new potential antiviral agents (Harrison et al., 1988). Indeed, Imiquimod was first released as treatment for genital warts before its actions against skin cancer...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2014/267535 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849694698231300096 |
|---|---|
| author | Sharad P. Paul |
| author_facet | Sharad P. Paul |
| author_sort | Sharad P. Paul |
| collection | DOAJ |
| description | Imiquimod belongs to the class of 1H-imidazo-[4,5-c]quinolones—drugs originally developed as nucleoside analogues with the aim of finding new potential antiviral agents (Harrison et al., 1988). Indeed, Imiquimod was first released as treatment for genital warts before its actions against skin cancer were studied. Imiquimod is a relatively small sized molecule (Mr = 240.3) and is hydrophobic, allowing it to penetrate the skin epidermal barrier and therefore making it suitable for topical formulations (Gerster et al., 2005). Imiquimod has shown itself effective against skin cancers and precancerous lesions, especially basal cell cancers and actinic keratosis (Salasche et al., 2002, Beutner et al., 1999). There have been reports of Imiquimod being used as topical treatment against cutaneous metastases of melanoma and some authors have reported its use as first-line therapy against melanoma in situ (Smyth et al., 2011, Gagnon, 2011). We report a case of an invasive malignant melanoma arising de novo at the specific site of application of Imiquimod (Aldara cream 5%) for a biopsy-proven superficial BCC. Therefore while Imiquimod has added to our topical armamentarium against skin cancer, care must be exercised in prescribing this treatment and it is especially important to follow up patients regularly. |
| format | Article |
| id | doaj-art-a33bf47a02904ff39a3f1a126e0f6daf |
| institution | DOAJ |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-a33bf47a02904ff39a3f1a126e0f6daf2025-08-20T03:19:59ZengWileyCase Reports in Medicine1687-96271687-96352014-01-01201410.1155/2014/267535267535Melanoma Arising after Imiquimod UseSharad P. Paul0University of Auckland, Auckland 1010, New ZealandImiquimod belongs to the class of 1H-imidazo-[4,5-c]quinolones—drugs originally developed as nucleoside analogues with the aim of finding new potential antiviral agents (Harrison et al., 1988). Indeed, Imiquimod was first released as treatment for genital warts before its actions against skin cancer were studied. Imiquimod is a relatively small sized molecule (Mr = 240.3) and is hydrophobic, allowing it to penetrate the skin epidermal barrier and therefore making it suitable for topical formulations (Gerster et al., 2005). Imiquimod has shown itself effective against skin cancers and precancerous lesions, especially basal cell cancers and actinic keratosis (Salasche et al., 2002, Beutner et al., 1999). There have been reports of Imiquimod being used as topical treatment against cutaneous metastases of melanoma and some authors have reported its use as first-line therapy against melanoma in situ (Smyth et al., 2011, Gagnon, 2011). We report a case of an invasive malignant melanoma arising de novo at the specific site of application of Imiquimod (Aldara cream 5%) for a biopsy-proven superficial BCC. Therefore while Imiquimod has added to our topical armamentarium against skin cancer, care must be exercised in prescribing this treatment and it is especially important to follow up patients regularly.http://dx.doi.org/10.1155/2014/267535 |
| spellingShingle | Sharad P. Paul Melanoma Arising after Imiquimod Use Case Reports in Medicine |
| title | Melanoma Arising after Imiquimod Use |
| title_full | Melanoma Arising after Imiquimod Use |
| title_fullStr | Melanoma Arising after Imiquimod Use |
| title_full_unstemmed | Melanoma Arising after Imiquimod Use |
| title_short | Melanoma Arising after Imiquimod Use |
| title_sort | melanoma arising after imiquimod use |
| url | http://dx.doi.org/10.1155/2014/267535 |
| work_keys_str_mv | AT sharadppaul melanomaarisingafterimiquimoduse |