Invasive Squamous Cell Carcinoma of Anterior Mediastinum of Unknown Primary Site

The most common lesions in the anterior mediastinum are thymomas, lymphomas, teratomas, and thyroid masses. Squamous cell carcinoma of anterior mediastinum is most commonly due to thymic carcinoma. We present an unusual case of a patient presenting with anterior mediastinal mass that was later found...

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Main Authors: Bibek Koirala, Min Zhang, Ali Akalin
Format: Article
Language:English
Published: American College of Physicians 2023-09-01
Series:Annals of Internal Medicine: Clinical Cases
Online Access:https://www.acpjournals.org/doi/10.7326/aimcc.2023.0111
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author Bibek Koirala
Min Zhang
Ali Akalin
author_facet Bibek Koirala
Min Zhang
Ali Akalin
author_sort Bibek Koirala
collection DOAJ
description The most common lesions in the anterior mediastinum are thymomas, lymphomas, teratomas, and thyroid masses. Squamous cell carcinoma of anterior mediastinum is most commonly due to thymic carcinoma. We present an unusual case of a patient presenting with anterior mediastinal mass that was later found to be biopsy-proven invasive squamous cell carcinoma of unknown primary site based on the available imaging studies. We also review the broad differential diagnoses, clinical presentation, and diagnostic work-up of anterior mediastinal mass, especially the one with no clear primary site.
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series Annals of Internal Medicine: Clinical Cases
spelling doaj-art-a33300c7af49495ebea6ab67b3748a132025-08-20T02:11:46ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642023-09-012910.7326/aimcc.2023.0111Invasive Squamous Cell Carcinoma of Anterior Mediastinum of Unknown Primary SiteBibek Koirala0Min Zhang1Ali Akalin21UMass Memorial Medical Center, Worcester, Massachusetts1UMass Memorial Medical Center, Worcester, Massachusetts1UMass Memorial Medical Center, Worcester, MassachusettsThe most common lesions in the anterior mediastinum are thymomas, lymphomas, teratomas, and thyroid masses. Squamous cell carcinoma of anterior mediastinum is most commonly due to thymic carcinoma. We present an unusual case of a patient presenting with anterior mediastinal mass that was later found to be biopsy-proven invasive squamous cell carcinoma of unknown primary site based on the available imaging studies. We also review the broad differential diagnoses, clinical presentation, and diagnostic work-up of anterior mediastinal mass, especially the one with no clear primary site.https://www.acpjournals.org/doi/10.7326/aimcc.2023.0111
spellingShingle Bibek Koirala
Min Zhang
Ali Akalin
Invasive Squamous Cell Carcinoma of Anterior Mediastinum of Unknown Primary Site
Annals of Internal Medicine: Clinical Cases
title Invasive Squamous Cell Carcinoma of Anterior Mediastinum of Unknown Primary Site
title_full Invasive Squamous Cell Carcinoma of Anterior Mediastinum of Unknown Primary Site
title_fullStr Invasive Squamous Cell Carcinoma of Anterior Mediastinum of Unknown Primary Site
title_full_unstemmed Invasive Squamous Cell Carcinoma of Anterior Mediastinum of Unknown Primary Site
title_short Invasive Squamous Cell Carcinoma of Anterior Mediastinum of Unknown Primary Site
title_sort invasive squamous cell carcinoma of anterior mediastinum of unknown primary site
url https://www.acpjournals.org/doi/10.7326/aimcc.2023.0111
work_keys_str_mv AT bibekkoirala invasivesquamouscellcarcinomaofanteriormediastinumofunknownprimarysite
AT minzhang invasivesquamouscellcarcinomaofanteriormediastinumofunknownprimarysite
AT aliakalin invasivesquamouscellcarcinomaofanteriormediastinumofunknownprimarysite