Hypoglycemic and Hypolipidemic Potential of Ginger-Thyme Combined Extract in Sucrose-Induced Hyperglycemic Rates
The current study was designed to investigate the in vivo action of ginger-thyme combined crude extract on hyperglycemia and obesity-related measurements in sucrose-induced chronic hyperglycemia experimental model in albino male rats. Twenty-five male albino rats were divided into five groups (n = 5...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Erbil Polytechnic University
2021-12-01
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| Series: | Polytechnic Journal |
| Subjects: | |
| Online Access: | https://polytechnic-journal.epu.edu.iq/home/vol11/iss2/17 |
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| Summary: | The current study was designed to investigate the in vivo action of ginger-thyme combined crude
extract on hyperglycemia and obesity-related measurements in sucrose-induced chronic hyperglycemia
experimental model in albino male rats. Twenty-five male albino rats were divided into five groups
(n = 5 for each); the first group was regarded as control, while the second group was the model
which consists of high sucrose fed (50% sucrose in water) and other three groups were rats which
treated with three different doses of ginger-thyme combination extract (125 mg/kg, 250 mg/kg, and
500 mg/kg). Animals were received one dose/day using oral stomach gavage for 8 weeks. Blood
samples were collected for quantitative determination of glucose levels, oral glucose tolerance tests,
serum insulin, glycohemoglobin (hemoglobin A1c), and various other laboratory analyses such as lipid
profiles, in addition to water intake and body weight throughout the study. Significant reduction of
blood glucose levels was occurred in all plant combination extract doses compared to sucrose diet rat
model group, especially the medium dose 250 mg/kg which found to be the best one. Serum insulin
was reduced in the model group compared to control and treatment groups, while it was increased in
all extract treating groups compared to the model group. |
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| ISSN: | 2707-7799 |