Regulation of brain metabolism by peripheral nutritional signals: the role of blood-brain barrier in health and disease
The blood-brain barrier (BBB) prevents unregulated substance exchange between the central nervous system and the blood, while providing highly regulated transport of nutrients and tonic factors essential to brain metabolism. A group of carriers, transporters, and receptors is utilized by endothelial...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2022-03-01
|
| Series: | Journal of Holistic Integrative Pharmacy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2707368823000614 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846170104627200000 |
|---|---|
| author | Dianhui ZHANG Zhenni GUO Yi YANG Junlei CHANG |
| author_facet | Dianhui ZHANG Zhenni GUO Yi YANG Junlei CHANG |
| author_sort | Dianhui ZHANG |
| collection | DOAJ |
| description | The blood-brain barrier (BBB) prevents unregulated substance exchange between the central nervous system and the blood, while providing highly regulated transport of nutrients and tonic factors essential to brain metabolism. A group of carriers, transporters, and receptors is utilized by endothelial cells of the BBB to aid the influx and efflux of nutrients and metabolic wastes, and their function is subject to changes during metabolic disorders such as diabetes mellitus and obesity. This regulated barrier function of BBB is essential for maintaining the normal metabolism of the brain and transduction of metabolic signals from the periphery. As such, disruption of the BBB nutrient/hormone transport system has been proposed to be major contributors of many neurological diseases. |
| format | Article |
| id | doaj-art-a32a4d3db453474e8b5d4c4b4f6650cb |
| institution | Kabale University |
| issn | 2707-3688 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Journal of Holistic Integrative Pharmacy |
| spelling | doaj-art-a32a4d3db453474e8b5d4c4b4f6650cb2024-11-12T05:21:36ZengKeAi Communications Co., Ltd.Journal of Holistic Integrative Pharmacy2707-36882022-03-0131717Regulation of brain metabolism by peripheral nutritional signals: the role of blood-brain barrier in health and diseaseDianhui ZHANG0Zhenni GUO1Yi YANG2Junlei CHANG3Department of Neurology, the First Hospital of Jilin University, Changchun 130021, China; Shenzhen Key Laboratory of Biomimetic Materials and Cellular Immunomodulation, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaDepartment of Neurology, the First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Neurology, the First Hospital of Jilin University, Changchun 130021, ChinaShenzhen Key Laboratory of Biomimetic Materials and Cellular Immunomodulation, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; Corresponding authorThe blood-brain barrier (BBB) prevents unregulated substance exchange between the central nervous system and the blood, while providing highly regulated transport of nutrients and tonic factors essential to brain metabolism. A group of carriers, transporters, and receptors is utilized by endothelial cells of the BBB to aid the influx and efflux of nutrients and metabolic wastes, and their function is subject to changes during metabolic disorders such as diabetes mellitus and obesity. This regulated barrier function of BBB is essential for maintaining the normal metabolism of the brain and transduction of metabolic signals from the periphery. As such, disruption of the BBB nutrient/hormone transport system has been proposed to be major contributors of many neurological diseases.http://www.sciencedirect.com/science/article/pii/S2707368823000614Blood-brain barrierMetabolic disordersDiabetes mellitusObesity |
| spellingShingle | Dianhui ZHANG Zhenni GUO Yi YANG Junlei CHANG Regulation of brain metabolism by peripheral nutritional signals: the role of blood-brain barrier in health and disease Journal of Holistic Integrative Pharmacy Blood-brain barrier Metabolic disorders Diabetes mellitus Obesity |
| title | Regulation of brain metabolism by peripheral nutritional signals: the role of blood-brain barrier in health and disease |
| title_full | Regulation of brain metabolism by peripheral nutritional signals: the role of blood-brain barrier in health and disease |
| title_fullStr | Regulation of brain metabolism by peripheral nutritional signals: the role of blood-brain barrier in health and disease |
| title_full_unstemmed | Regulation of brain metabolism by peripheral nutritional signals: the role of blood-brain barrier in health and disease |
| title_short | Regulation of brain metabolism by peripheral nutritional signals: the role of blood-brain barrier in health and disease |
| title_sort | regulation of brain metabolism by peripheral nutritional signals the role of blood brain barrier in health and disease |
| topic | Blood-brain barrier Metabolic disorders Diabetes mellitus Obesity |
| url | http://www.sciencedirect.com/science/article/pii/S2707368823000614 |
| work_keys_str_mv | AT dianhuizhang regulationofbrainmetabolismbyperipheralnutritionalsignalstheroleofbloodbrainbarrierinhealthanddisease AT zhenniguo regulationofbrainmetabolismbyperipheralnutritionalsignalstheroleofbloodbrainbarrierinhealthanddisease AT yiyang regulationofbrainmetabolismbyperipheralnutritionalsignalstheroleofbloodbrainbarrierinhealthanddisease AT junleichang regulationofbrainmetabolismbyperipheralnutritionalsignalstheroleofbloodbrainbarrierinhealthanddisease |