Immature morphology of adult-born granule cells alters responsiveness and excitability in a multi-compartmental conductance-based model
The dentate gyrus of the hippocampus is emerging as a focal target in pattern separation and completion in recent years. Adult neurogenesis in the subgranular zone further provides a unique developmental advantage to this region by supporting the regional activity of newborn granule cells, when requ...
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| Format: | Article |
| Language: | English |
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Tunç ÇATAL
2025-07-01
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| Series: | The European Chemistry and Biotechnology Journal |
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| Online Access: | https://euchembioj.com/index.php/pub/article/view/57 |
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| author | Bahar Sert Pinar Oz |
| author_facet | Bahar Sert Pinar Oz |
| author_sort | Bahar Sert |
| collection | DOAJ |
| description | The dentate gyrus of the hippocampus is emerging as a focal target in pattern separation and completion in recent years. Adult neurogenesis in the subgranular zone further provides a unique developmental advantage to this region by supporting the regional activity of newborn granule cells, when required. The contribution of adult-born granule cells (AdB GCs) to the local circuits can be attributed to their differences from embryonic-born mature GCs in terms of their morphological and biophysical characteristics. AdB GCs are highly excitable cells that show sparse activity. In this study, our focus was on how the morphological distinction of early AdB GCs from mature GCs affects their responsiveness. The reduced multi-compartmental conductance-based models are designed on Python environment with Brian2 module with simple Hodgkin-Huxley type Na and K conductances. Our results indicate that the early morphology of AdB GCs is optimized for faster action potential kinetics and higher excitability compared to mature GCs, even without any biophysical differences. |
| format | Article |
| id | doaj-art-a3270b13693d4463a55a78b33dff2a28 |
| institution | DOAJ |
| issn | 3023-5839 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Tunç ÇATAL |
| record_format | Article |
| series | The European Chemistry and Biotechnology Journal |
| spelling | doaj-art-a3270b13693d4463a55a78b33dff2a282025-08-20T03:13:44ZengTunç ÇATALThe European Chemistry and Biotechnology Journal3023-58392025-07-014536810.62063/ecb-5757Immature morphology of adult-born granule cells alters responsiveness and excitability in a multi-compartmental conductance-based modelBahar Sert0https://orcid.org/0009-0003-3806-9791Pinar Oz1https://orcid.org/0000-0001-6006-9921Üsküdar University Üsküdar UniversityThe dentate gyrus of the hippocampus is emerging as a focal target in pattern separation and completion in recent years. Adult neurogenesis in the subgranular zone further provides a unique developmental advantage to this region by supporting the regional activity of newborn granule cells, when required. The contribution of adult-born granule cells (AdB GCs) to the local circuits can be attributed to their differences from embryonic-born mature GCs in terms of their morphological and biophysical characteristics. AdB GCs are highly excitable cells that show sparse activity. In this study, our focus was on how the morphological distinction of early AdB GCs from mature GCs affects their responsiveness. The reduced multi-compartmental conductance-based models are designed on Python environment with Brian2 module with simple Hodgkin-Huxley type Na and K conductances. Our results indicate that the early morphology of AdB GCs is optimized for faster action potential kinetics and higher excitability compared to mature GCs, even without any biophysical differences.https://euchembioj.com/index.php/pub/article/view/57adult-born granule cellsmature granule cellscomputational models of granule cellsmorphologyneural dynamics |
| spellingShingle | Bahar Sert Pinar Oz Immature morphology of adult-born granule cells alters responsiveness and excitability in a multi-compartmental conductance-based model The European Chemistry and Biotechnology Journal adult-born granule cells mature granule cells computational models of granule cells morphology neural dynamics |
| title | Immature morphology of adult-born granule cells alters responsiveness and excitability in a multi-compartmental conductance-based model |
| title_full | Immature morphology of adult-born granule cells alters responsiveness and excitability in a multi-compartmental conductance-based model |
| title_fullStr | Immature morphology of adult-born granule cells alters responsiveness and excitability in a multi-compartmental conductance-based model |
| title_full_unstemmed | Immature morphology of adult-born granule cells alters responsiveness and excitability in a multi-compartmental conductance-based model |
| title_short | Immature morphology of adult-born granule cells alters responsiveness and excitability in a multi-compartmental conductance-based model |
| title_sort | immature morphology of adult born granule cells alters responsiveness and excitability in a multi compartmental conductance based model |
| topic | adult-born granule cells mature granule cells computational models of granule cells morphology neural dynamics |
| url | https://euchembioj.com/index.php/pub/article/view/57 |
| work_keys_str_mv | AT baharsert immaturemorphologyofadultborngranulecellsaltersresponsivenessandexcitabilityinamulticompartmentalconductancebasedmodel AT pinaroz immaturemorphologyofadultborngranulecellsaltersresponsivenessandexcitabilityinamulticompartmentalconductancebasedmodel |